CCT complex restricts neuropathogenic protein aggregation via autophagy

CCT complex restricts neuropathogenic protein aggregation via autophagy

The CCT complex, a key player in the chaperone machinery, has been implicated in Huntington’s disease. Pavelet al. show that CCT2/5/7 also play an essential role in autophagosome degradation, and that the aggregation of proteins upon CCT2/5/7 depletion is primarily a consequence of impaired autophag...

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Autores principales: Mariana Pavel, Sara Imarisio, Fiona M. Menzies, Maria Jimenez-Sanchez, Farah H. Siddiqi, Xiaoting Wu, Maurizio Renna, Cahir J. O’Kane, Damian C. Crowther, David C. Rubinsztein
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/7b2b3980bb0d47cfbbc1901e8b838972
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