Association Between High-Sensitivity Troponin T on Admission and Organ Dysfunction During Hospitalization in Patients Aged 80 Years and Older with Hip Fracture: A Single-Centered Prospective Cohort Study

Zhi-Jun Qin,1 Qian-Yun Wu,1 Yang Deng,1 Xia Li,2 Xuan-Di Wei,2 Cheng-Jie Tang,3 Jun-Feng Jia3 1Department of Intensive Care Unit, Sichuan Provincial Orthopedic Hospital, Chengdu, Sichuan, People’s Republic of China; 2Department of General Medicine, Sichuan Provincial Orthopedic Hospital, C...

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Autores principales:	Qin ZJ, Wu QY, Deng Y, Li X, Wei XD, Tang CJ, Jia JF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	high-sensitivity troponin t hip fracture multiple organ dysfunction syndrome in the elderly short-term outcomes Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/7b340532070e484a8ce5d03692bf84ce
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spelling	oai:doaj.org-article:7b340532070e484a8ce5d03692bf84ce2021-12-02T16:36:58ZAssociation Between High-Sensitivity Troponin T on Admission and Organ Dysfunction During Hospitalization in Patients Aged 80 Years and Older with Hip Fracture: A Single-Centered Prospective Cohort Study1178-1998https://doaj.org/article/7b340532070e484a8ce5d03692bf84ce2021-04-01T00:00:00Zhttps://www.dovepress.com/association-between-high-sensitivity-troponin-t-on-admission-and-organ-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Zhi-Jun Qin,1 Qian-Yun Wu,1 Yang Deng,1 Xia Li,2 Xuan-Di Wei,2 Cheng-Jie Tang,3 Jun-Feng Jia3 1Department of Intensive Care Unit, Sichuan Provincial Orthopedic Hospital, Chengdu, Sichuan, People’s Republic of China; 2Department of General Medicine, Sichuan Provincial Orthopedic Hospital, Chengdu, Sichuan, People’s Republic of China; 3Department of Geriatric Orthopedics, Sichuan Provincial Orthopedic Hospital, Chengdu, Sichuan, People’s Republic of ChinaCorrespondence: Zhi-Jun QinDepartment of Intensive Care Unit, Sichuan Provincial Orthopedic Hospital, No. 132, West First Section, First Ring Road, Chengdu City, Sichuan Province, 610041, People’s Republic of ChinaTel +86 − 18728179291Email qin18716111836@126.comBackground: Prognostic evaluation of elderly patients with hip fracture is an issue that has been highly concerned by clinicians. Only a few studies have focused on organ dysfunction after hip fracture in the elderly. This study aimed to investigate the association between high-sensitivity troponin T (hs-TnT) at admission and organ dysfunction during hospitalization in elderly patients with hip fracture.Methods: We enrolled 168 patients with hip fracture who were aged 80 years and older at Geriatric Orthopaedic Center of Sichuan Provincial Orthopedic Hospital between January 2020 and August 2020. Baseline characteristics, perioperative information, and short-term clinical outcomes were analyzed.Results: Of the 208 patients admitted during the study period, 168 met the inclusion criteria; of these, 91 (54.2%) had higher hs-TnT than the 99th percentile in the normal population. After adjustment for confounders, elevated hs-TnT was independently associated with multiple organ dysfunction syndrome in the elderly (MODSE) (adjusted OR, 5.76; 95% CI, 1.74– 19.10; P = 0.004), heart dysfunction (adjusted OR, 7.48; 95% CI, 2.17– 25.82; P = 0.001), MODS severity score > 3 (adjusted OR, 5.22; 95% CI, 1.32– 20.60; P = 0.018), and length of hospital stay > 14 days (adjusted OR, 2.38; 95% CI, 1.05– 5.36; P = 0.037).Conclusion: Increased hs-TnT on admission is an independent risk factor for MODSE after hip fracture in patients aged 80 years and older. Effective measures should be applied to avoid progression of MODSE from pre-failure stage to failure stage.Keywords: high-sensitivity troponin T, hip fracture, multiple organ dysfunction syndrome in the elderly, short-term outcomesQin ZJWu QYDeng YLi XWei XDTang CJJia JFDove Medical Pressarticlehigh-sensitivity troponin thip fracturemultiple organ dysfunction syndrome in the elderlyshort-term outcomesGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 16, Pp 583-591 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	high-sensitivity troponin t hip fracture multiple organ dysfunction syndrome in the elderly short-term outcomes Geriatrics RC952-954.6
spellingShingle	high-sensitivity troponin t hip fracture multiple organ dysfunction syndrome in the elderly short-term outcomes Geriatrics RC952-954.6 Qin ZJ Wu QY Deng Y Li X Wei XD Tang CJ Jia JF Association Between High-Sensitivity Troponin T on Admission and Organ Dysfunction During Hospitalization in Patients Aged 80 Years and Older with Hip Fracture: A Single-Centered Prospective Cohort Study
description	Zhi-Jun Qin,1 Qian-Yun Wu,1 Yang Deng,1 Xia Li,2 Xuan-Di Wei,2 Cheng-Jie Tang,3 Jun-Feng Jia3 1Department of Intensive Care Unit, Sichuan Provincial Orthopedic Hospital, Chengdu, Sichuan, People’s Republic of China; 2Department of General Medicine, Sichuan Provincial Orthopedic Hospital, Chengdu, Sichuan, People’s Republic of China; 3Department of Geriatric Orthopedics, Sichuan Provincial Orthopedic Hospital, Chengdu, Sichuan, People’s Republic of ChinaCorrespondence: Zhi-Jun QinDepartment of Intensive Care Unit, Sichuan Provincial Orthopedic Hospital, No. 132, West First Section, First Ring Road, Chengdu City, Sichuan Province, 610041, People’s Republic of ChinaTel +86 − 18728179291Email qin18716111836@126.comBackground: Prognostic evaluation of elderly patients with hip fracture is an issue that has been highly concerned by clinicians. Only a few studies have focused on organ dysfunction after hip fracture in the elderly. This study aimed to investigate the association between high-sensitivity troponin T (hs-TnT) at admission and organ dysfunction during hospitalization in elderly patients with hip fracture.Methods: We enrolled 168 patients with hip fracture who were aged 80 years and older at Geriatric Orthopaedic Center of Sichuan Provincial Orthopedic Hospital between January 2020 and August 2020. Baseline characteristics, perioperative information, and short-term clinical outcomes were analyzed.Results: Of the 208 patients admitted during the study period, 168 met the inclusion criteria; of these, 91 (54.2%) had higher hs-TnT than the 99th percentile in the normal population. After adjustment for confounders, elevated hs-TnT was independently associated with multiple organ dysfunction syndrome in the elderly (MODSE) (adjusted OR, 5.76; 95% CI, 1.74– 19.10; P = 0.004), heart dysfunction (adjusted OR, 7.48; 95% CI, 2.17– 25.82; P = 0.001), MODS severity score > 3 (adjusted OR, 5.22; 95% CI, 1.32– 20.60; P = 0.018), and length of hospital stay > 14 days (adjusted OR, 2.38; 95% CI, 1.05– 5.36; P = 0.037).Conclusion: Increased hs-TnT on admission is an independent risk factor for MODSE after hip fracture in patients aged 80 years and older. Effective measures should be applied to avoid progression of MODSE from pre-failure stage to failure stage.Keywords: high-sensitivity troponin T, hip fracture, multiple organ dysfunction syndrome in the elderly, short-term outcomes
format	article
author	Qin ZJ Wu QY Deng Y Li X Wei XD Tang CJ Jia JF
author_facet	Qin ZJ Wu QY Deng Y Li X Wei XD Tang CJ Jia JF
author_sort	Qin ZJ
title	Association Between High-Sensitivity Troponin T on Admission and Organ Dysfunction During Hospitalization in Patients Aged 80 Years and Older with Hip Fracture: A Single-Centered Prospective Cohort Study
title_short	Association Between High-Sensitivity Troponin T on Admission and Organ Dysfunction During Hospitalization in Patients Aged 80 Years and Older with Hip Fracture: A Single-Centered Prospective Cohort Study
title_full	Association Between High-Sensitivity Troponin T on Admission and Organ Dysfunction During Hospitalization in Patients Aged 80 Years and Older with Hip Fracture: A Single-Centered Prospective Cohort Study
title_fullStr	Association Between High-Sensitivity Troponin T on Admission and Organ Dysfunction During Hospitalization in Patients Aged 80 Years and Older with Hip Fracture: A Single-Centered Prospective Cohort Study
title_full_unstemmed	Association Between High-Sensitivity Troponin T on Admission and Organ Dysfunction During Hospitalization in Patients Aged 80 Years and Older with Hip Fracture: A Single-Centered Prospective Cohort Study
title_sort	association between high-sensitivity troponin t on admission and organ dysfunction during hospitalization in patients aged 80 years and older with hip fracture: a single-centered prospective cohort study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/7b340532070e484a8ce5d03692bf84ce
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Association Between High-Sensitivity Troponin T on Admission and Organ Dysfunction During Hospitalization in Patients Aged 80 Years and Older with Hip Fracture: A Single-Centered Prospective Cohort Study

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