Misregulation of Wnt Signaling Pathways at the Plasma Membrane in Brain and Metabolic Diseases

Wnt signaling pathways constitute a group of signal transduction pathways that direct many physiological processes, such as development, growth, and differentiation. Dysregulation of these pathways is thus associated with many pathological processes, including neurodegenerative diseases, metabolic d...

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Autores principales:	Mustafa Karabicici, Yagmur Azbazdar, Evin Iscan, Gunes Ozhan
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Wnt signaling pathway plasma membrane ordered domain lipid raft Alzheimer’s disease Parkinson’s disease Chemical technology TP1-1185 Chemical engineering TP155-156
Acceso en línea:	https://doaj.org/article/7b296f0c4190481684d96ab91df5ee9f
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spelling	oai:doaj.org-article:7b296f0c4190481684d96ab91df5ee9f2021-11-25T18:19:45ZMisregulation of Wnt Signaling Pathways at the Plasma Membrane in Brain and Metabolic Diseases10.3390/membranes111108442077-0375https://doaj.org/article/7b296f0c4190481684d96ab91df5ee9f2021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0375/11/11/844https://doaj.org/toc/2077-0375Wnt signaling pathways constitute a group of signal transduction pathways that direct many physiological processes, such as development, growth, and differentiation. Dysregulation of these pathways is thus associated with many pathological processes, including neurodegenerative diseases, metabolic disorders, and cancer. At the same time, alterations are observed in plasma membrane compositions, lipid organizations, and ordered membrane domains in brain and metabolic diseases that are associated with Wnt signaling pathway activation. Here, we discuss the relationships between plasma membrane components—specifically ligands, (co) receptors, and extracellular or membrane-associated modulators—to activate Wnt pathways in several brain and metabolic diseases. Thus, the Wnt–receptor complex can be targeted based on the composition and organization of the plasma membrane, in order to develop effective targeted therapy drugs.Mustafa KarabiciciYagmur AzbazdarEvin IscanGunes OzhanMDPI AGarticleWnt signaling pathwayplasma membraneordered domainlipid raftAlzheimer’s diseaseParkinson’s diseaseChemical technologyTP1-1185Chemical engineeringTP155-156ENMembranes, Vol 11, Iss 844, p 844 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Wnt signaling pathway plasma membrane ordered domain lipid raft Alzheimer’s disease Parkinson’s disease Chemical technology TP1-1185 Chemical engineering TP155-156
spellingShingle	Wnt signaling pathway plasma membrane ordered domain lipid raft Alzheimer’s disease Parkinson’s disease Chemical technology TP1-1185 Chemical engineering TP155-156 Mustafa Karabicici Yagmur Azbazdar Evin Iscan Gunes Ozhan Misregulation of Wnt Signaling Pathways at the Plasma Membrane in Brain and Metabolic Diseases
description	Wnt signaling pathways constitute a group of signal transduction pathways that direct many physiological processes, such as development, growth, and differentiation. Dysregulation of these pathways is thus associated with many pathological processes, including neurodegenerative diseases, metabolic disorders, and cancer. At the same time, alterations are observed in plasma membrane compositions, lipid organizations, and ordered membrane domains in brain and metabolic diseases that are associated with Wnt signaling pathway activation. Here, we discuss the relationships between plasma membrane components—specifically ligands, (co) receptors, and extracellular or membrane-associated modulators—to activate Wnt pathways in several brain and metabolic diseases. Thus, the Wnt–receptor complex can be targeted based on the composition and organization of the plasma membrane, in order to develop effective targeted therapy drugs.
format	article
author	Mustafa Karabicici Yagmur Azbazdar Evin Iscan Gunes Ozhan
author_facet	Mustafa Karabicici Yagmur Azbazdar Evin Iscan Gunes Ozhan
author_sort	Mustafa Karabicici
title	Misregulation of Wnt Signaling Pathways at the Plasma Membrane in Brain and Metabolic Diseases
title_short	Misregulation of Wnt Signaling Pathways at the Plasma Membrane in Brain and Metabolic Diseases
title_full	Misregulation of Wnt Signaling Pathways at the Plasma Membrane in Brain and Metabolic Diseases
title_fullStr	Misregulation of Wnt Signaling Pathways at the Plasma Membrane in Brain and Metabolic Diseases
title_full_unstemmed	Misregulation of Wnt Signaling Pathways at the Plasma Membrane in Brain and Metabolic Diseases
title_sort	misregulation of wnt signaling pathways at the plasma membrane in brain and metabolic diseases
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7b296f0c4190481684d96ab91df5ee9f
work_keys_str_mv	AT mustafakarabicici misregulationofwntsignalingpathwaysattheplasmamembraneinbrainandmetabolicdiseases AT yagmurazbazdar misregulationofwntsignalingpathwaysattheplasmamembraneinbrainandmetabolicdiseases AT eviniscan misregulationofwntsignalingpathwaysattheplasmamembraneinbrainandmetabolicdiseases AT gunesozhan misregulationofwntsignalingpathwaysattheplasmamembraneinbrainandmetabolicdiseases
_version_	1718411328869105664

Misregulation of Wnt Signaling Pathways at the Plasma Membrane in Brain and Metabolic Diseases

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