Location and temporal memory of objects declines in aged marmosets (Callithrix jacchus)

Abstract Episodic memory decline is an early marker of cognitive aging in human. Although controversial in animals and called “episodic-like memory”, several models have been successfully developed, however they rarely focused on ageing. While marmoset is an emerging primate model in aging science,...

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Autores principales:	Vanessa De Castro, Pascal Girard
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7b1e708563cd4b83801fd5ab718e48be
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spelling	oai:doaj.org-article:7b1e708563cd4b83801fd5ab718e48be2021-12-02T17:14:58ZLocation and temporal memory of objects declines in aged marmosets (Callithrix jacchus)10.1038/s41598-021-88357-72045-2322https://doaj.org/article/7b1e708563cd4b83801fd5ab718e48be2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88357-7https://doaj.org/toc/2045-2322Abstract Episodic memory decline is an early marker of cognitive aging in human. Although controversial in animals and called “episodic-like memory”, several models have been successfully developed, however they rarely focused on ageing. While marmoset is an emerging primate model in aging science, episodic-like memory has never been tested in this species and importantly in aged marmosets. Here, we examined if the recall of the what-when and what-where building blocks of episodic-like memory declines in ageing marmosets. We developed a naturalistic approach using spontaneous exploration of real objects by young and old marmosets in the home cage. We implemented a three-trial task with 1 week inter-trial interval. Two different sets of identical objects were presented in sample trials 1 and 2, respectively. For the test trial, two objects from each set were presented in a former position and two in a new one. We quantified the exploratory behaviour and calculated discrimination indices in a cohort of 20 marmosets. Young animals presented a preserved memory for combined what-where, and what-when components of the experiment, which declined with aging. These findings lead one to expect episodic-like memory deficits in aged marmosets.Vanessa De CastroPascal GirardNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vanessa De Castro Pascal Girard Location and temporal memory of objects declines in aged marmosets (Callithrix jacchus)
description	Abstract Episodic memory decline is an early marker of cognitive aging in human. Although controversial in animals and called “episodic-like memory”, several models have been successfully developed, however they rarely focused on ageing. While marmoset is an emerging primate model in aging science, episodic-like memory has never been tested in this species and importantly in aged marmosets. Here, we examined if the recall of the what-when and what-where building blocks of episodic-like memory declines in ageing marmosets. We developed a naturalistic approach using spontaneous exploration of real objects by young and old marmosets in the home cage. We implemented a three-trial task with 1 week inter-trial interval. Two different sets of identical objects were presented in sample trials 1 and 2, respectively. For the test trial, two objects from each set were presented in a former position and two in a new one. We quantified the exploratory behaviour and calculated discrimination indices in a cohort of 20 marmosets. Young animals presented a preserved memory for combined what-where, and what-when components of the experiment, which declined with aging. These findings lead one to expect episodic-like memory deficits in aged marmosets.
format	article
author	Vanessa De Castro Pascal Girard
author_facet	Vanessa De Castro Pascal Girard
author_sort	Vanessa De Castro
title	Location and temporal memory of objects declines in aged marmosets (Callithrix jacchus)
title_short	Location and temporal memory of objects declines in aged marmosets (Callithrix jacchus)
title_full	Location and temporal memory of objects declines in aged marmosets (Callithrix jacchus)
title_fullStr	Location and temporal memory of objects declines in aged marmosets (Callithrix jacchus)
title_full_unstemmed	Location and temporal memory of objects declines in aged marmosets (Callithrix jacchus)
title_sort	location and temporal memory of objects declines in aged marmosets (callithrix jacchus)
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7b1e708563cd4b83801fd5ab718e48be
work_keys_str_mv	AT vanessadecastro locationandtemporalmemoryofobjectsdeclinesinagedmarmosetscallithrixjacchus AT pascalgirard locationandtemporalmemoryofobjectsdeclinesinagedmarmosetscallithrixjacchus
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Location and temporal memory of objects declines in aged marmosets (Callithrix jacchus)

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