Correlation between CD44+ cancer stem cell expression and histopathological types of nasopharyngeal carcinoma [version 2; peer review: 2 approved]

Background: Nasopharyngeal carcinoma (NPC) recurrency rate is still high despite patients receiving complete treatment. The response to treatment may vary depending on the type of histopathology and Epstein-Barr virus, however the mechanism remains unclear. Recent studies have found that there is a...

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Autores principales:	Muhtarum Yusuf, Indriyadevi Indra, Sri Herawati Juniati, Yussy Afriani Dewi
Formato:	article
Lenguaje:	EN
Publicado:	F1000 Research Ltd 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7b516e7338ed4c63bb252cb60ab149af
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spelling	oai:doaj.org-article:7b516e7338ed4c63bb252cb60ab149af2021-11-15T15:26:10ZCorrelation between CD44+ cancer stem cell expression and histopathological types of nasopharyngeal carcinoma [version 2; peer review: 2 approved]2046-140210.12688/f1000research.53643.2https://doaj.org/article/7b516e7338ed4c63bb252cb60ab149af2021-11-01T00:00:00Zhttps://f1000research.com/articles/10-678/v2https://doaj.org/toc/2046-1402Background: Nasopharyngeal carcinoma (NPC) recurrency rate is still high despite patients receiving complete treatment. The response to treatment may vary depending on the type of histopathology and Epstein-Barr virus, however the mechanism remains unclear. Recent studies have found that there is a relationship between response to treatment and the presence of cancer stem cells (CSCs). CD44+ cancer stem cells may cause cancer cells to be resistant to treatment. Therefore, this cross-sectional study aims to determine the correlation between CD44 + cancer stem cell expression and the histopathological types of NPC. Method: Samples were obtained from NPC biopsies of type I, II, III patients (based on WHO histopathology criteria), who had not received prior treatment. CD44+ expression was examined using immunohistochemistry methods by staining CD44+ monoclonal antibodies. The degree of CD44+ cell membrane expression was based on the immunoreactive score scale or the Remmele index scale. Results: Most histopathological types were WHO type III (21 patients, 50%), followed by type II (18 patients, 42.86%), and type I (3 patients, 7.14%). CD44 + expression on type I showed one patient had moderate positive and two patients had a high-positive expression. In type II, 10 were moderate positive and eight were high-positive. In type III, one patient was low-positive, 11 were moderate positive and nine patients were high-positive. Statistical analysis showed that the CD44+ expression difference between the three histopathology types were not statistically significant. Conclusion: There were no correlations between CD44 + expression and histopathological type of NPC.Muhtarum YusufIndriyadevi IndraSri Herawati JuniatiYussy Afriani DewiF1000 Research LtdarticleMedicineRScienceQENF1000Research, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Muhtarum Yusuf Indriyadevi Indra Sri Herawati Juniati Yussy Afriani Dewi Correlation between CD44+ cancer stem cell expression and histopathological types of nasopharyngeal carcinoma [version 2; peer review: 2 approved]
description	Background: Nasopharyngeal carcinoma (NPC) recurrency rate is still high despite patients receiving complete treatment. The response to treatment may vary depending on the type of histopathology and Epstein-Barr virus, however the mechanism remains unclear. Recent studies have found that there is a relationship between response to treatment and the presence of cancer stem cells (CSCs). CD44+ cancer stem cells may cause cancer cells to be resistant to treatment. Therefore, this cross-sectional study aims to determine the correlation between CD44 + cancer stem cell expression and the histopathological types of NPC. Method: Samples were obtained from NPC biopsies of type I, II, III patients (based on WHO histopathology criteria), who had not received prior treatment. CD44+ expression was examined using immunohistochemistry methods by staining CD44+ monoclonal antibodies. The degree of CD44+ cell membrane expression was based on the immunoreactive score scale or the Remmele index scale. Results: Most histopathological types were WHO type III (21 patients, 50%), followed by type II (18 patients, 42.86%), and type I (3 patients, 7.14%). CD44 + expression on type I showed one patient had moderate positive and two patients had a high-positive expression. In type II, 10 were moderate positive and eight were high-positive. In type III, one patient was low-positive, 11 were moderate positive and nine patients were high-positive. Statistical analysis showed that the CD44+ expression difference between the three histopathology types were not statistically significant. Conclusion: There were no correlations between CD44 + expression and histopathological type of NPC.
format	article
author	Muhtarum Yusuf Indriyadevi Indra Sri Herawati Juniati Yussy Afriani Dewi
author_facet	Muhtarum Yusuf Indriyadevi Indra Sri Herawati Juniati Yussy Afriani Dewi
author_sort	Muhtarum Yusuf
title	Correlation between CD44+ cancer stem cell expression and histopathological types of nasopharyngeal carcinoma [version 2; peer review: 2 approved]
title_short	Correlation between CD44+ cancer stem cell expression and histopathological types of nasopharyngeal carcinoma [version 2; peer review: 2 approved]
title_full	Correlation between CD44+ cancer stem cell expression and histopathological types of nasopharyngeal carcinoma [version 2; peer review: 2 approved]
title_fullStr	Correlation between CD44+ cancer stem cell expression and histopathological types of nasopharyngeal carcinoma [version 2; peer review: 2 approved]
title_full_unstemmed	Correlation between CD44+ cancer stem cell expression and histopathological types of nasopharyngeal carcinoma [version 2; peer review: 2 approved]
title_sort	correlation between cd44+ cancer stem cell expression and histopathological types of nasopharyngeal carcinoma [version 2; peer review: 2 approved]
publisher	F1000 Research Ltd
publishDate	2021
url	https://doaj.org/article/7b516e7338ed4c63bb252cb60ab149af
work_keys_str_mv	AT muhtarumyusuf correlationbetweencd44cancerstemcellexpressionandhistopathologicaltypesofnasopharyngealcarcinomaversion2peerreview2approved AT indriyadeviindra correlationbetweencd44cancerstemcellexpressionandhistopathologicaltypesofnasopharyngealcarcinomaversion2peerreview2approved AT sriherawatijuniati correlationbetweencd44cancerstemcellexpressionandhistopathologicaltypesofnasopharyngealcarcinomaversion2peerreview2approved AT yussyafrianidewi correlationbetweencd44cancerstemcellexpressionandhistopathologicaltypesofnasopharyngealcarcinomaversion2peerreview2approved
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Correlation between CD44+ cancer stem cell expression and histopathological types of nasopharyngeal carcinoma [version 2; peer review: 2 approved]

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