Prevalence and Associated Factors of Diabetic Retinopathy in a Russian Population. The Ural Eye and Medical Study
Mukharram M Bikbov,1 Timur R Gilmanshin,1 Rinat M Zainullin,1 Gyulli M Kazakbaeva,1 Ildar F Nuriyev,1 Artur F Zaynetdinov,1 Songhomitrra Panda-Jonas,2 Guzel M Bikbova,1 Ellina M Rakhimova,1 Iulia A Rusakova,1 Timur A Khalimov,1 Kamila R Safiullina,1 Albina A Fakhretdinova,1 Azaliia M Tuliakova,1 Ain...
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Dove Medical Press
2021
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oai:doaj.org-article:7b267cab89354295bad4235443e269cb2021-12-02T19:17:36ZPrevalence and Associated Factors of Diabetic Retinopathy in a Russian Population. The Ural Eye and Medical Study1178-7007https://doaj.org/article/7b267cab89354295bad4235443e269cb2021-12-01T00:00:00Zhttps://www.dovepress.com/prevalence-and-associated-factors-of-diabetic-retinopathy-in-a-russian-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Mukharram M Bikbov,1 Timur R Gilmanshin,1 Rinat M Zainullin,1 Gyulli M Kazakbaeva,1 Ildar F Nuriyev,1 Artur F Zaynetdinov,1 Songhomitrra Panda-Jonas,2 Guzel M Bikbova,1 Ellina M Rakhimova,1 Iulia A Rusakova,1 Timur A Khalimov,1 Kamila R Safiullina,1 Albina A Fakhretdinova,1 Azaliia M Tuliakova,1 Ainur V Gizzatov,1 Jost B Jonas3,4 1Ufa Eye Research Institute, Ufa, Bashkortostan, Russia; 2Privatpraxis Prof Jonas und Dr Panda-Jonas, Heidelberg, Germany; 3Department of Ophthalmology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; 4Institute of Molecular and Clinical Ophthalmology Basel, Basel, SwitzerlandCorrespondence: Mukharram M Bikbov; Jost B Jonas Tel +7 347 272-37-75; +49-6221-3929320Email Bikbov.m@gmail.com; Jost.Jonas@medma.uni-Heidelberg.deAim: To assess prevalence and associated factors of diabetic retinopathy (DR) in a Russian population.Methods: Out of 7328 eligible individuals, the population-based cross-sectional Ural Eye and Medical Study included 5899 (80.5%) individuals aged 40+ years, who underwent a detailed medical and ophthalmological examination. Using ocular fundus photographs and optical coherence tomographic images, we assessed prevalence and degree of DR in 5105 participants.Results: DR was present in 99/5105 individuals (1.9%; 95% confidence interval [CI]: 1.6, 2.3). Its prevalence increased from 6/657 (1.0%; 95% CI: 0.2, 1.6) in the age group of 45– 50 years to 24/680 (3.5%; 95% CI: 2.1, 4.9) in the age group of 65– 70 years, and decreased to 3/153 (2.0%; 95% CI: 0.00, 4.2) in the age group of 80+ years. DR prevalence within the 577 (11.4%; 95% CI: 10.5, 12.2) individuals with diabetes was 99/577 (17.2%; 95% CI: 14.1, 20.2). DR was the cause for moderate-to-severe vision impairment (best corrected visual acuity < 6/18 but ≥ 3/60) in four individuals (4/5105; 0.07%). In multivariable analysis, higher DR prevalence was associated with higher serum glucose concentration (odds ratio [OR]: 1.30; 95% CI: 1.20, 141), longer diabetes duration (OR: 1.06; 95% CI: 1.02, 1.09), type of diabetes therapy (nil/diet/oral/insulin) (OR:4.19;95% CI:3.08, 5.70), lower educational level (OR:0.81;95% CI:0.67, 0.98), lower manual dynamometric force (OR: 0.96; 95% CI: 0.94, 0.99), shorter ocular axial length (OR: 0.73; 95% CI: 0.56, 0.96), and higher diastolic blood pressure (OR: 1.04; 95% CI: 1.01, 1.06), or alternatively, higher estimated cerebrospinal fluid pressure (OR: 1.09; 95% CI: 1.01, 1.18).Conclusion: In this urban and rural Russian population aged 40+ years, DR prevalence was relatively low (1.9%; 95% CI: 1.6, 2.3), showed an inverted U-shaped association with age, and in a cross-sectional study design it was associated with shorter axial length and higher estimated cerebrospinal fluid pressure.Keywords: diabetic retinopathy, cerebrospinal fluid pressure, myopia, axial length, blindness, ural eye and medical studyBikbov MMGilmanshin TRZainullin RMKazakbaeva GMNuriyev IFZaynetdinov AFPanda-Jonas SBikbova GMRakhimova EMRusakova IAKhalimov TASafiullina KRFakhretdinova AATuliakova AMGizzatov AVJonas JBDove Medical Pressarticlediabetic retinopathycerebrospinal fluid pressuremyopiaaxial lengthblindnessural eye and medical studySpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 4723-4734 (2021) |
| institution |
DOAJ |
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DOAJ |
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EN |
| topic |
diabetic retinopathy cerebrospinal fluid pressure myopia axial length blindness ural eye and medical study Specialties of internal medicine RC581-951 |
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diabetic retinopathy cerebrospinal fluid pressure myopia axial length blindness ural eye and medical study Specialties of internal medicine RC581-951 Bikbov MM Gilmanshin TR Zainullin RM Kazakbaeva GM Nuriyev IF Zaynetdinov AF Panda-Jonas S Bikbova GM Rakhimova EM Rusakova IA Khalimov TA Safiullina KR Fakhretdinova AA Tuliakova AM Gizzatov AV Jonas JB Prevalence and Associated Factors of Diabetic Retinopathy in a Russian Population. The Ural Eye and Medical Study |
| description |
Mukharram M Bikbov,1 Timur R Gilmanshin,1 Rinat M Zainullin,1 Gyulli M Kazakbaeva,1 Ildar F Nuriyev,1 Artur F Zaynetdinov,1 Songhomitrra Panda-Jonas,2 Guzel M Bikbova,1 Ellina M Rakhimova,1 Iulia A Rusakova,1 Timur A Khalimov,1 Kamila R Safiullina,1 Albina A Fakhretdinova,1 Azaliia M Tuliakova,1 Ainur V Gizzatov,1 Jost B Jonas3,4 1Ufa Eye Research Institute, Ufa, Bashkortostan, Russia; 2Privatpraxis Prof Jonas und Dr Panda-Jonas, Heidelberg, Germany; 3Department of Ophthalmology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; 4Institute of Molecular and Clinical Ophthalmology Basel, Basel, SwitzerlandCorrespondence: Mukharram M Bikbov; Jost B Jonas Tel +7 347 272-37-75; +49-6221-3929320Email Bikbov.m@gmail.com; Jost.Jonas@medma.uni-Heidelberg.deAim: To assess prevalence and associated factors of diabetic retinopathy (DR) in a Russian population.Methods: Out of 7328 eligible individuals, the population-based cross-sectional Ural Eye and Medical Study included 5899 (80.5%) individuals aged 40+ years, who underwent a detailed medical and ophthalmological examination. Using ocular fundus photographs and optical coherence tomographic images, we assessed prevalence and degree of DR in 5105 participants.Results: DR was present in 99/5105 individuals (1.9%; 95% confidence interval [CI]: 1.6, 2.3). Its prevalence increased from 6/657 (1.0%; 95% CI: 0.2, 1.6) in the age group of 45– 50 years to 24/680 (3.5%; 95% CI: 2.1, 4.9) in the age group of 65– 70 years, and decreased to 3/153 (2.0%; 95% CI: 0.00, 4.2) in the age group of 80+ years. DR prevalence within the 577 (11.4%; 95% CI: 10.5, 12.2) individuals with diabetes was 99/577 (17.2%; 95% CI: 14.1, 20.2). DR was the cause for moderate-to-severe vision impairment (best corrected visual acuity < 6/18 but ≥ 3/60) in four individuals (4/5105; 0.07%). In multivariable analysis, higher DR prevalence was associated with higher serum glucose concentration (odds ratio [OR]: 1.30; 95% CI: 1.20, 141), longer diabetes duration (OR: 1.06; 95% CI: 1.02, 1.09), type of diabetes therapy (nil/diet/oral/insulin) (OR:4.19;95% CI:3.08, 5.70), lower educational level (OR:0.81;95% CI:0.67, 0.98), lower manual dynamometric force (OR: 0.96; 95% CI: 0.94, 0.99), shorter ocular axial length (OR: 0.73; 95% CI: 0.56, 0.96), and higher diastolic blood pressure (OR: 1.04; 95% CI: 1.01, 1.06), or alternatively, higher estimated cerebrospinal fluid pressure (OR: 1.09; 95% CI: 1.01, 1.18).Conclusion: In this urban and rural Russian population aged 40+ years, DR prevalence was relatively low (1.9%; 95% CI: 1.6, 2.3), showed an inverted U-shaped association with age, and in a cross-sectional study design it was associated with shorter axial length and higher estimated cerebrospinal fluid pressure.Keywords: diabetic retinopathy, cerebrospinal fluid pressure, myopia, axial length, blindness, ural eye and medical study |
| format |
article |
| author |
Bikbov MM Gilmanshin TR Zainullin RM Kazakbaeva GM Nuriyev IF Zaynetdinov AF Panda-Jonas S Bikbova GM Rakhimova EM Rusakova IA Khalimov TA Safiullina KR Fakhretdinova AA Tuliakova AM Gizzatov AV Jonas JB |
| author_facet |
Bikbov MM Gilmanshin TR Zainullin RM Kazakbaeva GM Nuriyev IF Zaynetdinov AF Panda-Jonas S Bikbova GM Rakhimova EM Rusakova IA Khalimov TA Safiullina KR Fakhretdinova AA Tuliakova AM Gizzatov AV Jonas JB |
| author_sort |
Bikbov MM |
| title |
Prevalence and Associated Factors of Diabetic Retinopathy in a Russian Population. The Ural Eye and Medical Study |
| title_short |
Prevalence and Associated Factors of Diabetic Retinopathy in a Russian Population. The Ural Eye and Medical Study |
| title_full |
Prevalence and Associated Factors of Diabetic Retinopathy in a Russian Population. The Ural Eye and Medical Study |
| title_fullStr |
Prevalence and Associated Factors of Diabetic Retinopathy in a Russian Population. The Ural Eye and Medical Study |
| title_full_unstemmed |
Prevalence and Associated Factors of Diabetic Retinopathy in a Russian Population. The Ural Eye and Medical Study |
| title_sort |
prevalence and associated factors of diabetic retinopathy in a russian population. the ural eye and medical study |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/7b267cab89354295bad4235443e269cb |
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