Interaction Between Commensal Bacteria, Immune Response and the Intestinal Barrier in Inflammatory Bowel Disease

In inflammatory bowel disease (IBD), intestinal mucosa cell and intestinal epithelial cell are severely damaged, and then their susceptibility to bacteria increases, so many commensal bacteria become pathogenic. The pathogenic commensal bacteria can stimulate a series of compensatory immune response...

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Autores principales:	Yongyan Chen, Wenwen Cui, Xiao Li, Huan Yang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	commensal bacteria immune response intestinal barrier IBD SCFAs Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/7b480a1791b34a56b71f433a5a8a745d
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id	oai:doaj.org-article:7b480a1791b34a56b71f433a5a8a745d
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spelling	oai:doaj.org-article:7b480a1791b34a56b71f433a5a8a745d2021-11-11T08:25:52ZInteraction Between Commensal Bacteria, Immune Response and the Intestinal Barrier in Inflammatory Bowel Disease1664-322410.3389/fimmu.2021.761981https://doaj.org/article/7b480a1791b34a56b71f433a5a8a745d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.761981/fullhttps://doaj.org/toc/1664-3224In inflammatory bowel disease (IBD), intestinal mucosa cell and intestinal epithelial cell are severely damaged, and then their susceptibility to bacteria increases, so many commensal bacteria become pathogenic. The pathogenic commensal bacteria can stimulate a series of compensatory immune responses in the intestine. However, the immune response prevents the intestinal tract from restoring homeostasis, which in turn produces an indispensable inflammatory response. On the contrary, in IBD, the fierce inflammatory response contributes to the development of IBD. However, the effect of commensal bacteria on inflammation in IBD has not been clearly studied. Therefore, we further summarize the changes brought about by the changes of commensal bacteria to the inflammation of the intestines and their mutual influence. This article reviews the protective mechanism of commensal bacteria in healthy people and the mechanism of commensal bacteria and immune response to the destruction of the intestinal barrier when IBD occurs. The treatment and prevention of IBD are also briefly summarized.Yongyan ChenWenwen CuiXiao LiHuan YangFrontiers Media S.A.articlecommensal bacteriaimmune responseintestinal barrierIBDSCFAsImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	commensal bacteria immune response intestinal barrier IBD SCFAs Immunologic diseases. Allergy RC581-607
spellingShingle	commensal bacteria immune response intestinal barrier IBD SCFAs Immunologic diseases. Allergy RC581-607 Yongyan Chen Wenwen Cui Xiao Li Huan Yang Interaction Between Commensal Bacteria, Immune Response and the Intestinal Barrier in Inflammatory Bowel Disease
description	In inflammatory bowel disease (IBD), intestinal mucosa cell and intestinal epithelial cell are severely damaged, and then their susceptibility to bacteria increases, so many commensal bacteria become pathogenic. The pathogenic commensal bacteria can stimulate a series of compensatory immune responses in the intestine. However, the immune response prevents the intestinal tract from restoring homeostasis, which in turn produces an indispensable inflammatory response. On the contrary, in IBD, the fierce inflammatory response contributes to the development of IBD. However, the effect of commensal bacteria on inflammation in IBD has not been clearly studied. Therefore, we further summarize the changes brought about by the changes of commensal bacteria to the inflammation of the intestines and their mutual influence. This article reviews the protective mechanism of commensal bacteria in healthy people and the mechanism of commensal bacteria and immune response to the destruction of the intestinal barrier when IBD occurs. The treatment and prevention of IBD are also briefly summarized.
format	article
author	Yongyan Chen Wenwen Cui Xiao Li Huan Yang
author_facet	Yongyan Chen Wenwen Cui Xiao Li Huan Yang
author_sort	Yongyan Chen
title	Interaction Between Commensal Bacteria, Immune Response and the Intestinal Barrier in Inflammatory Bowel Disease
title_short	Interaction Between Commensal Bacteria, Immune Response and the Intestinal Barrier in Inflammatory Bowel Disease
title_full	Interaction Between Commensal Bacteria, Immune Response and the Intestinal Barrier in Inflammatory Bowel Disease
title_fullStr	Interaction Between Commensal Bacteria, Immune Response and the Intestinal Barrier in Inflammatory Bowel Disease
title_full_unstemmed	Interaction Between Commensal Bacteria, Immune Response and the Intestinal Barrier in Inflammatory Bowel Disease
title_sort	interaction between commensal bacteria, immune response and the intestinal barrier in inflammatory bowel disease
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/7b480a1791b34a56b71f433a5a8a745d
work_keys_str_mv	AT yongyanchen interactionbetweencommensalbacteriaimmuneresponseandtheintestinalbarrierininflammatoryboweldisease AT wenwencui interactionbetweencommensalbacteriaimmuneresponseandtheintestinalbarrierininflammatoryboweldisease AT xiaoli interactionbetweencommensalbacteriaimmuneresponseandtheintestinalbarrierininflammatoryboweldisease AT huanyang interactionbetweencommensalbacteriaimmuneresponseandtheintestinalbarrierininflammatoryboweldisease
_version_	1718439319922802688

Interaction Between Commensal Bacteria, Immune Response and the Intestinal Barrier in Inflammatory Bowel Disease

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