A study of the subdiffusion of small molecules in charged polyelectrolyte multilayers

Abstract A theoretical approach has been developed here to describe the slow diffusion of small charged molecules of sodium dithionite (S2O4 2−) in polyelectrolyte multilayers (PEMs) composed of polyallylamine hydrochloride (PAH) and polystyrene sulfonate (PSS), which is demonstrated here to be a ca...

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Autores principales:	I. Vardanyan, V. Arakelyan, Z. Navoyan, Eleftheria Diamanti, S. E. Moya, E. Donath
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7b0f1434b7c14557b8bf52832fccab3a
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spelling	oai:doaj.org-article:7b0f1434b7c14557b8bf52832fccab3a2021-11-21T12:18:29ZA study of the subdiffusion of small molecules in charged polyelectrolyte multilayers10.1038/s41598-021-01935-72045-2322https://doaj.org/article/7b0f1434b7c14557b8bf52832fccab3a2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01935-7https://doaj.org/toc/2045-2322Abstract A theoretical approach has been developed here to describe the slow diffusion of small charged molecules of sodium dithionite (S2O4 2−) in polyelectrolyte multilayers (PEMs) composed of polyallylamine hydrochloride (PAH) and polystyrene sulfonate (PSS), which is demonstrated here to be a case of subdifussion. Diffusion is measured experimentally by recording the quenching of the fluorescence of (7-nitrobenz-2-oxa-1,3-diazol-4yl) amino (NBD) labelled PAH layers assembled on silica particles by flow cytometry. NBD is reduced when it encounters dithionite leading to the disappearance of the fluorescence. The fluorescence decay curves show a slow diffusion of dithionite, that does not follow classical Fickean law. Dithionite diffusion in the PEMs is shown to be a non-Markovian process and the slow diffusion can be described via diffusion equations with fractional time derivatives. Results are explained assuming subdifussion of dithionite in the PEMs, as a result of the trapping of the negatively charged dithionite in the positively charged layers of PAH.I. VardanyanV. ArakelyanZ. NavoyanEleftheria DiamantiS. E. MoyaE. DonathNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q I. Vardanyan V. Arakelyan Z. Navoyan Eleftheria Diamanti S. E. Moya E. Donath A study of the subdiffusion of small molecules in charged polyelectrolyte multilayers
description	Abstract A theoretical approach has been developed here to describe the slow diffusion of small charged molecules of sodium dithionite (S2O4 2−) in polyelectrolyte multilayers (PEMs) composed of polyallylamine hydrochloride (PAH) and polystyrene sulfonate (PSS), which is demonstrated here to be a case of subdifussion. Diffusion is measured experimentally by recording the quenching of the fluorescence of (7-nitrobenz-2-oxa-1,3-diazol-4yl) amino (NBD) labelled PAH layers assembled on silica particles by flow cytometry. NBD is reduced when it encounters dithionite leading to the disappearance of the fluorescence. The fluorescence decay curves show a slow diffusion of dithionite, that does not follow classical Fickean law. Dithionite diffusion in the PEMs is shown to be a non-Markovian process and the slow diffusion can be described via diffusion equations with fractional time derivatives. Results are explained assuming subdifussion of dithionite in the PEMs, as a result of the trapping of the negatively charged dithionite in the positively charged layers of PAH.
format	article
author	I. Vardanyan V. Arakelyan Z. Navoyan Eleftheria Diamanti S. E. Moya E. Donath
author_facet	I. Vardanyan V. Arakelyan Z. Navoyan Eleftheria Diamanti S. E. Moya E. Donath
author_sort	I. Vardanyan
title	A study of the subdiffusion of small molecules in charged polyelectrolyte multilayers
title_short	A study of the subdiffusion of small molecules in charged polyelectrolyte multilayers
title_full	A study of the subdiffusion of small molecules in charged polyelectrolyte multilayers
title_fullStr	A study of the subdiffusion of small molecules in charged polyelectrolyte multilayers
title_full_unstemmed	A study of the subdiffusion of small molecules in charged polyelectrolyte multilayers
title_sort	study of the subdiffusion of small molecules in charged polyelectrolyte multilayers
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7b0f1434b7c14557b8bf52832fccab3a
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A study of the subdiffusion of small molecules in charged polyelectrolyte multilayers

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