PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia

Arteriovenous malformations (AVM) is a hallmark of hereditary haemorrhagic telangiectasia type 2, a disease caused by mutations in BMP receptor ALK1. Ola et al. show that AVM can be caused by blocking BMP9 and BMP10 in mice, leading to increased VEGF and PI3K activity, and that pharmacologic inhibit...

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Autores principales:	Roxana Ola, Alexandre Dubrac, Jinah Han, Feng Zhang, Jennifer S. Fang, Bruno Larrivée, Monica Lee, Ana A. Urarte, Jan R. Kraehling, Gael Genet, Karen K. Hirschi, William C. Sessa, Francesc V. Canals, Mariona Graupera, Minhong Yan, Lawrence H. Young, Paul S. Oh, Anne Eichmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7b411bab54424730b576b6b6c001bd4f
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spelling	oai:doaj.org-article:7b411bab54424730b576b6b6c001bd4f2021-12-02T14:40:11ZPI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia10.1038/ncomms136502041-1723https://doaj.org/article/7b411bab54424730b576b6b6c001bd4f2016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13650https://doaj.org/toc/2041-1723Arteriovenous malformations (AVM) is a hallmark of hereditary haemorrhagic telangiectasia type 2, a disease caused by mutations in BMP receptor ALK1. Ola et al. show that AVM can be caused by blocking BMP9 and BMP10 in mice, leading to increased VEGF and PI3K activity, and that pharmacologic inhibition of PI3K prevents AVM development.Roxana OlaAlexandre DubracJinah HanFeng ZhangJennifer S. FangBruno LarrivéeMonica LeeAna A. UrarteJan R. KraehlingGael GenetKaren K. HirschiWilliam C. SessaFrancesc V. CanalsMariona GrauperaMinhong YanLawrence H. YoungPaul S. OhAnne EichmannNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Roxana Ola Alexandre Dubrac Jinah Han Feng Zhang Jennifer S. Fang Bruno Larrivée Monica Lee Ana A. Urarte Jan R. Kraehling Gael Genet Karen K. Hirschi William C. Sessa Francesc V. Canals Mariona Graupera Minhong Yan Lawrence H. Young Paul S. Oh Anne Eichmann PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia
description	Arteriovenous malformations (AVM) is a hallmark of hereditary haemorrhagic telangiectasia type 2, a disease caused by mutations in BMP receptor ALK1. Ola et al. show that AVM can be caused by blocking BMP9 and BMP10 in mice, leading to increased VEGF and PI3K activity, and that pharmacologic inhibition of PI3K prevents AVM development.
format	article
author	Roxana Ola Alexandre Dubrac Jinah Han Feng Zhang Jennifer S. Fang Bruno Larrivée Monica Lee Ana A. Urarte Jan R. Kraehling Gael Genet Karen K. Hirschi William C. Sessa Francesc V. Canals Mariona Graupera Minhong Yan Lawrence H. Young Paul S. Oh Anne Eichmann
author_facet	Roxana Ola Alexandre Dubrac Jinah Han Feng Zhang Jennifer S. Fang Bruno Larrivée Monica Lee Ana A. Urarte Jan R. Kraehling Gael Genet Karen K. Hirschi William C. Sessa Francesc V. Canals Mariona Graupera Minhong Yan Lawrence H. Young Paul S. Oh Anne Eichmann
author_sort	Roxana Ola
title	PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia
title_short	PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia
title_full	PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia
title_fullStr	PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia
title_full_unstemmed	PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia
title_sort	pi3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/7b411bab54424730b576b6b6c001bd4f
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PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia

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