Biomedical Potential of Plant-Based Selenium Nanoparticles: A Comprehensive Review on Therapeutic and Mechanistic Aspects

Muhammad Ikram,* Bilal Javed,* Naveed Iqbal Raja, Zia-ur-Rehman Mashwani Department of Botany, PMAS Arid Agriculture University, Rawalpindi, Punjab 46300, Pakistan*These authors contributed equally to this workCorrespondence: Bilal Javed Email javedbilal87@gmail.comMuhammad Ikram Email ikramgondal46...

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Autores principales:	Ikram M, Javed B, Raja NI, Mashwani ZUR
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	green synthesis senps drug delivery diabetes cancer reactive oxygen species. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7b16297aabcf48fdabdc44dbf4e6b605
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spelling	oai:doaj.org-article:7b16297aabcf48fdabdc44dbf4e6b6052021-12-02T16:00:27ZBiomedical Potential of Plant-Based Selenium Nanoparticles: A Comprehensive Review on Therapeutic and Mechanistic Aspects1178-2013https://doaj.org/article/7b16297aabcf48fdabdc44dbf4e6b6052021-01-01T00:00:00Zhttps://www.dovepress.com/biomedical-potential-of-plant-based-selenium-nanoparticles-a-comprehen-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Muhammad Ikram,* Bilal Javed,* Naveed Iqbal Raja, Zia-ur-Rehman Mashwani Department of Botany, PMAS Arid Agriculture University, Rawalpindi, Punjab 46300, Pakistan*These authors contributed equally to this workCorrespondence: Bilal Javed Email javedbilal87@gmail.comMuhammad Ikram Email ikramgondal464@gmail.comAbstract: Selenium nanoparticles (SeNPs) have advantages over other nanomaterials because of the promising role of selenium in the stabilization of the immune system and activation of the defense response. The use of SeNPs and their supplements not only have pharmacological significance but also boost and prepare the body’s immune system to fight the pathogens. This review summarizes the recent progress in the biogenesis of plant-based SeNPs by using various plant species and the role of secondary metabolites on their biocompatible functioning. Phyto-synthesis of SeNPs results in the synthesis of nanomaterials of various, size, shape and biochemical nature and has advantages over other routine physical and chemical methods because of their biocompatibility, eco-friendly nature and in vivo actions. Unfortunately, the plant-based SeNPs failed to attain considerable attention in the pharmaceutical industry. However, a few studies were performed to explore the therapeutic potential of the SeNPs against various cancer cells, microbial pathogens, viral infections, hepatoprotective actions, diabetic management, and antioxidant approaches. Further, some of the selenium-based drug delivery systems are developed by engineering the SeNPs with the functional ligands to deliver drugs to the targeted sites. This review also provides up-to-date information on the mechanistic actions that the SeNPs adopt to achieve their designated tasks as it may help to develop precision medicine with customized treatment and healthcare for the ailing population.Keywords: green synthesis, SeNPs, drug delivery, diabetes, cancer, reactive oxygen speciesIkram MJaved BRaja NIMashwani ZURDove Medical Pressarticlegreen synthesissenpsdrug deliverydiabetescancerreactive oxygen species.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 249-268 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	green synthesis senps drug delivery diabetes cancer reactive oxygen species. Medicine (General) R5-920
spellingShingle	green synthesis senps drug delivery diabetes cancer reactive oxygen species. Medicine (General) R5-920 Ikram M Javed B Raja NI Mashwani ZUR Biomedical Potential of Plant-Based Selenium Nanoparticles: A Comprehensive Review on Therapeutic and Mechanistic Aspects
description	Muhammad Ikram,* Bilal Javed,* Naveed Iqbal Raja, Zia-ur-Rehman Mashwani Department of Botany, PMAS Arid Agriculture University, Rawalpindi, Punjab 46300, Pakistan*These authors contributed equally to this workCorrespondence: Bilal Javed Email javedbilal87@gmail.comMuhammad Ikram Email ikramgondal464@gmail.comAbstract: Selenium nanoparticles (SeNPs) have advantages over other nanomaterials because of the promising role of selenium in the stabilization of the immune system and activation of the defense response. The use of SeNPs and their supplements not only have pharmacological significance but also boost and prepare the body’s immune system to fight the pathogens. This review summarizes the recent progress in the biogenesis of plant-based SeNPs by using various plant species and the role of secondary metabolites on their biocompatible functioning. Phyto-synthesis of SeNPs results in the synthesis of nanomaterials of various, size, shape and biochemical nature and has advantages over other routine physical and chemical methods because of their biocompatibility, eco-friendly nature and in vivo actions. Unfortunately, the plant-based SeNPs failed to attain considerable attention in the pharmaceutical industry. However, a few studies were performed to explore the therapeutic potential of the SeNPs against various cancer cells, microbial pathogens, viral infections, hepatoprotective actions, diabetic management, and antioxidant approaches. Further, some of the selenium-based drug delivery systems are developed by engineering the SeNPs with the functional ligands to deliver drugs to the targeted sites. This review also provides up-to-date information on the mechanistic actions that the SeNPs adopt to achieve their designated tasks as it may help to develop precision medicine with customized treatment and healthcare for the ailing population.Keywords: green synthesis, SeNPs, drug delivery, diabetes, cancer, reactive oxygen species
format	article
author	Ikram M Javed B Raja NI Mashwani ZUR
author_facet	Ikram M Javed B Raja NI Mashwani ZUR
author_sort	Ikram M
title	Biomedical Potential of Plant-Based Selenium Nanoparticles: A Comprehensive Review on Therapeutic and Mechanistic Aspects
title_short	Biomedical Potential of Plant-Based Selenium Nanoparticles: A Comprehensive Review on Therapeutic and Mechanistic Aspects
title_full	Biomedical Potential of Plant-Based Selenium Nanoparticles: A Comprehensive Review on Therapeutic and Mechanistic Aspects
title_fullStr	Biomedical Potential of Plant-Based Selenium Nanoparticles: A Comprehensive Review on Therapeutic and Mechanistic Aspects
title_full_unstemmed	Biomedical Potential of Plant-Based Selenium Nanoparticles: A Comprehensive Review on Therapeutic and Mechanistic Aspects
title_sort	biomedical potential of plant-based selenium nanoparticles: a comprehensive review on therapeutic and mechanistic aspects
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/7b16297aabcf48fdabdc44dbf4e6b605
work_keys_str_mv	AT ikramm biomedicalpotentialofplantbasedseleniumnanoparticlesacomprehensivereviewontherapeuticandmechanisticaspects AT javedb biomedicalpotentialofplantbasedseleniumnanoparticlesacomprehensivereviewontherapeuticandmechanisticaspects AT rajani biomedicalpotentialofplantbasedseleniumnanoparticlesacomprehensivereviewontherapeuticandmechanisticaspects AT mashwanizur biomedicalpotentialofplantbasedseleniumnanoparticlesacomprehensivereviewontherapeuticandmechanisticaspects
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Biomedical Potential of Plant-Based Selenium Nanoparticles: A Comprehensive Review on Therapeutic and Mechanistic Aspects

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