Trends in Incidence and Clinical Outcomes of Clostridioides difficile Infection, Hong Kong
We conducted a territorywide survey to investigate the epidemiology, risk factors, and clinical outcomes of Clostridioides difficile infection (CDI) among hospitalized patients in Hong Kong. A total of 17,105 cases of CDI were identified, of which 15,717 (91.9%) were healthcare-associated and 1,025...
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Centers for Disease Control and Prevention
2021
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oai:doaj.org-article:7b3b80364d4f489c88ddb93f61ac8ab32021-11-22T12:56:56ZTrends in Incidence and Clinical Outcomes of Clostridioides difficile Infection, Hong Kong10.3201/eid2712.2037691080-60401080-6059https://doaj.org/article/7b3b80364d4f489c88ddb93f61ac8ab32021-12-01T00:00:00Zhttps://wwwnc.cdc.gov/eid/article/27/12/20-3769_articlehttps://doaj.org/toc/1080-6040https://doaj.org/toc/1080-6059 We conducted a territorywide survey to investigate the epidemiology, risk factors, and clinical outcomes of Clostridioides difficile infection (CDI) among hospitalized patients in Hong Kong. A total of 17,105 cases of CDI were identified, of which 15,717 (91.9%) were healthcare-associated and 1,025 (6.0%) were community-associated. Although CDI incidence increased substantially from 2006 to 2017, it plateaued in 2018 and 2019. The 30-day mortality rates decreased from 20.1% in 2015 to 16.8% in 2019, whereas the 60-day recurrence rates remained constant at ≈11% during the study period. Cross-correlation statistic showed significant correlations between incidence trend and overall antimicrobial drug use (r = 0.865, p<0.001), which has decreased as a result of an antibiotic stewardship program initiated in 2017. Our data suggest a turning point in C. difficile epidemiology that could be related to the changing pattern of antimicrobial drug use. Cosmos L.T. GuoThomas N.Y. KwongJoyce W.Y. MakLin ZhangGrace C.Y. LuiGrace L.H. WongMargaret IpJun YuJoseph J.Y. SungWilliam K.K. WuSunny H. WongCenters for Disease Control and PreventionarticleClostridioides difficilepseudomembranous colitisantimicrobial resistanceepidemiologysurveillanceHong KongMedicineRInfectious and parasitic diseasesRC109-216ENEmerging Infectious Diseases, Vol 27, Iss 12, Pp 3036-3044 (2021) |
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DOAJ |
| language |
EN |
| topic |
Clostridioides difficile pseudomembranous colitis antimicrobial resistance epidemiology surveillance Hong Kong Medicine R Infectious and parasitic diseases RC109-216 |
| spellingShingle |
Clostridioides difficile pseudomembranous colitis antimicrobial resistance epidemiology surveillance Hong Kong Medicine R Infectious and parasitic diseases RC109-216 Cosmos L.T. Guo Thomas N.Y. Kwong Joyce W.Y. Mak Lin Zhang Grace C.Y. Lui Grace L.H. Wong Margaret Ip Jun Yu Joseph J.Y. Sung William K.K. Wu Sunny H. Wong Trends in Incidence and Clinical Outcomes of Clostridioides difficile Infection, Hong Kong |
| description |
We conducted a territorywide survey to investigate the epidemiology, risk factors, and clinical outcomes of Clostridioides difficile infection (CDI) among hospitalized patients in Hong Kong. A total of 17,105 cases of CDI were identified, of which 15,717 (91.9%) were healthcare-associated and 1,025 (6.0%) were community-associated. Although CDI incidence increased substantially from 2006 to 2017, it plateaued in 2018 and 2019. The 30-day mortality rates decreased from 20.1% in 2015 to 16.8% in 2019, whereas the 60-day recurrence rates remained constant at ≈11% during the study period. Cross-correlation statistic showed significant correlations between incidence trend and overall antimicrobial drug use (r = 0.865, p<0.001), which has decreased as a result of an antibiotic stewardship program initiated in 2017. Our data suggest a turning point in C. difficile epidemiology that could be related to the changing pattern of antimicrobial drug use.
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| format |
article |
| author |
Cosmos L.T. Guo Thomas N.Y. Kwong Joyce W.Y. Mak Lin Zhang Grace C.Y. Lui Grace L.H. Wong Margaret Ip Jun Yu Joseph J.Y. Sung William K.K. Wu Sunny H. Wong |
| author_facet |
Cosmos L.T. Guo Thomas N.Y. Kwong Joyce W.Y. Mak Lin Zhang Grace C.Y. Lui Grace L.H. Wong Margaret Ip Jun Yu Joseph J.Y. Sung William K.K. Wu Sunny H. Wong |
| author_sort |
Cosmos L.T. Guo |
| title |
Trends in Incidence and Clinical Outcomes of Clostridioides difficile Infection, Hong Kong |
| title_short |
Trends in Incidence and Clinical Outcomes of Clostridioides difficile Infection, Hong Kong |
| title_full |
Trends in Incidence and Clinical Outcomes of Clostridioides difficile Infection, Hong Kong |
| title_fullStr |
Trends in Incidence and Clinical Outcomes of Clostridioides difficile Infection, Hong Kong |
| title_full_unstemmed |
Trends in Incidence and Clinical Outcomes of Clostridioides difficile Infection, Hong Kong |
| title_sort |
trends in incidence and clinical outcomes of clostridioides difficile infection, hong kong |
| publisher |
Centers for Disease Control and Prevention |
| publishDate |
2021 |
| url |
https://doaj.org/article/7b3b80364d4f489c88ddb93f61ac8ab3 |
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