ARSENIC INDUCED HISTOMORPHOLOGICAL ALGTERATIONS IN SIZE OF HEPATIC LOBULE AND AMELIORATIVE EFFECTS OF LAGENARIA SICERARIA

Objective: To study the effects of Lagenaria siceraria and arsenic on size of Hepatic lobule of Sprague Dawley rat. Study Design: Laboratory-based randomized controlled trial. Place and Duration of Study: Army Medical College, Rawalpindi, and National Institute of Health (NIH), Islamabad, for eight...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Saima Qureshi, Umbreen Noor, Ayesha Baqar, Khadija Qamar
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2019
Materias:	sprague dawley lagenaria siceraria Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7b45ba3929aa440994188ed2bec4e4ff
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7b45ba3929aa440994188ed2bec4e4ff
record_format	dspace
spelling	oai:doaj.org-article:7b45ba3929aa440994188ed2bec4e4ff2021-11-16T02:54:08ZARSENIC INDUCED HISTOMORPHOLOGICAL ALGTERATIONS IN SIZE OF HEPATIC LOBULE AND AMELIORATIVE EFFECTS OF LAGENARIA SICERARIA0030-96482411-8842https://doaj.org/article/7b45ba3929aa440994188ed2bec4e4ff2019-02-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/2500/2055https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To study the effects of Lagenaria siceraria and arsenic on size of Hepatic lobule of Sprague Dawley rat. Study Design: Laboratory-based randomized controlled trial. Place and Duration of Study: Army Medical College, Rawalpindi, and National Institute of Health (NIH), Islamabad, for eight weeks, from 20th Mar 2017 to 14th May 2017. Material and Methods: Fifty Sprague Dawley rats both male and female selected randomly and broadly allocated into five groups, each with 10 animals. Groups A and B animals were controls, C, D and E served as experimental groups. Sodium arsenite 5mg/kg body weight was initially given for a period of 4 weeks to the experimental groups C, D and E. After 4 weeks of therapy, the animals of groups A and C were sacrificed for histopathological study of liver to see the immediate effects of arsenic. Within the next 4 weeks group D animals were retained without any intervension. Group E animals were administered sodium arsenite (5mg/kg body weight) along with Lagenaria siceraria at a dose of 100mg/kg bodyweight. Group B served as a control for experimental group D and E. Animals of group B, D and E were sacrificed after last dose at the end these 4 weeks. Liver was removed and prepared for histological study. Size of hepatic lobule was studied. Data were analysed by SPSS V 22. A p-value 0.05 was considered statistically significant. Results: Moderate increase in the size of hepatic lobule was seen in group C as compared to control group A. Group.....Saima QureshiUmbreen NoorAyesha BaqarKhadija QamarArmy Medical College Rawalpindiarticlesprague dawleylagenaria sicerariaMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 69, Iss 1, Pp 76-82 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	sprague dawley lagenaria siceraria Medicine R Medicine (General) R5-920
spellingShingle	sprague dawley lagenaria siceraria Medicine R Medicine (General) R5-920 Saima Qureshi Umbreen Noor Ayesha Baqar Khadija Qamar ARSENIC INDUCED HISTOMORPHOLOGICAL ALGTERATIONS IN SIZE OF HEPATIC LOBULE AND AMELIORATIVE EFFECTS OF LAGENARIA SICERARIA
description	Objective: To study the effects of Lagenaria siceraria and arsenic on size of Hepatic lobule of Sprague Dawley rat. Study Design: Laboratory-based randomized controlled trial. Place and Duration of Study: Army Medical College, Rawalpindi, and National Institute of Health (NIH), Islamabad, for eight weeks, from 20th Mar 2017 to 14th May 2017. Material and Methods: Fifty Sprague Dawley rats both male and female selected randomly and broadly allocated into five groups, each with 10 animals. Groups A and B animals were controls, C, D and E served as experimental groups. Sodium arsenite 5mg/kg body weight was initially given for a period of 4 weeks to the experimental groups C, D and E. After 4 weeks of therapy, the animals of groups A and C were sacrificed for histopathological study of liver to see the immediate effects of arsenic. Within the next 4 weeks group D animals were retained without any intervension. Group E animals were administered sodium arsenite (5mg/kg body weight) along with Lagenaria siceraria at a dose of 100mg/kg bodyweight. Group B served as a control for experimental group D and E. Animals of group B, D and E were sacrificed after last dose at the end these 4 weeks. Liver was removed and prepared for histological study. Size of hepatic lobule was studied. Data were analysed by SPSS V 22. A p-value 0.05 was considered statistically significant. Results: Moderate increase in the size of hepatic lobule was seen in group C as compared to control group A. Group.....
format	article
author	Saima Qureshi Umbreen Noor Ayesha Baqar Khadija Qamar
author_facet	Saima Qureshi Umbreen Noor Ayesha Baqar Khadija Qamar
author_sort	Saima Qureshi
title	ARSENIC INDUCED HISTOMORPHOLOGICAL ALGTERATIONS IN SIZE OF HEPATIC LOBULE AND AMELIORATIVE EFFECTS OF LAGENARIA SICERARIA
title_short	ARSENIC INDUCED HISTOMORPHOLOGICAL ALGTERATIONS IN SIZE OF HEPATIC LOBULE AND AMELIORATIVE EFFECTS OF LAGENARIA SICERARIA
title_full	ARSENIC INDUCED HISTOMORPHOLOGICAL ALGTERATIONS IN SIZE OF HEPATIC LOBULE AND AMELIORATIVE EFFECTS OF LAGENARIA SICERARIA
title_fullStr	ARSENIC INDUCED HISTOMORPHOLOGICAL ALGTERATIONS IN SIZE OF HEPATIC LOBULE AND AMELIORATIVE EFFECTS OF LAGENARIA SICERARIA
title_full_unstemmed	ARSENIC INDUCED HISTOMORPHOLOGICAL ALGTERATIONS IN SIZE OF HEPATIC LOBULE AND AMELIORATIVE EFFECTS OF LAGENARIA SICERARIA
title_sort	arsenic induced histomorphological algterations in size of hepatic lobule and ameliorative effects of lagenaria siceraria
publisher	Army Medical College Rawalpindi
publishDate	2019
url	https://doaj.org/article/7b45ba3929aa440994188ed2bec4e4ff
work_keys_str_mv	AT saimaqureshi arsenicinducedhistomorphologicalalgterationsinsizeofhepaticlobuleandameliorativeeffectsoflagenariasiceraria AT umbreennoor arsenicinducedhistomorphologicalalgterationsinsizeofhepaticlobuleandameliorativeeffectsoflagenariasiceraria AT ayeshabaqar arsenicinducedhistomorphologicalalgterationsinsizeofhepaticlobuleandameliorativeeffectsoflagenariasiceraria AT khadijaqamar arsenicinducedhistomorphologicalalgterationsinsizeofhepaticlobuleandameliorativeeffectsoflagenariasiceraria
_version_	1718426794588110848

ARSENIC INDUCED HISTOMORPHOLOGICAL ALGTERATIONS IN SIZE OF HEPATIC LOBULE AND AMELIORATIVE EFFECTS OF LAGENARIA SICERARIA

Ejemplares similares