Widespread reorganisation of pluripotent factor binding and gene regulatory interactions between human pluripotent states

The role of transcriptional enhancers and 3D chromatin organisation in coordinating the transition from naive to primed pluripotency remains poorly understood. Here the authors generate a high-resolution atlas of gene regulatory interactions, chromatin profiles and transcription factor occupancy in...

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Autores principales:	Peter Chovanec, Amanda J. Collier, Christel Krueger, Csilla Várnai, Claudia I. Semprich, Stefan Schoenfelder, Anne E. Corcoran, Peter J. Rugg-Gunn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7b14988f9bbd452bb5b113c07a446d36
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spelling	oai:doaj.org-article:7b14988f9bbd452bb5b113c07a446d362021-12-02T18:15:30ZWidespread reorganisation of pluripotent factor binding and gene regulatory interactions between human pluripotent states10.1038/s41467-021-22201-42041-1723https://doaj.org/article/7b14988f9bbd452bb5b113c07a446d362021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22201-4https://doaj.org/toc/2041-1723The role of transcriptional enhancers and 3D chromatin organisation in coordinating the transition from naive to primed pluripotency remains poorly understood. Here the authors generate a high-resolution atlas of gene regulatory interactions, chromatin profiles and transcription factor occupancy in naive and primed human pluripotent stem cells to provide insights into these developmental processes.Peter ChovanecAmanda J. CollierChristel KruegerCsilla VárnaiClaudia I. SemprichStefan SchoenfelderAnne E. CorcoranPeter J. Rugg-GunnNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Peter Chovanec Amanda J. Collier Christel Krueger Csilla Várnai Claudia I. Semprich Stefan Schoenfelder Anne E. Corcoran Peter J. Rugg-Gunn Widespread reorganisation of pluripotent factor binding and gene regulatory interactions between human pluripotent states
description	The role of transcriptional enhancers and 3D chromatin organisation in coordinating the transition from naive to primed pluripotency remains poorly understood. Here the authors generate a high-resolution atlas of gene regulatory interactions, chromatin profiles and transcription factor occupancy in naive and primed human pluripotent stem cells to provide insights into these developmental processes.
format	article
author	Peter Chovanec Amanda J. Collier Christel Krueger Csilla Várnai Claudia I. Semprich Stefan Schoenfelder Anne E. Corcoran Peter J. Rugg-Gunn
author_facet	Peter Chovanec Amanda J. Collier Christel Krueger Csilla Várnai Claudia I. Semprich Stefan Schoenfelder Anne E. Corcoran Peter J. Rugg-Gunn
author_sort	Peter Chovanec
title	Widespread reorganisation of pluripotent factor binding and gene regulatory interactions between human pluripotent states
title_short	Widespread reorganisation of pluripotent factor binding and gene regulatory interactions between human pluripotent states
title_full	Widespread reorganisation of pluripotent factor binding and gene regulatory interactions between human pluripotent states
title_fullStr	Widespread reorganisation of pluripotent factor binding and gene regulatory interactions between human pluripotent states
title_full_unstemmed	Widespread reorganisation of pluripotent factor binding and gene regulatory interactions between human pluripotent states
title_sort	widespread reorganisation of pluripotent factor binding and gene regulatory interactions between human pluripotent states
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7b14988f9bbd452bb5b113c07a446d36
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Widespread reorganisation of pluripotent factor binding and gene regulatory interactions between human pluripotent states

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