Combination of Trans-Resveratrol and ε-Viniferin Induces a Hepatoprotective Effect in Rats with Severe Acute Liver Failure via Reduction of Oxidative Stress and MMP-9 Expression

Stilbenes are a major grapevine class of phenolic compounds, known for their biological activities, including anti-inflammatory and antioxidant, but never studied in combination. We aimed to evaluate the effect of trans-resveratrol + ε-viniferin as an antioxidant mixture and its role in inflammatory...

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Autores principales:	João C. Fernandes, Elizângela G. Schemitt, Juliana Da Silva, Norma P. Marroni, Ana Lima, Ricardo B. Ferreira
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	inflammation liver failure MMP-9 oxidative stress resveratrol stilbenes Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/7b529d76ec1e494d89e6b071e9dd8af6
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spelling	oai:doaj.org-article:7b529d76ec1e494d89e6b071e9dd8af62021-11-25T18:33:06ZCombination of Trans-Resveratrol and ε-Viniferin Induces a Hepatoprotective Effect in Rats with Severe Acute Liver Failure via Reduction of Oxidative Stress and MMP-9 Expression10.3390/nu131136772072-6643https://doaj.org/article/7b529d76ec1e494d89e6b071e9dd8af62021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3677https://doaj.org/toc/2072-6643Stilbenes are a major grapevine class of phenolic compounds, known for their biological activities, including anti-inflammatory and antioxidant, but never studied in combination. We aimed to evaluate the effect of trans-resveratrol + ε-viniferin as an antioxidant mixture and its role in inflammatory development an in vivo model of severe acute liver failure induced with TAA. Trans-resveratrol + trans-ε-viniferin (5 mg/kg each) was administered to Wistar rats. Resveratrol + ε-viniferin significantly decreased TBARS and SOD activity and restored CAT and GST activities in the treated group. This stilbene combination reduced the expression of TNFα, iNOS, and COX-2, and inhibited MMP-9. The combination of resveratrol + ε-viniferin had a hepatoprotective effect, reducing DNA damage, exhibiting a protective role on the antioxidant pathway by altering SOD, CAT, and GST activities; by downregulating TNFα, COX-2, and iNOS; and upregulating IL-10. Our results suggested that adding viniferin to resveratrol may be more effective in hepatoprotection than resveratrol alone, opening a new perspective on using this stilbene combination in functional diets.João C. FernandesElizângela G. SchemittJuliana Da SilvaNorma P. MarroniAna LimaRicardo B. FerreiraMDPI AGarticleinflammationliver failureMMP-9oxidative stressresveratrolstilbenesNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3677, p 3677 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	inflammation liver failure MMP-9 oxidative stress resveratrol stilbenes Nutrition. Foods and food supply TX341-641
spellingShingle	inflammation liver failure MMP-9 oxidative stress resveratrol stilbenes Nutrition. Foods and food supply TX341-641 João C. Fernandes Elizângela G. Schemitt Juliana Da Silva Norma P. Marroni Ana Lima Ricardo B. Ferreira Combination of Trans-Resveratrol and ε-Viniferin Induces a Hepatoprotective Effect in Rats with Severe Acute Liver Failure via Reduction of Oxidative Stress and MMP-9 Expression
description	Stilbenes are a major grapevine class of phenolic compounds, known for their biological activities, including anti-inflammatory and antioxidant, but never studied in combination. We aimed to evaluate the effect of trans-resveratrol + ε-viniferin as an antioxidant mixture and its role in inflammatory development an in vivo model of severe acute liver failure induced with TAA. Trans-resveratrol + trans-ε-viniferin (5 mg/kg each) was administered to Wistar rats. Resveratrol + ε-viniferin significantly decreased TBARS and SOD activity and restored CAT and GST activities in the treated group. This stilbene combination reduced the expression of TNFα, iNOS, and COX-2, and inhibited MMP-9. The combination of resveratrol + ε-viniferin had a hepatoprotective effect, reducing DNA damage, exhibiting a protective role on the antioxidant pathway by altering SOD, CAT, and GST activities; by downregulating TNFα, COX-2, and iNOS; and upregulating IL-10. Our results suggested that adding viniferin to resveratrol may be more effective in hepatoprotection than resveratrol alone, opening a new perspective on using this stilbene combination in functional diets.
format	article
author	João C. Fernandes Elizângela G. Schemitt Juliana Da Silva Norma P. Marroni Ana Lima Ricardo B. Ferreira
author_facet	João C. Fernandes Elizângela G. Schemitt Juliana Da Silva Norma P. Marroni Ana Lima Ricardo B. Ferreira
author_sort	João C. Fernandes
title	Combination of Trans-Resveratrol and ε-Viniferin Induces a Hepatoprotective Effect in Rats with Severe Acute Liver Failure via Reduction of Oxidative Stress and MMP-9 Expression
title_short	Combination of Trans-Resveratrol and ε-Viniferin Induces a Hepatoprotective Effect in Rats with Severe Acute Liver Failure via Reduction of Oxidative Stress and MMP-9 Expression
title_full	Combination of Trans-Resveratrol and ε-Viniferin Induces a Hepatoprotective Effect in Rats with Severe Acute Liver Failure via Reduction of Oxidative Stress and MMP-9 Expression
title_fullStr	Combination of Trans-Resveratrol and ε-Viniferin Induces a Hepatoprotective Effect in Rats with Severe Acute Liver Failure via Reduction of Oxidative Stress and MMP-9 Expression
title_full_unstemmed	Combination of Trans-Resveratrol and ε-Viniferin Induces a Hepatoprotective Effect in Rats with Severe Acute Liver Failure via Reduction of Oxidative Stress and MMP-9 Expression
title_sort	combination of trans-resveratrol and ε-viniferin induces a hepatoprotective effect in rats with severe acute liver failure via reduction of oxidative stress and mmp-9 expression
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7b529d76ec1e494d89e6b071e9dd8af6
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Combination of Trans-Resveratrol and ε-Viniferin Induces a Hepatoprotective Effect in Rats with Severe Acute Liver Failure via Reduction of Oxidative Stress and MMP-9 Expression

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