Effect of programmed cell death factor 4 on the severity of coronary heart disease and coronary artery disease with blood stasis and toxin
Objective: To explore the diagnostic value of PDCD4 on the degree of arterial stenosis in "blood stasis" coronary heart disease. Methods: Select 80 patients with coronary heart disease in the Second Cardiovascular Zone of the First Affiliated Hospital of Guangxi University of Traditiona...
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| Formato: | article |
| Lenguaje: | EN |
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Editorial Board of Journal of Hainan Medical University
2021
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| Acceso en línea: | https://doaj.org/article/7b1424cabf3a4ad9b59da4eaddb7449a |
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| Sumario: | Objective: To explore the diagnostic value of PDCD4 on the degree of arterial stenosis in
"blood stasis" coronary heart disease. Methods: Select 80 patients with coronary heart disease
in the Second Cardiovascular Zone of the First Affiliated Hospital of Guangxi University of
Traditional Chinese Medicine in April 2020, and divide them into the "phlegm toxin" group
(n=40) and the "phlegm stasis" group (n=40) based on the dialectics of traditional Chinese
medicine. ). Record the gender, age, smoking, and alcohol consumption of the subjects between
the two groups, and detect their white blood cell count, neutrophil count, platelet count,
platelet volume, platelet distribution width, blood creatinine, uric acid, cystatin, and fibrin The
expression levels of original, high-sensitivity C-reactive protein, D-dimer, total cholesterol,
triglycerides, high-density lipoprotein, low-density lipoprotein, apolipoprotein a, apolipoprotein
b, and PDCD4. Multivariate logistic regression analysis was used to screen out the risk
factors that affect coronary plaque formation, and the receiver operating characteristic (ROC)
curve of each index was established to evaluate the severity of coronary stenosis in patients
with stasis coronary heart disease by each index and combined index Diagnostic efficiency.
Results: The two groups of patients were tested in terms of gender, age, smoking, drinking,
triglycerides, cholesterol, high-density lipoprotein, low-density lipoprotein, apolipoprotein-a,
apolipoprotein-b, white blood cell count, neutrophil The cell count, platelet count, platelet
volume width and platelet distribution width were not statistically significant (P>0.05); the
expression levels of hypersensitivity-C-reactive protein, serum creatinine, cystatin, uric acid
and PDCD4 were statistically significant between the two groups Difference (P<0.05), and the
corresponding hypersensitivity-C-reactive protein, creatinine, cystatin, uric acid and PDCD4
expression levels in the blood stasis group were higher than those in the phlegm blood stasis
group. After multivariate logistic regression analysis, the level of PDCD4 in peripheral blood
[OR=31.088, 95%CI (2.498, 3.869)] was an independent influencing factor of the "stagnation"
type of coronary heart disease, and PDCD4 was diagnosed as the "stagnation" type of coronary
heart disease The area under the ROC curve (AUC) is 88.6%, 95%CI (1.894, 2.532) (P=0.29);
the level of PDCD4 in peripheral blood is positively correlated with the number and severity
of coronary artery disease, the number of coronary artery disease and stenosis The greater
the degree, the higher the detection value of PDCD4, (P<0.05). Conclusion: The expression
level of PDCD4 in peripheral blood is closely related to the subtype of "stasis toxin" and the
severity of coronary vascular stenosis. It can be used as a quantitative diagnostic index for the
diagnosis of "stasis toxin" coronary heart disease and the severity of coronary vascular stenosis.
Keywords: programmed death factor 4; stasis toxin; coronary heart disease; atherosclerosis |
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