Autophagy: The Potential Link between SARS-CoV-2 and Cancer

COVID-19 infection survivors suffer from a constellation of symptoms referred to as post-acute COVID-19 syndrome. However, in the wake of recent evidence highlighting the long-term persistence of SARS-CoV-2 antigens in tissues and emerging information regarding the interaction between SARS-CoV-2 pro...

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Autores principales:	Parham Habibzadeh, Hassan Dastsooz, Mehdi Eshraghi, Marek J. Łos, Daniel J. Klionsky, Saeid Ghavami
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	colorectal neoplasms COVID-19 gastrointestinal neoplasms immune checkpoint inhibitors neoplasms oncogenic viruses Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/7b11b29596f34f41a7e1c23b2068f522
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spelling	oai:doaj.org-article:7b11b29596f34f41a7e1c23b2068f5222021-11-25T17:03:15ZAutophagy: The Potential Link between SARS-CoV-2 and Cancer10.3390/cancers132257212072-6694https://doaj.org/article/7b11b29596f34f41a7e1c23b2068f5222021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5721https://doaj.org/toc/2072-6694COVID-19 infection survivors suffer from a constellation of symptoms referred to as post-acute COVID-19 syndrome. However, in the wake of recent evidence highlighting the long-term persistence of SARS-CoV-2 antigens in tissues and emerging information regarding the interaction between SARS-CoV-2 proteins and various components of the host cell macroautophagy/autophagy machinery, the unforeseen long-term consequences of this infection, such as increased risk of malignancies, should be explored. Although SARS-CoV-2 is not considered an oncogenic virus, the possibility of increased risk of cancer among COVID-19 survivors cannot be ruled out. Herein, we provide an overview of the possible mechanisms leading to cancer development, particularly obesity-related cancers (e.g., colorectal cancer), resulting from defects in autophagy and the blockade of the autophagic flux, and also immune escape in COVID-19 survivors. We also highlight the potential long-term implications of COVID-19 infection in the prognosis of patients with cancer and their response to different cancer treatments. Finally, we consider future directions for further investigations on this matter.Parham HabibzadehHassan DastsoozMehdi EshraghiMarek J. ŁosDaniel J. KlionskySaeid GhavamiMDPI AGarticlecolorectal neoplasmsCOVID-19gastrointestinal neoplasmsimmune checkpoint inhibitorsneoplasmsoncogenic virusesNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5721, p 5721 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	colorectal neoplasms COVID-19 gastrointestinal neoplasms immune checkpoint inhibitors neoplasms oncogenic viruses Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	colorectal neoplasms COVID-19 gastrointestinal neoplasms immune checkpoint inhibitors neoplasms oncogenic viruses Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Parham Habibzadeh Hassan Dastsooz Mehdi Eshraghi Marek J. Łos Daniel J. Klionsky Saeid Ghavami Autophagy: The Potential Link between SARS-CoV-2 and Cancer
description	COVID-19 infection survivors suffer from a constellation of symptoms referred to as post-acute COVID-19 syndrome. However, in the wake of recent evidence highlighting the long-term persistence of SARS-CoV-2 antigens in tissues and emerging information regarding the interaction between SARS-CoV-2 proteins and various components of the host cell macroautophagy/autophagy machinery, the unforeseen long-term consequences of this infection, such as increased risk of malignancies, should be explored. Although SARS-CoV-2 is not considered an oncogenic virus, the possibility of increased risk of cancer among COVID-19 survivors cannot be ruled out. Herein, we provide an overview of the possible mechanisms leading to cancer development, particularly obesity-related cancers (e.g., colorectal cancer), resulting from defects in autophagy and the blockade of the autophagic flux, and also immune escape in COVID-19 survivors. We also highlight the potential long-term implications of COVID-19 infection in the prognosis of patients with cancer and their response to different cancer treatments. Finally, we consider future directions for further investigations on this matter.
format	article
author	Parham Habibzadeh Hassan Dastsooz Mehdi Eshraghi Marek J. Łos Daniel J. Klionsky Saeid Ghavami
author_facet	Parham Habibzadeh Hassan Dastsooz Mehdi Eshraghi Marek J. Łos Daniel J. Klionsky Saeid Ghavami
author_sort	Parham Habibzadeh
title	Autophagy: The Potential Link between SARS-CoV-2 and Cancer
title_short	Autophagy: The Potential Link between SARS-CoV-2 and Cancer
title_full	Autophagy: The Potential Link between SARS-CoV-2 and Cancer
title_fullStr	Autophagy: The Potential Link between SARS-CoV-2 and Cancer
title_full_unstemmed	Autophagy: The Potential Link between SARS-CoV-2 and Cancer
title_sort	autophagy: the potential link between sars-cov-2 and cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7b11b29596f34f41a7e1c23b2068f522
work_keys_str_mv	AT parhamhabibzadeh autophagythepotentiallinkbetweensarscov2andcancer AT hassandastsooz autophagythepotentiallinkbetweensarscov2andcancer AT mehdieshraghi autophagythepotentiallinkbetweensarscov2andcancer AT marekjłos autophagythepotentiallinkbetweensarscov2andcancer AT danieljklionsky autophagythepotentiallinkbetweensarscov2andcancer AT saeidghavami autophagythepotentiallinkbetweensarscov2andcancer
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Autophagy: The Potential Link between SARS-CoV-2 and Cancer

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