Functionally distinct and selectively phosphorylated GPCR subpopulations co-exist in a single cell

β2-adrenergic receptor (β2AR) can be phosphorylated by G protein receptor kinases and second messenger-dependent kinases. Here, the authors demonstrate that these phosphorylation events are specific to functionally distinct and spatially segregated subpopulations of β2AR that co-exist in a single ce...

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Autores principales:	Ao Shen, Madeline Nieves-Cintron, Yawen Deng, Qian Shi, Dhrubajyoti Chowdhury, Jinyi Qi, Johannes W. Hell, Manuel F. Navedo, Yang K. Xiang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7b42cd1c08694ec3afc892e537f6001c
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spelling	oai:doaj.org-article:7b42cd1c08694ec3afc892e537f6001c2021-12-02T14:40:31ZFunctionally distinct and selectively phosphorylated GPCR subpopulations co-exist in a single cell10.1038/s41467-018-03459-72041-1723https://doaj.org/article/7b42cd1c08694ec3afc892e537f6001c2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03459-7https://doaj.org/toc/2041-1723β2-adrenergic receptor (β2AR) can be phosphorylated by G protein receptor kinases and second messenger-dependent kinases. Here, the authors demonstrate that these phosphorylation events are specific to functionally distinct and spatially segregated subpopulations of β2AR that co-exist in a single cell.Ao ShenMadeline Nieves-CintronYawen DengQian ShiDhrubajyoti ChowdhuryJinyi QiJohannes W. HellManuel F. NavedoYang K. XiangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ao Shen Madeline Nieves-Cintron Yawen Deng Qian Shi Dhrubajyoti Chowdhury Jinyi Qi Johannes W. Hell Manuel F. Navedo Yang K. Xiang Functionally distinct and selectively phosphorylated GPCR subpopulations co-exist in a single cell
description	β2-adrenergic receptor (β2AR) can be phosphorylated by G protein receptor kinases and second messenger-dependent kinases. Here, the authors demonstrate that these phosphorylation events are specific to functionally distinct and spatially segregated subpopulations of β2AR that co-exist in a single cell.
format	article
author	Ao Shen Madeline Nieves-Cintron Yawen Deng Qian Shi Dhrubajyoti Chowdhury Jinyi Qi Johannes W. Hell Manuel F. Navedo Yang K. Xiang
author_facet	Ao Shen Madeline Nieves-Cintron Yawen Deng Qian Shi Dhrubajyoti Chowdhury Jinyi Qi Johannes W. Hell Manuel F. Navedo Yang K. Xiang
author_sort	Ao Shen
title	Functionally distinct and selectively phosphorylated GPCR subpopulations co-exist in a single cell
title_short	Functionally distinct and selectively phosphorylated GPCR subpopulations co-exist in a single cell
title_full	Functionally distinct and selectively phosphorylated GPCR subpopulations co-exist in a single cell
title_fullStr	Functionally distinct and selectively phosphorylated GPCR subpopulations co-exist in a single cell
title_full_unstemmed	Functionally distinct and selectively phosphorylated GPCR subpopulations co-exist in a single cell
title_sort	functionally distinct and selectively phosphorylated gpcr subpopulations co-exist in a single cell
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7b42cd1c08694ec3afc892e537f6001c
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Functionally distinct and selectively phosphorylated GPCR subpopulations co-exist in a single cell

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