GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer
Thyroid stimulating hormone (TSH) is critical for normal development and metabolism. Here, the authors conduct a GWAS and suggest protective effect of higher TSH on risk of thyroid cancer and goitre.
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| Lenguaje: | EN |
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Nature Portfolio
2020
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oai:doaj.org-article:7b39ae688f264dfba9a4f0d7009abe4e2021-12-02T14:53:37ZGWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer10.1038/s41467-020-17718-z2041-1723https://doaj.org/article/7b39ae688f264dfba9a4f0d7009abe4e2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17718-zhttps://doaj.org/toc/2041-1723Thyroid stimulating hormone (TSH) is critical for normal development and metabolism. Here, the authors conduct a GWAS and suggest protective effect of higher TSH on risk of thyroid cancer and goitre.Wei ZhouBen BrumptonOmer KabilJulius GudmundssonGudmar ThorleifssonJosh WeinstockMatthew ZawistowskiJonas B. NielsenLayal ChakerMarco MediciAlexander TeumerSilvia NaitzaSerena SannaUlla T. SchultheissAnne CappolaJuha KarjalainenMitja KurkiMorgan OnekaPeter TaylorLars G. FritscheSarah E. GrahamBrooke N. WolfordWilliam OvertonHumaira RasheedEirin B. HaugMaiken E. GabrielsenAnne Heidi SkogholtIda SurakkaGeorge Davey SmithAnita PanditTanmoy RoychowdhuryWhitney E. HornsbyJon G. JonassonLeigha SenterSandya LiyanarachchiMatthew D. RingelLi XuLambertus A. KiemeneyHuiling HeRomana T. Netea-MaierJose I. MayordomoTheo S. PlantingaJon HrafnkelssonHannes HjartarsonErich M. SturgisAarno PalotieMark DalyCintia E. CitterioPeter ArvanChad M. BrummettMichael BoehnkeAlbert de la ChapelleKari StefanssonKristian HveemCristen J. WillerBjørn Olav ÅsvoldNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020) |
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DOAJ |
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DOAJ |
| language |
EN |
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Science Q |
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Science Q Wei Zhou Ben Brumpton Omer Kabil Julius Gudmundsson Gudmar Thorleifsson Josh Weinstock Matthew Zawistowski Jonas B. Nielsen Layal Chaker Marco Medici Alexander Teumer Silvia Naitza Serena Sanna Ulla T. Schultheiss Anne Cappola Juha Karjalainen Mitja Kurki Morgan Oneka Peter Taylor Lars G. Fritsche Sarah E. Graham Brooke N. Wolford William Overton Humaira Rasheed Eirin B. Haug Maiken E. Gabrielsen Anne Heidi Skogholt Ida Surakka George Davey Smith Anita Pandit Tanmoy Roychowdhury Whitney E. Hornsby Jon G. Jonasson Leigha Senter Sandya Liyanarachchi Matthew D. Ringel Li Xu Lambertus A. Kiemeney Huiling He Romana T. Netea-Maier Jose I. Mayordomo Theo S. Plantinga Jon Hrafnkelsson Hannes Hjartarson Erich M. Sturgis Aarno Palotie Mark Daly Cintia E. Citterio Peter Arvan Chad M. Brummett Michael Boehnke Albert de la Chapelle Kari Stefansson Kristian Hveem Cristen J. Willer Bjørn Olav Åsvold GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer |
| description |
Thyroid stimulating hormone (TSH) is critical for normal development and metabolism. Here, the authors conduct a GWAS and suggest protective effect of higher TSH on risk of thyroid cancer and goitre. |
| format |
article |
| author |
Wei Zhou Ben Brumpton Omer Kabil Julius Gudmundsson Gudmar Thorleifsson Josh Weinstock Matthew Zawistowski Jonas B. Nielsen Layal Chaker Marco Medici Alexander Teumer Silvia Naitza Serena Sanna Ulla T. Schultheiss Anne Cappola Juha Karjalainen Mitja Kurki Morgan Oneka Peter Taylor Lars G. Fritsche Sarah E. Graham Brooke N. Wolford William Overton Humaira Rasheed Eirin B. Haug Maiken E. Gabrielsen Anne Heidi Skogholt Ida Surakka George Davey Smith Anita Pandit Tanmoy Roychowdhury Whitney E. Hornsby Jon G. Jonasson Leigha Senter Sandya Liyanarachchi Matthew D. Ringel Li Xu Lambertus A. Kiemeney Huiling He Romana T. Netea-Maier Jose I. Mayordomo Theo S. Plantinga Jon Hrafnkelsson Hannes Hjartarson Erich M. Sturgis Aarno Palotie Mark Daly Cintia E. Citterio Peter Arvan Chad M. Brummett Michael Boehnke Albert de la Chapelle Kari Stefansson Kristian Hveem Cristen J. Willer Bjørn Olav Åsvold |
| author_facet |
Wei Zhou Ben Brumpton Omer Kabil Julius Gudmundsson Gudmar Thorleifsson Josh Weinstock Matthew Zawistowski Jonas B. Nielsen Layal Chaker Marco Medici Alexander Teumer Silvia Naitza Serena Sanna Ulla T. Schultheiss Anne Cappola Juha Karjalainen Mitja Kurki Morgan Oneka Peter Taylor Lars G. Fritsche Sarah E. Graham Brooke N. Wolford William Overton Humaira Rasheed Eirin B. Haug Maiken E. Gabrielsen Anne Heidi Skogholt Ida Surakka George Davey Smith Anita Pandit Tanmoy Roychowdhury Whitney E. Hornsby Jon G. Jonasson Leigha Senter Sandya Liyanarachchi Matthew D. Ringel Li Xu Lambertus A. Kiemeney Huiling He Romana T. Netea-Maier Jose I. Mayordomo Theo S. Plantinga Jon Hrafnkelsson Hannes Hjartarson Erich M. Sturgis Aarno Palotie Mark Daly Cintia E. Citterio Peter Arvan Chad M. Brummett Michael Boehnke Albert de la Chapelle Kari Stefansson Kristian Hveem Cristen J. Willer Bjørn Olav Åsvold |
| author_sort |
Wei Zhou |
| title |
GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer |
| title_short |
GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer |
| title_full |
GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer |
| title_fullStr |
GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer |
| title_full_unstemmed |
GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer |
| title_sort |
gwas of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/7b39ae688f264dfba9a4f0d7009abe4e |
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