Imaging atherosclerosis in rheumatoid arthritis: evidence for increased prevalence, altered phenotype and a link between systemic and localised plaque inflammation

Imaging atherosclerosis in rheumatoid arthritis: evidence for increased prevalence, altered phenotype and a link between systemic and localised plaque inflammation

Abstract In rheumatoid arthritis (RA), chronic inflammation is thought to drive increased cardiovascular risk through accelerated atherosclerosis. It may also lead to a more high-risk plaque phenotype. We sought to investigate carotid plaque phenotype in RA patients using Dynamic Contrast-Enhanced M...

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Autores principales: S. Skeoch, P. L. Hubbard Cristinacce, H. Williams, P. Pemberton, D. Xu, J. Sun, J. James, C. Yuan, T. Hatsukami, P. D. Hockings, M. Y. Alexander, J. C. Waterton, I. N. Bruce
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Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/7b4667cb10d54c1c8e1088c2b63bb790
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spelling oai:doaj.org-article:7b4667cb10d54c1c8e1088c2b63bb7902021-12-02T16:07:46ZImaging atherosclerosis in rheumatoid arthritis: evidence for increased prevalence, altered phenotype and a link between systemic and localised plaque inflammation10.1038/s41598-017-00989-w2045-2322https://doaj.org/article/7b4667cb10d54c1c8e1088c2b63bb7902017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00989-whttps://doaj.org/toc/2045-2322Abstract In rheumatoid arthritis (RA), chronic inflammation is thought to drive increased cardiovascular risk through accelerated atherosclerosis. It may also lead to a more high-risk plaque phenotype. We sought to investigate carotid plaque phenotype in RA patients using Dynamic Contrast-Enhanced MRI (DCE-MRI) and Fludeoxyglucose Positron Emission Tomography(FDG-PET). In this pilot study, RA patients and age/sex-matched controls were evaluated for cardiovascular risk factors and carotid plaque on ultrasound. Subjects with plaque >2 mm thick underwent DCE-MRI, and a subgroup of patients had FDG-PET. Comparison of MRI findings between groups and correlation between clinical, serological markers and imaging findings was undertaken. 130 patients and 62 controls were recruited. Plaque was more prevalent in the RA group (53.1% vs 37.0%, p = 0.038) and was independently associated with IL6 levels (HR[95%CI]: 2.03 [1.26, 3.26] per quartile). DCE-MRI data were available in 15 patients and 5 controls. Higher prevalence of plaque calcification was noted in RA, despite similar plaque size (73.3% vs 20%, p = 0.04). FDG-PET detected plaque inflammation in 12/13 patients scanned and degree of inflammation correlated with hs-CRP (r = 0.58, p = 0.04). This study confirms increased prevalence of atherosclerosis in RA and provides data to support the hypothesis that patients have a high-risk plaque phenotype.S. SkeochP. L. Hubbard CristinacceH. WilliamsP. PembertonD. XuJ. SunJ. JamesC. YuanT. HatsukamiP. D. HockingsM. Y. AlexanderJ. C. WatertonI. N. BruceNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
S. Skeoch
P. L. Hubbard Cristinacce
H. Williams
P. Pemberton
D. Xu
J. Sun
J. James
C. Yuan
T. Hatsukami
P. D. Hockings
M. Y. Alexander
J. C. Waterton
I. N. Bruce
Imaging atherosclerosis in rheumatoid arthritis: evidence for increased prevalence, altered phenotype and a link between systemic and localised plaque inflammation
description Abstract In rheumatoid arthritis (RA), chronic inflammation is thought to drive increased cardiovascular risk through accelerated atherosclerosis. It may also lead to a more high-risk plaque phenotype. We sought to investigate carotid plaque phenotype in RA patients using Dynamic Contrast-Enhanced MRI (DCE-MRI) and Fludeoxyglucose Positron Emission Tomography(FDG-PET). In this pilot study, RA patients and age/sex-matched controls were evaluated for cardiovascular risk factors and carotid plaque on ultrasound. Subjects with plaque >2 mm thick underwent DCE-MRI, and a subgroup of patients had FDG-PET. Comparison of MRI findings between groups and correlation between clinical, serological markers and imaging findings was undertaken. 130 patients and 62 controls were recruited. Plaque was more prevalent in the RA group (53.1% vs 37.0%, p = 0.038) and was independently associated with IL6 levels (HR[95%CI]: 2.03 [1.26, 3.26] per quartile). DCE-MRI data were available in 15 patients and 5 controls. Higher prevalence of plaque calcification was noted in RA, despite similar plaque size (73.3% vs 20%, p = 0.04). FDG-PET detected plaque inflammation in 12/13 patients scanned and degree of inflammation correlated with hs-CRP (r = 0.58, p = 0.04). This study confirms increased prevalence of atherosclerosis in RA and provides data to support the hypothesis that patients have a high-risk plaque phenotype.
format article
author S. Skeoch
P. L. Hubbard Cristinacce
H. Williams
P. Pemberton
D. Xu
J. Sun
J. James
C. Yuan
T. Hatsukami
P. D. Hockings
M. Y. Alexander
J. C. Waterton
I. N. Bruce
author_facet S. Skeoch
P. L. Hubbard Cristinacce
H. Williams
P. Pemberton
D. Xu
J. Sun
J. James
C. Yuan
T. Hatsukami
P. D. Hockings
M. Y. Alexander
J. C. Waterton
I. N. Bruce
author_sort S. Skeoch
title Imaging atherosclerosis in rheumatoid arthritis: evidence for increased prevalence, altered phenotype and a link between systemic and localised plaque inflammation
title_short Imaging atherosclerosis in rheumatoid arthritis: evidence for increased prevalence, altered phenotype and a link between systemic and localised plaque inflammation
title_full Imaging atherosclerosis in rheumatoid arthritis: evidence for increased prevalence, altered phenotype and a link between systemic and localised plaque inflammation
title_fullStr Imaging atherosclerosis in rheumatoid arthritis: evidence for increased prevalence, altered phenotype and a link between systemic and localised plaque inflammation
title_full_unstemmed Imaging atherosclerosis in rheumatoid arthritis: evidence for increased prevalence, altered phenotype and a link between systemic and localised plaque inflammation
title_sort imaging atherosclerosis in rheumatoid arthritis: evidence for increased prevalence, altered phenotype and a link between systemic and localised plaque inflammation
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/7b4667cb10d54c1c8e1088c2b63bb790
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