Alterations in the gut bacterial microbiome in people with type 2 diabetes mellitus and diabetic retinopathy

Abstract Gut bacterial microbiome dysbiosis in type 2 Diabetes Mellitus (T2DM) has been reported, but such an association with Diabetic Retinopathy (DR) is not known. We explored possible link between gut bacterial microbiome dysbiosis and DR. Using fecal samples of healthy controls (HC) and people...

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Autores principales:	Taraprasad Das, Rajagopalaboopathi Jayasudha, SamaKalyana Chakravarthy, Gumpili Sai Prashanthi, Archana Bhargava, Mudit Tyagi, Padmaja Kumari Rani, Rajeev Reddy Pappuru, Savitri Sharma, Sisinthy Shivaji
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7b4bd49f63cf488a9e21f2fc16ff870d
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spelling	oai:doaj.org-article:7b4bd49f63cf488a9e21f2fc16ff870d2021-12-02T10:44:08ZAlterations in the gut bacterial microbiome in people with type 2 diabetes mellitus and diabetic retinopathy10.1038/s41598-021-82538-02045-2322https://doaj.org/article/7b4bd49f63cf488a9e21f2fc16ff870d2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82538-0https://doaj.org/toc/2045-2322Abstract Gut bacterial microbiome dysbiosis in type 2 Diabetes Mellitus (T2DM) has been reported, but such an association with Diabetic Retinopathy (DR) is not known. We explored possible link between gut bacterial microbiome dysbiosis and DR. Using fecal samples of healthy controls (HC) and people with T2DM with/without DR, gut bacterial communities were analysed using 16S rRNA gene sequencing and data analysed using QIIME and R software. Dysbiosis in the gut microbiomes, at phyla and genera level, was observed in people with T2DM and DR compared to HC. People with DR exhibited greater discrimination from HC. Microbiomes of people with T2DM and DR were also significantly different. Both DM and DR microbiomes showed a decrease in anti-inflammatory, probiotic and other bacteria that could be pathogenic, compared to HC, and the observed change was more pronounced in people with DR. This is the first report demonstrating dysbiosis in the gut microbiome (alteration in the diversity and abundance at the phyla and genera level) in people with DR compared to HC. Such studies would help in developing novel and targeted therapies to improve treatment of DR.Taraprasad DasRajagopalaboopathi JayasudhaSamaKalyana ChakravarthyGumpili Sai PrashanthiArchana BhargavaMudit TyagiPadmaja Kumari RaniRajeev Reddy PappuruSavitri SharmaSisinthy ShivajiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Taraprasad Das Rajagopalaboopathi Jayasudha SamaKalyana Chakravarthy Gumpili Sai Prashanthi Archana Bhargava Mudit Tyagi Padmaja Kumari Rani Rajeev Reddy Pappuru Savitri Sharma Sisinthy Shivaji Alterations in the gut bacterial microbiome in people with type 2 diabetes mellitus and diabetic retinopathy
description	Abstract Gut bacterial microbiome dysbiosis in type 2 Diabetes Mellitus (T2DM) has been reported, but such an association with Diabetic Retinopathy (DR) is not known. We explored possible link between gut bacterial microbiome dysbiosis and DR. Using fecal samples of healthy controls (HC) and people with T2DM with/without DR, gut bacterial communities were analysed using 16S rRNA gene sequencing and data analysed using QIIME and R software. Dysbiosis in the gut microbiomes, at phyla and genera level, was observed in people with T2DM and DR compared to HC. People with DR exhibited greater discrimination from HC. Microbiomes of people with T2DM and DR were also significantly different. Both DM and DR microbiomes showed a decrease in anti-inflammatory, probiotic and other bacteria that could be pathogenic, compared to HC, and the observed change was more pronounced in people with DR. This is the first report demonstrating dysbiosis in the gut microbiome (alteration in the diversity and abundance at the phyla and genera level) in people with DR compared to HC. Such studies would help in developing novel and targeted therapies to improve treatment of DR.
format	article
author	Taraprasad Das Rajagopalaboopathi Jayasudha SamaKalyana Chakravarthy Gumpili Sai Prashanthi Archana Bhargava Mudit Tyagi Padmaja Kumari Rani Rajeev Reddy Pappuru Savitri Sharma Sisinthy Shivaji
author_facet	Taraprasad Das Rajagopalaboopathi Jayasudha SamaKalyana Chakravarthy Gumpili Sai Prashanthi Archana Bhargava Mudit Tyagi Padmaja Kumari Rani Rajeev Reddy Pappuru Savitri Sharma Sisinthy Shivaji
author_sort	Taraprasad Das
title	Alterations in the gut bacterial microbiome in people with type 2 diabetes mellitus and diabetic retinopathy
title_short	Alterations in the gut bacterial microbiome in people with type 2 diabetes mellitus and diabetic retinopathy
title_full	Alterations in the gut bacterial microbiome in people with type 2 diabetes mellitus and diabetic retinopathy
title_fullStr	Alterations in the gut bacterial microbiome in people with type 2 diabetes mellitus and diabetic retinopathy
title_full_unstemmed	Alterations in the gut bacterial microbiome in people with type 2 diabetes mellitus and diabetic retinopathy
title_sort	alterations in the gut bacterial microbiome in people with type 2 diabetes mellitus and diabetic retinopathy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7b4bd49f63cf488a9e21f2fc16ff870d
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Alterations in the gut bacterial microbiome in people with type 2 diabetes mellitus and diabetic retinopathy

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