CAPS1 is involved in hippocampal synaptic plasticity and hippocampus-associated learning

Abstract Calcium-dependent activator protein for secretion 1 (CAPS1) is a key molecule in vesicular exocytosis, probably in the priming step. However, CAPS1’s role in synaptic plasticity and brain function is elusive. Herein, we showed that synaptic plasticity and learning behavior were impaired in...

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Autores principales:	Chiaki Ishii, Natsumi Shibano, Mio Yamazaki, Tomoki Arima, Yuna Kato, Yuki Ishii, Yo Shinoda, Yugo Fukazawa, Tetsushi Sadakata, Yoshitake Sano, Teiichi Furuichi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7b4a4e0d50c044eb8032334abbcbf217
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spelling	oai:doaj.org-article:7b4a4e0d50c044eb8032334abbcbf2172021-12-02T18:27:47ZCAPS1 is involved in hippocampal synaptic plasticity and hippocampus-associated learning10.1038/s41598-021-88009-w2045-2322https://doaj.org/article/7b4a4e0d50c044eb8032334abbcbf2172021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88009-whttps://doaj.org/toc/2045-2322Abstract Calcium-dependent activator protein for secretion 1 (CAPS1) is a key molecule in vesicular exocytosis, probably in the priming step. However, CAPS1’s role in synaptic plasticity and brain function is elusive. Herein, we showed that synaptic plasticity and learning behavior were impaired in forebrain and/or hippocampus-specific Caps1 conditional knockout (cKO) mice by means of molecular, physiological, and behavioral analyses. Neonatal Caps1 cKO mice showed a decrease in the number of docked vesicles in the hippocampal CA3 region, with no detectable changes in the distribution of other major exocytosis-related molecules. Additionally, long-term potentiation (LTP) was partially and severely impaired in the CA1 and CA3 regions, respectively. CA1 LTP was reinforced by repeated high-frequency stimuli, whereas CA3 LTP was completely abolished. Accordingly, hippocampus-associated learning was severely impaired in adeno-associated virus (AAV) infection-mediated postnatal Caps1 cKO mice. Collectively, our findings suggest that CAPS1 is a key protein involved in the cellular mechanisms underlying hippocampal synaptic release and plasticity, which is crucial for hippocampus-associated learning.Chiaki IshiiNatsumi ShibanoMio YamazakiTomoki ArimaYuna KatoYuki IshiiYo ShinodaYugo FukazawaTetsushi SadakataYoshitake SanoTeiichi FuruichiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chiaki Ishii Natsumi Shibano Mio Yamazaki Tomoki Arima Yuna Kato Yuki Ishii Yo Shinoda Yugo Fukazawa Tetsushi Sadakata Yoshitake Sano Teiichi Furuichi CAPS1 is involved in hippocampal synaptic plasticity and hippocampus-associated learning
description	Abstract Calcium-dependent activator protein for secretion 1 (CAPS1) is a key molecule in vesicular exocytosis, probably in the priming step. However, CAPS1’s role in synaptic plasticity and brain function is elusive. Herein, we showed that synaptic plasticity and learning behavior were impaired in forebrain and/or hippocampus-specific Caps1 conditional knockout (cKO) mice by means of molecular, physiological, and behavioral analyses. Neonatal Caps1 cKO mice showed a decrease in the number of docked vesicles in the hippocampal CA3 region, with no detectable changes in the distribution of other major exocytosis-related molecules. Additionally, long-term potentiation (LTP) was partially and severely impaired in the CA1 and CA3 regions, respectively. CA1 LTP was reinforced by repeated high-frequency stimuli, whereas CA3 LTP was completely abolished. Accordingly, hippocampus-associated learning was severely impaired in adeno-associated virus (AAV) infection-mediated postnatal Caps1 cKO mice. Collectively, our findings suggest that CAPS1 is a key protein involved in the cellular mechanisms underlying hippocampal synaptic release and plasticity, which is crucial for hippocampus-associated learning.
format	article
author	Chiaki Ishii Natsumi Shibano Mio Yamazaki Tomoki Arima Yuna Kato Yuki Ishii Yo Shinoda Yugo Fukazawa Tetsushi Sadakata Yoshitake Sano Teiichi Furuichi
author_facet	Chiaki Ishii Natsumi Shibano Mio Yamazaki Tomoki Arima Yuna Kato Yuki Ishii Yo Shinoda Yugo Fukazawa Tetsushi Sadakata Yoshitake Sano Teiichi Furuichi
author_sort	Chiaki Ishii
title	CAPS1 is involved in hippocampal synaptic plasticity and hippocampus-associated learning
title_short	CAPS1 is involved in hippocampal synaptic plasticity and hippocampus-associated learning
title_full	CAPS1 is involved in hippocampal synaptic plasticity and hippocampus-associated learning
title_fullStr	CAPS1 is involved in hippocampal synaptic plasticity and hippocampus-associated learning
title_full_unstemmed	CAPS1 is involved in hippocampal synaptic plasticity and hippocampus-associated learning
title_sort	caps1 is involved in hippocampal synaptic plasticity and hippocampus-associated learning
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7b4a4e0d50c044eb8032334abbcbf217
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CAPS1 is involved in hippocampal synaptic plasticity and hippocampus-associated learning

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