Roles for DNA polymerase δ in initiating and terminating leading strand DNA replication

DNA polymerases epsilon and delta, respectively, perform the majority of leading and lagging strand replication of the eukaryotic nuclear genome. Here the authors map the ribonucleotide fingerprints of the polymerases to show the special roles of polymerase delta on both strands during replication i...

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Autores principales: Zhi-Xiong Zhou, Scott A. Lujan, Adam B. Burkholder, Marta A. Garbacz, Thomas A. Kunkel
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/7b4b72b62f4042e1ae134de4b46a5866
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Sumario:DNA polymerases epsilon and delta, respectively, perform the majority of leading and lagging strand replication of the eukaryotic nuclear genome. Here the authors map the ribonucleotide fingerprints of the polymerases to show the special roles of polymerase delta on both strands during replication initiation and termination.