The Roles of RNA N6-Methyladenosine in Regulating Stem Cell Fate

RNA N6-methyladenosine (m6A) modification has important regulatory roles in determining cell fate. The reversible methylation process of adding and removing m6A marks is dynamically regulated by a fine-tuned coordination of many enzymes and binding proteins. Stem cells have self-renewal and pluripot...

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Autores principales:	Runbi Ji, Xu Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	N6-methyladenosine post-transcriptional modifications cancer stem cell cell differentiation Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/7b3bb3788a894f34ae143ce7d02c96ab
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spelling	oai:doaj.org-article:7b3bb3788a894f34ae143ce7d02c96ab2021-11-05T07:51:27ZThe Roles of RNA N6-Methyladenosine in Regulating Stem Cell Fate2296-634X10.3389/fcell.2021.765635https://doaj.org/article/7b3bb3788a894f34ae143ce7d02c96ab2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.765635/fullhttps://doaj.org/toc/2296-634XRNA N6-methyladenosine (m6A) modification has important regulatory roles in determining cell fate. The reversible methylation process of adding and removing m6A marks is dynamically regulated by a fine-tuned coordination of many enzymes and binding proteins. Stem cells have self-renewal and pluripotent potential and show broad prospects in regenerative medicine and other fields. Stem cells have also been identified in cancer, which is linked to cancer metastasis, therapy resistance, and recurrence. Herein, we aimed to review the molecular mechanism that controls the reversible balance of m6A level in stem cells and the effect of m6A modification on the balance between pluripotency and differentiation. Additionally, we also elaborated the association between aberrant m6A modification and the maintenance of cancer stem cells in many cancers. Moreover, we discussed about the clinical implications of m6A modification in cancer stem cells for cancer diagnosis and therapy.Runbi JiRunbi JiXu ZhangFrontiers Media S.A.articleN6-methyladenosinepost-transcriptional modificationscancerstem cellcell differentiationBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	N6-methyladenosine post-transcriptional modifications cancer stem cell cell differentiation Biology (General) QH301-705.5
spellingShingle	N6-methyladenosine post-transcriptional modifications cancer stem cell cell differentiation Biology (General) QH301-705.5 Runbi Ji Runbi Ji Xu Zhang The Roles of RNA N6-Methyladenosine in Regulating Stem Cell Fate
description	RNA N6-methyladenosine (m6A) modification has important regulatory roles in determining cell fate. The reversible methylation process of adding and removing m6A marks is dynamically regulated by a fine-tuned coordination of many enzymes and binding proteins. Stem cells have self-renewal and pluripotent potential and show broad prospects in regenerative medicine and other fields. Stem cells have also been identified in cancer, which is linked to cancer metastasis, therapy resistance, and recurrence. Herein, we aimed to review the molecular mechanism that controls the reversible balance of m6A level in stem cells and the effect of m6A modification on the balance between pluripotency and differentiation. Additionally, we also elaborated the association between aberrant m6A modification and the maintenance of cancer stem cells in many cancers. Moreover, we discussed about the clinical implications of m6A modification in cancer stem cells for cancer diagnosis and therapy.
format	article
author	Runbi Ji Runbi Ji Xu Zhang
author_facet	Runbi Ji Runbi Ji Xu Zhang
author_sort	Runbi Ji
title	The Roles of RNA N6-Methyladenosine in Regulating Stem Cell Fate
title_short	The Roles of RNA N6-Methyladenosine in Regulating Stem Cell Fate
title_full	The Roles of RNA N6-Methyladenosine in Regulating Stem Cell Fate
title_fullStr	The Roles of RNA N6-Methyladenosine in Regulating Stem Cell Fate
title_full_unstemmed	The Roles of RNA N6-Methyladenosine in Regulating Stem Cell Fate
title_sort	roles of rna n6-methyladenosine in regulating stem cell fate
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/7b3bb3788a894f34ae143ce7d02c96ab
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The Roles of RNA N6-Methyladenosine in Regulating Stem Cell Fate

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