Multiparametric ultrasound examination for response assessment in breast cancer patients undergoing neoadjuvant therapy

Abstract To investigate the performance of multiparametric ultrasound for the evaluation of treatment response in breast cancer patients undergoing neoadjuvant chemotherapy (NAC). The IRB approved this prospective study. Breast cancer patients who were scheduled to undergo NAC were invited to partic...

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Autores principales:	K. Dobruch-Sobczak, H. Piotrzkowska-Wróblewska, Z. Klimonda, P. Karwat, K. Roszkowska-Purska, P. Clauser, P. A. T. Baltzer, J. Litniewski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7b2405d744f14f7fbc492c1419accfec
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spelling	oai:doaj.org-article:7b2405d744f14f7fbc492c1419accfec2021-12-02T13:57:37ZMultiparametric ultrasound examination for response assessment in breast cancer patients undergoing neoadjuvant therapy10.1038/s41598-021-82141-32045-2322https://doaj.org/article/7b2405d744f14f7fbc492c1419accfec2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82141-3https://doaj.org/toc/2045-2322Abstract To investigate the performance of multiparametric ultrasound for the evaluation of treatment response in breast cancer patients undergoing neoadjuvant chemotherapy (NAC). The IRB approved this prospective study. Breast cancer patients who were scheduled to undergo NAC were invited to participate in this study. Changes in tumour echogenicity, stiffness, maximum diameter, vascularity and integrated backscatter coefficient (IBC) were assessed prior to treatment and 7 days after four consecutive NAC cycles. Residual malignant cell (RMC) measurement at surgery was considered as standard of reference. RMC < 30% was considered a good response and > 70% a poor response. The correlation coefficients of these parameters were compared with RMC from post-operative histology. Linear Discriminant Analysis (LDA), cross-validation and Receiver Operating Characteristic curve (ROC) analysis were performed. Thirty patients (mean age 56.4 year) with 42 lesions were included. There was a significant correlation between RMC and echogenicity and tumour diameter after the 3rd course of NAC and average stiffness after the 2nd course. The correlation coefficient for IBC and echogenicity calculated after the first four doses of NAC were 0.27, 0.35, 0.41 and 0.30, respectively. Multivariate analysis of the echogenicity and stiffness after the third NAC revealed a sensitivity of 82%, specificity of 90%, PPV = 75%, NPV = 93%, accuracy = 88% and AUC of 0.88 for non-responding tumours (RMC > 70%). High tumour stiffness and persistent hypoechogenicity after the third NAC course allowed to accurately predict a group of non-responding tumours. A correlation between echogenicity and IBC was demonstrated as well.K. Dobruch-SobczakH. Piotrzkowska-WróblewskaZ. KlimondaP. KarwatK. Roszkowska-PurskaP. ClauserP. A. T. BaltzerJ. LitniewskiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q K. Dobruch-Sobczak H. Piotrzkowska-Wróblewska Z. Klimonda P. Karwat K. Roszkowska-Purska P. Clauser P. A. T. Baltzer J. Litniewski Multiparametric ultrasound examination for response assessment in breast cancer patients undergoing neoadjuvant therapy
description	Abstract To investigate the performance of multiparametric ultrasound for the evaluation of treatment response in breast cancer patients undergoing neoadjuvant chemotherapy (NAC). The IRB approved this prospective study. Breast cancer patients who were scheduled to undergo NAC were invited to participate in this study. Changes in tumour echogenicity, stiffness, maximum diameter, vascularity and integrated backscatter coefficient (IBC) were assessed prior to treatment and 7 days after four consecutive NAC cycles. Residual malignant cell (RMC) measurement at surgery was considered as standard of reference. RMC < 30% was considered a good response and > 70% a poor response. The correlation coefficients of these parameters were compared with RMC from post-operative histology. Linear Discriminant Analysis (LDA), cross-validation and Receiver Operating Characteristic curve (ROC) analysis were performed. Thirty patients (mean age 56.4 year) with 42 lesions were included. There was a significant correlation between RMC and echogenicity and tumour diameter after the 3rd course of NAC and average stiffness after the 2nd course. The correlation coefficient for IBC and echogenicity calculated after the first four doses of NAC were 0.27, 0.35, 0.41 and 0.30, respectively. Multivariate analysis of the echogenicity and stiffness after the third NAC revealed a sensitivity of 82%, specificity of 90%, PPV = 75%, NPV = 93%, accuracy = 88% and AUC of 0.88 for non-responding tumours (RMC > 70%). High tumour stiffness and persistent hypoechogenicity after the third NAC course allowed to accurately predict a group of non-responding tumours. A correlation between echogenicity and IBC was demonstrated as well.
format	article
author	K. Dobruch-Sobczak H. Piotrzkowska-Wróblewska Z. Klimonda P. Karwat K. Roszkowska-Purska P. Clauser P. A. T. Baltzer J. Litniewski
author_facet	K. Dobruch-Sobczak H. Piotrzkowska-Wróblewska Z. Klimonda P. Karwat K. Roszkowska-Purska P. Clauser P. A. T. Baltzer J. Litniewski
author_sort	K. Dobruch-Sobczak
title	Multiparametric ultrasound examination for response assessment in breast cancer patients undergoing neoadjuvant therapy
title_short	Multiparametric ultrasound examination for response assessment in breast cancer patients undergoing neoadjuvant therapy
title_full	Multiparametric ultrasound examination for response assessment in breast cancer patients undergoing neoadjuvant therapy
title_fullStr	Multiparametric ultrasound examination for response assessment in breast cancer patients undergoing neoadjuvant therapy
title_full_unstemmed	Multiparametric ultrasound examination for response assessment in breast cancer patients undergoing neoadjuvant therapy
title_sort	multiparametric ultrasound examination for response assessment in breast cancer patients undergoing neoadjuvant therapy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7b2405d744f14f7fbc492c1419accfec
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Multiparametric ultrasound examination for response assessment in breast cancer patients undergoing neoadjuvant therapy

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