Higher Serum Asprosin Level is Associated with Urinary Albumin Excretion and Renal Function in Type 2 Diabetes

Higher Serum Asprosin Level is Associated with Urinary Albumin Excretion and Renal Function in Type 2 Diabetes

Xia Deng, Li Zhao, Chang Guo, Ling Yang, Dong Wang, Yanyan Li, Hong Xia, Chenxi Wang, Zhensheng Cai, Lian Li, Zhicong Zhao, Guoyue Yuan Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, People’s Republic of ChinaCorrespondence: Guoyue Yuan;...

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Autores principales: Deng X, Zhao L, Guo C, Yang L, Wang D, Li Y, Xia H, Wang C, Cai Z, Li L, Zhao Z, Yuan G
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2020
Materias:
asprosin
type 2 diabetes mellitus
diabetic nephropathy
Specialties of internal medicine
RC581-951
Acceso en línea:https://doaj.org/article/7b4a0de4a96b46aeb048de5b78c74bc3
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spelling oai:doaj.org-article:7b4a0de4a96b46aeb048de5b78c74bc32021-12-02T13:13:04ZHigher Serum Asprosin Level is Associated with Urinary Albumin Excretion and Renal Function in Type 2 Diabetes1178-7007https://doaj.org/article/7b4a0de4a96b46aeb048de5b78c74bc32020-11-01T00:00:00Zhttps://www.dovepress.com/higher-serum-asprosin-level-is-associated-with-urinary-albumin-excreti-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Xia Deng, Li Zhao, Chang Guo, Ling Yang, Dong Wang, Yanyan Li, Hong Xia, Chenxi Wang, Zhensheng Cai, Lian Li, Zhicong Zhao, Guoyue Yuan Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, People’s Republic of ChinaCorrespondence: Guoyue Yuan; Zhicong ZhaoDepartment of Endocrinology, Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Zhenjiang, Jiangsu 212001, People’s Republic of ChinaTel +86-13505289352; +86-18752965615Email yuanguoyue@ujs.edu.cn; 2211517025@stmail.ujs.edu.cnAim: We detected whether serum asprosin levels play a role in the occurrence and development of albuminuria in patients with type 2 diabetes mellitus (T2DM), which has not been previously discussed.Methods: Based on urinary albumin/creatinine ratio (UACR), 207 T2DM patients were divided into T2DM patients with normoalbuminuria (UACR< 30 mg/g), microalbuminuria (30≤UACR< 300 mg/g), and macroalbuminuria (UACR≥ 300 mg/g). Serum asprosin levels were determined by enzyme-linked immunosorbent assay.Results: Comparatively, the serum asprosin levels in T2DM patient groups with macroalbuminuria [2.37 (1.63– 3.57)] and microalbuminuria [2.10 (1.60– 2.90)] were significantly increased than the normoalbuminuria group [1.59 (1.18– 2.09)] (P< 0.001). Importantly, the serum level of asprosin was positively correlated with UACR (r=0.304, P< 0.001), creatinine (r=0.157, P=0.024), blood urea nitrogen (BUN) (r=0.244, P< 0.001), and negatively with glomerular filtration rate (eGFR) (r=− 0.159, P=0.022). Furthermore, multiple stepwise regression analyses showed that asprosin was significantly and independently related to UACR, BUN, DBP, and LDL-C (P< 0.05). Besides, after adjustment for the confounders, the serum asprosin level was constantly and independently associated with the development of albuminuria in T2DM patients [OR (95% CI): 2.003 (1.37∼ 2.928), P < 0.001].Conclusion: Obviously, the serum asprosin level was independently correlated with UACR in T2DM patients, which implies circulating asprosin may play an essential role in the pathogenesis of diabetic nephropathy.Keywords: asprosin, type 2 diabetes mellitus, diabetic nephropathyDeng XZhao LGuo CYang LWang DLi YXia HWang CCai ZLi LZhao ZYuan GDove Medical Pressarticleasprosintype 2 diabetes mellitusdiabetic nephropathySpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 4341-4351 (2020)
institution DOAJ
collection DOAJ
language EN
topic asprosin
type 2 diabetes mellitus
diabetic nephropathy
Specialties of internal medicine
RC581-951
spellingShingle asprosin
type 2 diabetes mellitus
diabetic nephropathy
Specialties of internal medicine
RC581-951
Deng X
Zhao L
Guo C
Yang L
Wang D
Li Y
Xia H
Wang C
Cai Z
Li L
Zhao Z
Yuan G
Higher Serum Asprosin Level is Associated with Urinary Albumin Excretion and Renal Function in Type 2 Diabetes
description Xia Deng, Li Zhao, Chang Guo, Ling Yang, Dong Wang, Yanyan Li, Hong Xia, Chenxi Wang, Zhensheng Cai, Lian Li, Zhicong Zhao, Guoyue Yuan Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, People’s Republic of ChinaCorrespondence: Guoyue Yuan; Zhicong ZhaoDepartment of Endocrinology, Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Zhenjiang, Jiangsu 212001, People’s Republic of ChinaTel +86-13505289352; +86-18752965615Email yuanguoyue@ujs.edu.cn; 2211517025@stmail.ujs.edu.cnAim: We detected whether serum asprosin levels play a role in the occurrence and development of albuminuria in patients with type 2 diabetes mellitus (T2DM), which has not been previously discussed.Methods: Based on urinary albumin/creatinine ratio (UACR), 207 T2DM patients were divided into T2DM patients with normoalbuminuria (UACR< 30 mg/g), microalbuminuria (30≤UACR< 300 mg/g), and macroalbuminuria (UACR≥ 300 mg/g). Serum asprosin levels were determined by enzyme-linked immunosorbent assay.Results: Comparatively, the serum asprosin levels in T2DM patient groups with macroalbuminuria [2.37 (1.63– 3.57)] and microalbuminuria [2.10 (1.60– 2.90)] were significantly increased than the normoalbuminuria group [1.59 (1.18– 2.09)] (P< 0.001). Importantly, the serum level of asprosin was positively correlated with UACR (r=0.304, P< 0.001), creatinine (r=0.157, P=0.024), blood urea nitrogen (BUN) (r=0.244, P< 0.001), and negatively with glomerular filtration rate (eGFR) (r=− 0.159, P=0.022). Furthermore, multiple stepwise regression analyses showed that asprosin was significantly and independently related to UACR, BUN, DBP, and LDL-C (P< 0.05). Besides, after adjustment for the confounders, the serum asprosin level was constantly and independently associated with the development of albuminuria in T2DM patients [OR (95% CI): 2.003 (1.37∼ 2.928), P < 0.001].Conclusion: Obviously, the serum asprosin level was independently correlated with UACR in T2DM patients, which implies circulating asprosin may play an essential role in the pathogenesis of diabetic nephropathy.Keywords: asprosin, type 2 diabetes mellitus, diabetic nephropathy
format article
author Deng X
Zhao L
Guo C
Yang L
Wang D
Li Y
Xia H
Wang C
Cai Z
Li L
Zhao Z
Yuan G
author_facet Deng X
Zhao L
Guo C
Yang L
Wang D
Li Y
Xia H
Wang C
Cai Z
Li L
Zhao Z
Yuan G
author_sort Deng X
title Higher Serum Asprosin Level is Associated with Urinary Albumin Excretion and Renal Function in Type 2 Diabetes
title_short Higher Serum Asprosin Level is Associated with Urinary Albumin Excretion and Renal Function in Type 2 Diabetes
title_full Higher Serum Asprosin Level is Associated with Urinary Albumin Excretion and Renal Function in Type 2 Diabetes
title_fullStr Higher Serum Asprosin Level is Associated with Urinary Albumin Excretion and Renal Function in Type 2 Diabetes
title_full_unstemmed Higher Serum Asprosin Level is Associated with Urinary Albumin Excretion and Renal Function in Type 2 Diabetes
title_sort higher serum asprosin level is associated with urinary albumin excretion and renal function in type 2 diabetes
publisher Dove Medical Press
publishDate 2020
url https://doaj.org/article/7b4a0de4a96b46aeb048de5b78c74bc3
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