CCT complex restricts neuropathogenic protein aggregation via autophagy

The CCT complex, a key player in the chaperone machinery, has been implicated in Huntington’s disease. Pavelet al. show that CCT2/5/7 also play an essential role in autophagosome degradation, and that the aggregation of proteins upon CCT2/5/7 depletion is primarily a consequence of impaired autophag...

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Autores principales:	Mariana Pavel, Sara Imarisio, Fiona M. Menzies, Maria Jimenez-Sanchez, Farah H. Siddiqi, Xiaoting Wu, Maurizio Renna, Cahir J. O’Kane, Damian C. Crowther, David C. Rubinsztein
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7b2b3980bb0d47cfbbc1901e8b838972
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spelling	oai:doaj.org-article:7b2b3980bb0d47cfbbc1901e8b8389722021-12-02T16:49:57ZCCT complex restricts neuropathogenic protein aggregation via autophagy10.1038/ncomms138212041-1723https://doaj.org/article/7b2b3980bb0d47cfbbc1901e8b8389722016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13821https://doaj.org/toc/2041-1723The CCT complex, a key player in the chaperone machinery, has been implicated in Huntington’s disease. Pavelet al. show that CCT2/5/7 also play an essential role in autophagosome degradation, and that the aggregation of proteins upon CCT2/5/7 depletion is primarily a consequence of impaired autophagy.Mariana PavelSara ImarisioFiona M. MenziesMaria Jimenez-SanchezFarah H. SiddiqiXiaoting WuMaurizio RennaCahir J. O’KaneDamian C. CrowtherDavid C. RubinszteinNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-18 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mariana Pavel Sara Imarisio Fiona M. Menzies Maria Jimenez-Sanchez Farah H. Siddiqi Xiaoting Wu Maurizio Renna Cahir J. O’Kane Damian C. Crowther David C. Rubinsztein CCT complex restricts neuropathogenic protein aggregation via autophagy
description	The CCT complex, a key player in the chaperone machinery, has been implicated in Huntington’s disease. Pavelet al. show that CCT2/5/7 also play an essential role in autophagosome degradation, and that the aggregation of proteins upon CCT2/5/7 depletion is primarily a consequence of impaired autophagy.
format	article
author	Mariana Pavel Sara Imarisio Fiona M. Menzies Maria Jimenez-Sanchez Farah H. Siddiqi Xiaoting Wu Maurizio Renna Cahir J. O’Kane Damian C. Crowther David C. Rubinsztein
author_facet	Mariana Pavel Sara Imarisio Fiona M. Menzies Maria Jimenez-Sanchez Farah H. Siddiqi Xiaoting Wu Maurizio Renna Cahir J. O’Kane Damian C. Crowther David C. Rubinsztein
author_sort	Mariana Pavel
title	CCT complex restricts neuropathogenic protein aggregation via autophagy
title_short	CCT complex restricts neuropathogenic protein aggregation via autophagy
title_full	CCT complex restricts neuropathogenic protein aggregation via autophagy
title_fullStr	CCT complex restricts neuropathogenic protein aggregation via autophagy
title_full_unstemmed	CCT complex restricts neuropathogenic protein aggregation via autophagy
title_sort	cct complex restricts neuropathogenic protein aggregation via autophagy
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/7b2b3980bb0d47cfbbc1901e8b838972
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CCT complex restricts neuropathogenic protein aggregation via autophagy

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