Role of leptin resistance in the development of obesity in older patients

Sophie Carter,1,* Alexandre Caron,2,* Denis Richard,2 Frédéric Picard1 1Faculty of Pharmacy, 2Faculty of Medicine, Dept Anatomy and Physiology, Université Laval, Québec, QC, Canada *These authors contributed equally to the work Abstract: Obesity is a glo...

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Autores principales:	Carter S, Caron A, Richard D, Picard F
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Leptin obesity aging insulin sensitivity brown adipose tissue Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/7b4dcc499df648c19dac83f96c85cea8
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spelling	oai:doaj.org-article:7b4dcc499df648c19dac83f96c85cea82021-12-02T08:52:00ZRole of leptin resistance in the development of obesity in older patients1178-1998https://doaj.org/article/7b4dcc499df648c19dac83f96c85cea82013-07-01T00:00:00Zhttps://www.dovepress.com/role-of-leptin-resistance-in-the-development-of-obesity-in-older-patie-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Sophie Carter,1,* Alexandre Caron,2,* Denis Richard,2 Frédéric Picard1 1Faculty of Pharmacy, 2Faculty of Medicine, Dept Anatomy and Physiology, Université Laval, Québec, QC, Canada *These authors contributed equally to the work Abstract: Obesity is a global epidemic associated with aging-like cellular processes; in both aging and obesity, resistance to hormones such as insulin and leptin can be observed. Leptin is a circulating hormone/cytokine with central and peripheral effects that is released mainly by subcutaneous white adipose tissue. Centrally, leptin controls food intake, energy expenditure, and fat distribution, whereas it controls (among several others) insulin sensitivity, free fatty acids (FFAs) oxidation, and lipolysis in the periphery. Aging is associated with important changes in both the distribution and the composition of adipose tissue. Fat is redistributed from the subcutaneous to the visceral depot and increased inflammation participates in adipocyte dysfunction. This redistribution of adipose tissue in favor of visceral fat influences negatively both longevity and healthy aging as shown in numerous animal models. These modifications observed during aging are also associated with leptin resistance. This resistance blunts normal central and peripheral functions of leptin, which leads to a decrease in neuroendocrine function and insulin sensitivity, an imbalance in energy regulation, and disturbances in lipid metabolism. Here, we review how age-related leptin resistance triggers metabolic disturbances and affects the longevity of obese patients. Furthermore, we discuss the potential impacts of leptin resistance on the decline of brown adipose tissue thermogenesis observed in elderly individuals. Keywords: leptin, obesity, aging, insulin sensitivity, brown adipose tissueCarter SCaron ARichard DPicard FDove Medical PressarticleLeptinobesityaginginsulin sensitivitybrown adipose tissueGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 8, Pp 829-844 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Leptin obesity aging insulin sensitivity brown adipose tissue Geriatrics RC952-954.6
spellingShingle	Leptin obesity aging insulin sensitivity brown adipose tissue Geriatrics RC952-954.6 Carter S Caron A Richard D Picard F Role of leptin resistance in the development of obesity in older patients
description	Sophie Carter,1,* Alexandre Caron,2,* Denis Richard,2 Frédéric Picard1 1Faculty of Pharmacy, 2Faculty of Medicine, Dept Anatomy and Physiology, Université Laval, Québec, QC, Canada *These authors contributed equally to the work Abstract: Obesity is a global epidemic associated with aging-like cellular processes; in both aging and obesity, resistance to hormones such as insulin and leptin can be observed. Leptin is a circulating hormone/cytokine with central and peripheral effects that is released mainly by subcutaneous white adipose tissue. Centrally, leptin controls food intake, energy expenditure, and fat distribution, whereas it controls (among several others) insulin sensitivity, free fatty acids (FFAs) oxidation, and lipolysis in the periphery. Aging is associated with important changes in both the distribution and the composition of adipose tissue. Fat is redistributed from the subcutaneous to the visceral depot and increased inflammation participates in adipocyte dysfunction. This redistribution of adipose tissue in favor of visceral fat influences negatively both longevity and healthy aging as shown in numerous animal models. These modifications observed during aging are also associated with leptin resistance. This resistance blunts normal central and peripheral functions of leptin, which leads to a decrease in neuroendocrine function and insulin sensitivity, an imbalance in energy regulation, and disturbances in lipid metabolism. Here, we review how age-related leptin resistance triggers metabolic disturbances and affects the longevity of obese patients. Furthermore, we discuss the potential impacts of leptin resistance on the decline of brown adipose tissue thermogenesis observed in elderly individuals. Keywords: leptin, obesity, aging, insulin sensitivity, brown adipose tissue
format	article
author	Carter S Caron A Richard D Picard F
author_facet	Carter S Caron A Richard D Picard F
author_sort	Carter S
title	Role of leptin resistance in the development of obesity in older patients
title_short	Role of leptin resistance in the development of obesity in older patients
title_full	Role of leptin resistance in the development of obesity in older patients
title_fullStr	Role of leptin resistance in the development of obesity in older patients
title_full_unstemmed	Role of leptin resistance in the development of obesity in older patients
title_sort	role of leptin resistance in the development of obesity in older patients
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/7b4dcc499df648c19dac83f96c85cea8
work_keys_str_mv	AT carters roleofleptinresistanceinthedevelopmentofobesityinolderpatients AT carona roleofleptinresistanceinthedevelopmentofobesityinolderpatients AT richardd roleofleptinresistanceinthedevelopmentofobesityinolderpatients AT picardf roleofleptinresistanceinthedevelopmentofobesityinolderpatients
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Role of leptin resistance in the development of obesity in older patients

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