Prevalence of HCV genotypes and subtypes in Southeast Asia: A systematic review and meta-analysis.

Known for its high genetic diversity and variation in genotypic presence in different regions of the world, hepatitis C virus (HCV) is estimated to infect about 71 million people globally. Selection of an appropriate therapeutic regimen largely depends on the identification of the genotype responsib...

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Autores principales: Ahmad Adebayo Irekeola, Nurul Adila Malek, Yusuf Wada, Nazri Mustaffa, Nur Izat Muhamad, Rafidah Hanim Shueb
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Publicado: Public Library of Science (PLoS) 2021
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spelling oai:doaj.org-article:7b3ca2e45629462cb260ee6e8fd701362021-11-25T06:19:04ZPrevalence of HCV genotypes and subtypes in Southeast Asia: A systematic review and meta-analysis.1932-620310.1371/journal.pone.0251673https://doaj.org/article/7b3ca2e45629462cb260ee6e8fd701362021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0251673https://doaj.org/toc/1932-6203Known for its high genetic diversity and variation in genotypic presence in different regions of the world, hepatitis C virus (HCV) is estimated to infect about 71 million people globally. Selection of an appropriate therapeutic regimen largely depends on the identification of the genotype responsible for the infection. This systematic review and meta-analysis was conducted to provide a comprehensive view of HCV genotype and subtype distribution in Southeast Asia (SEA). The review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA). We searched five databases without year and language restrictions. Data from 90 eligible studies involving 15,089 genotypes and 9,646 subtypes representing 10 SEA countries were analyzed. The pooled estimates showed that genotype 1 (46.8%) [95% CI, 43.2-50.4; I2 = 92.77%; p < 0.001] was the most dominant HCV genotype in the region, followed by genotype 3 (23.1%) [95% CI, 19.4-27.2; I2 = 93.03%; p < 0.001], genotype 6 (16.5%) [95% CI, 13.8-19.6], genotype 2 (4.6%) [95% CI, 3.5-5.9], genotype 4 (1.1%) [95% CI, 0.7-1.5] and genotype 5 (0.8%) [95% CI, 0.4-1.3]. Philippines had the highest prevalence of genotypes 1 and 2. Genotype 6 became more prevalent after year 2000. Over 40 different subtypes were identified, with subtypes 1b (26.3%), 1a (21.3%), and 3a (14.3%) being the most prevalent of all the reported subtypes. Although on a global scale, genotype 6 is considered highly prevalent in SEA, evidence from this study reveals that it is the third most prevalent genotype within the region.Ahmad Adebayo IrekeolaNurul Adila MalekYusuf WadaNazri MustaffaNur Izat MuhamadRafidah Hanim ShuebPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0251673 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Ahmad Adebayo Irekeola
Nurul Adila Malek
Yusuf Wada
Nazri Mustaffa
Nur Izat Muhamad
Rafidah Hanim Shueb
Prevalence of HCV genotypes and subtypes in Southeast Asia: A systematic review and meta-analysis.
description Known for its high genetic diversity and variation in genotypic presence in different regions of the world, hepatitis C virus (HCV) is estimated to infect about 71 million people globally. Selection of an appropriate therapeutic regimen largely depends on the identification of the genotype responsible for the infection. This systematic review and meta-analysis was conducted to provide a comprehensive view of HCV genotype and subtype distribution in Southeast Asia (SEA). The review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA). We searched five databases without year and language restrictions. Data from 90 eligible studies involving 15,089 genotypes and 9,646 subtypes representing 10 SEA countries were analyzed. The pooled estimates showed that genotype 1 (46.8%) [95% CI, 43.2-50.4; I2 = 92.77%; p < 0.001] was the most dominant HCV genotype in the region, followed by genotype 3 (23.1%) [95% CI, 19.4-27.2; I2 = 93.03%; p < 0.001], genotype 6 (16.5%) [95% CI, 13.8-19.6], genotype 2 (4.6%) [95% CI, 3.5-5.9], genotype 4 (1.1%) [95% CI, 0.7-1.5] and genotype 5 (0.8%) [95% CI, 0.4-1.3]. Philippines had the highest prevalence of genotypes 1 and 2. Genotype 6 became more prevalent after year 2000. Over 40 different subtypes were identified, with subtypes 1b (26.3%), 1a (21.3%), and 3a (14.3%) being the most prevalent of all the reported subtypes. Although on a global scale, genotype 6 is considered highly prevalent in SEA, evidence from this study reveals that it is the third most prevalent genotype within the region.
format article
author Ahmad Adebayo Irekeola
Nurul Adila Malek
Yusuf Wada
Nazri Mustaffa
Nur Izat Muhamad
Rafidah Hanim Shueb
author_facet Ahmad Adebayo Irekeola
Nurul Adila Malek
Yusuf Wada
Nazri Mustaffa
Nur Izat Muhamad
Rafidah Hanim Shueb
author_sort Ahmad Adebayo Irekeola
title Prevalence of HCV genotypes and subtypes in Southeast Asia: A systematic review and meta-analysis.
title_short Prevalence of HCV genotypes and subtypes in Southeast Asia: A systematic review and meta-analysis.
title_full Prevalence of HCV genotypes and subtypes in Southeast Asia: A systematic review and meta-analysis.
title_fullStr Prevalence of HCV genotypes and subtypes in Southeast Asia: A systematic review and meta-analysis.
title_full_unstemmed Prevalence of HCV genotypes and subtypes in Southeast Asia: A systematic review and meta-analysis.
title_sort prevalence of hcv genotypes and subtypes in southeast asia: a systematic review and meta-analysis.
publisher Public Library of Science (PLoS)
publishDate 2021
url https://doaj.org/article/7b3ca2e45629462cb260ee6e8fd70136
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