The impact of mammographic screening on the subsequent breast cancer risk associated with biopsy-proven benign breast disease

Abstract Data on the risk of breast cancer following a benign breast disease (BBD) diagnosis were derived predominantly from populations of women biopsied before the widespread use of mammographic screening and in whom these lesions were mostly incidental findings. Whether or not similar risk associ...

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Autores principales:	Francisco Beca, Hannah Oh, Laura C. Collins, Rulla M. Tamimi, Stuart J. Schnitt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/7b27ac20b33b4b9c8fa08805db1d0012
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spelling	oai:doaj.org-article:7b27ac20b33b4b9c8fa08805db1d00122021-12-02T13:32:53ZThe impact of mammographic screening on the subsequent breast cancer risk associated with biopsy-proven benign breast disease10.1038/s41523-021-00225-92374-4677https://doaj.org/article/7b27ac20b33b4b9c8fa08805db1d00122021-03-01T00:00:00Zhttps://doi.org/10.1038/s41523-021-00225-9https://doaj.org/toc/2374-4677Abstract Data on the risk of breast cancer following a benign breast disease (BBD) diagnosis were derived predominantly from populations of women biopsied before the widespread use of mammographic screening and in whom these lesions were mostly incidental findings. Whether or not similar risk associations are seen when these lesions are detected in mammographically screened populations is unknown. To address this, we examined the variation in BBD and breast cancer risk associations by the calendar time of BBD diagnosis (pre- vs. post-mammography era [before vs. 1985 and after]) in a nested case–control study within the Nurses’ Health Study (NHS) and NHSII BBD subcohort (488 cases; 1908 controls). We performed logistic regression analysis, adjusting for matching factors and potential confounders, to estimate odds ratio (ORs) and 95% confidence interval (CI) for the association between BBD subtype (non-proliferative, proliferative without atypia, proliferative with atypical hyperplasia (AH)) and subsequent breast cancer risk. When compared with non-proliferative lesions, both proliferative lesions without atypia (PWA) and AHs were associated with similar levels of risk in the pre-mammographic (pre) and post-mammographic (post) time periods (PWA: OR [95% CI] = 1.73 [1.27, 2.36] pre vs. 1.12 [0.73, 1.74] post; AH: 4.41 [2.90, 6.70] pre vs. 3.69 [2.21, 6.15] post). The interaction by mammography era was not statistically significant (p-interaction = 0.47). These results suggest that the risk associations reported for BBD subtypes in the pre-mammography era remain valid for BBD detected after the widespread implementation of mammographic screening.Francisco BecaHannah OhLaura C. CollinsRulla M. TamimiStuart J. SchnittNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Breast Cancer, Vol 7, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Francisco Beca Hannah Oh Laura C. Collins Rulla M. Tamimi Stuart J. Schnitt The impact of mammographic screening on the subsequent breast cancer risk associated with biopsy-proven benign breast disease
description	Abstract Data on the risk of breast cancer following a benign breast disease (BBD) diagnosis were derived predominantly from populations of women biopsied before the widespread use of mammographic screening and in whom these lesions were mostly incidental findings. Whether or not similar risk associations are seen when these lesions are detected in mammographically screened populations is unknown. To address this, we examined the variation in BBD and breast cancer risk associations by the calendar time of BBD diagnosis (pre- vs. post-mammography era [before vs. 1985 and after]) in a nested case–control study within the Nurses’ Health Study (NHS) and NHSII BBD subcohort (488 cases; 1908 controls). We performed logistic regression analysis, adjusting for matching factors and potential confounders, to estimate odds ratio (ORs) and 95% confidence interval (CI) for the association between BBD subtype (non-proliferative, proliferative without atypia, proliferative with atypical hyperplasia (AH)) and subsequent breast cancer risk. When compared with non-proliferative lesions, both proliferative lesions without atypia (PWA) and AHs were associated with similar levels of risk in the pre-mammographic (pre) and post-mammographic (post) time periods (PWA: OR [95% CI] = 1.73 [1.27, 2.36] pre vs. 1.12 [0.73, 1.74] post; AH: 4.41 [2.90, 6.70] pre vs. 3.69 [2.21, 6.15] post). The interaction by mammography era was not statistically significant (p-interaction = 0.47). These results suggest that the risk associations reported for BBD subtypes in the pre-mammography era remain valid for BBD detected after the widespread implementation of mammographic screening.
format	article
author	Francisco Beca Hannah Oh Laura C. Collins Rulla M. Tamimi Stuart J. Schnitt
author_facet	Francisco Beca Hannah Oh Laura C. Collins Rulla M. Tamimi Stuart J. Schnitt
author_sort	Francisco Beca
title	The impact of mammographic screening on the subsequent breast cancer risk associated with biopsy-proven benign breast disease
title_short	The impact of mammographic screening on the subsequent breast cancer risk associated with biopsy-proven benign breast disease
title_full	The impact of mammographic screening on the subsequent breast cancer risk associated with biopsy-proven benign breast disease
title_fullStr	The impact of mammographic screening on the subsequent breast cancer risk associated with biopsy-proven benign breast disease
title_full_unstemmed	The impact of mammographic screening on the subsequent breast cancer risk associated with biopsy-proven benign breast disease
title_sort	impact of mammographic screening on the subsequent breast cancer risk associated with biopsy-proven benign breast disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7b27ac20b33b4b9c8fa08805db1d0012
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The impact of mammographic screening on the subsequent breast cancer risk associated with biopsy-proven benign breast disease

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