Psoriasis: epidemiology, natural history, and differential diagnosis

Juliana L Basko-Plluska, Vesna Petronic-RosicDepartment of Medicine, Section of Dermatology, University of Chicago, Chicago, IL, USAAbstract: Psoriasis is a chronic, immune-mediated, inflammatory disease which affects primarily the skin and joints. It occurs worldwide, but its prevalence varies cons...

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Autores principales:	Basko-Plluska JL, Petronic-Rosic V
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/7b2197c5b5054387b3d5d29fbdeacd96
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spelling	oai:doaj.org-article:7b2197c5b5054387b3d5d29fbdeacd962021-12-02T00:22:42ZPsoriasis: epidemiology, natural history, and differential diagnosis2230-326Xhttps://doaj.org/article/7b2197c5b5054387b3d5d29fbdeacd962012-09-01T00:00:00Zhttp://www.dovepress.com/psoriasis-epidemiology-natural-history-and-differential-diagnosis-a10969https://doaj.org/toc/2230-326XJuliana L Basko-Plluska, Vesna Petronic-RosicDepartment of Medicine, Section of Dermatology, University of Chicago, Chicago, IL, USAAbstract: Psoriasis is a chronic, immune-mediated, inflammatory disease which affects primarily the skin and joints. It occurs worldwide, but its prevalence varies considerably between different regions of the world. Genetic susceptibility as well as environmental factors play an important role in determining the development and prognosis of psoriasis. Genome-wide association studies have identified many genetic loci as potential psoriasis susceptibility regions, including PSORS1 through PSORS7. Histocompatibility antigen (HLA) studies have also identified several HLA antigens, with HLA-Cw6 being the most frequently associated antigen. Epidemiological studies identified several modifiable risk factors that may predispose individuals to developing psoriasis or exacerbate pre-existing disease. These include smoking, obesity, alcohol consumption, diet, infections, medications and stressful life events. The exact mechanism by which they trigger psoriasis remains to be elucidated; however, existing data suggest that they are linked through Th1-mediated immunological pathways. The natural history of psoriasis varies depending on the clinical subtype as well as special circumstances, including pregnancy and HIV infection. In general, psoriasis is a chronic disease with intermittent remissions and exacerbations. The differential diagnosis is vast and includes many other immune-mediated, inflammatory disorders.Keywords: psoriasis, epidemiology, natural history, differential diagnosisBasko-Plluska JLPetronic-Rosic VDove Medical PressarticleDermatologyRL1-803ENPsoriasis: Targets and Therapy, Vol 2012, Iss default, Pp 67-76 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Dermatology RL1-803
spellingShingle	Dermatology RL1-803 Basko-Plluska JL Petronic-Rosic V Psoriasis: epidemiology, natural history, and differential diagnosis
description	Juliana L Basko-Plluska, Vesna Petronic-RosicDepartment of Medicine, Section of Dermatology, University of Chicago, Chicago, IL, USAAbstract: Psoriasis is a chronic, immune-mediated, inflammatory disease which affects primarily the skin and joints. It occurs worldwide, but its prevalence varies considerably between different regions of the world. Genetic susceptibility as well as environmental factors play an important role in determining the development and prognosis of psoriasis. Genome-wide association studies have identified many genetic loci as potential psoriasis susceptibility regions, including PSORS1 through PSORS7. Histocompatibility antigen (HLA) studies have also identified several HLA antigens, with HLA-Cw6 being the most frequently associated antigen. Epidemiological studies identified several modifiable risk factors that may predispose individuals to developing psoriasis or exacerbate pre-existing disease. These include smoking, obesity, alcohol consumption, diet, infections, medications and stressful life events. The exact mechanism by which they trigger psoriasis remains to be elucidated; however, existing data suggest that they are linked through Th1-mediated immunological pathways. The natural history of psoriasis varies depending on the clinical subtype as well as special circumstances, including pregnancy and HIV infection. In general, psoriasis is a chronic disease with intermittent remissions and exacerbations. The differential diagnosis is vast and includes many other immune-mediated, inflammatory disorders.Keywords: psoriasis, epidemiology, natural history, differential diagnosis
format	article
author	Basko-Plluska JL Petronic-Rosic V
author_facet	Basko-Plluska JL Petronic-Rosic V
author_sort	Basko-Plluska JL
title	Psoriasis: epidemiology, natural history, and differential diagnosis
title_short	Psoriasis: epidemiology, natural history, and differential diagnosis
title_full	Psoriasis: epidemiology, natural history, and differential diagnosis
title_fullStr	Psoriasis: epidemiology, natural history, and differential diagnosis
title_full_unstemmed	Psoriasis: epidemiology, natural history, and differential diagnosis
title_sort	psoriasis: epidemiology, natural history, and differential diagnosis
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/7b2197c5b5054387b3d5d29fbdeacd96
work_keys_str_mv	AT baskoplluskajl psoriasisepidemiologynaturalhistoryanddifferentialdiagnosis AT petronicrosicv psoriasisepidemiologynaturalhistoryanddifferentialdiagnosis
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Psoriasis: epidemiology, natural history, and differential diagnosis

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