The Clinicopathological Features and Overall Survival of Patients With Gastric Neuroendocrine Carcinoma

Objectives: Gastric neuroendocrine carcinoma (GNEC) is a class of rare histological subtypes in gastric cancer (GC). This retrospective case-control study aimed to explore the clinicopathological features and overall survival (OS) of patients with GNEC. Methods: A large population of GNEC and intest...

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Autores principales:	Bin Xu MD, Yuxin Chu MD, Qinyong Hu MD, Qibin Song MD
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/7b52e8d6ac874ed79d7f8192ab4e28ab
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spelling	oai:doaj.org-article:7b52e8d6ac874ed79d7f8192ab4e28ab2021-11-21T02:04:31ZThe Clinicopathological Features and Overall Survival of Patients With Gastric Neuroendocrine Carcinoma1533-033810.1177/15330338211055340https://doaj.org/article/7b52e8d6ac874ed79d7f8192ab4e28ab2021-11-01T00:00:00Zhttps://doi.org/10.1177/15330338211055340https://doaj.org/toc/1533-0338Objectives: Gastric neuroendocrine carcinoma (GNEC) is a class of rare histological subtypes in gastric cancer (GC). This retrospective case-control study aimed to explore the clinicopathological features and overall survival (OS) of patients with GNEC. Methods: A large population of GNEC and intestinal-type GC (IGC) patients were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. The 1:1 propensity score matching (PSM) analysis was initiated to adjust the confounders between GNEC and IGC cohorts. Kaplan-Meier (KM) plots with log-rank tests were used to compare the survival differences in GNEC versus IGC. Additionally, Cox proportional hazard regression models were adopted to characterize the prognostic factors relevant to OS of the GNEC patients. Results: An entity of 4596 patients were collected, including 3943 (85.8%) IGC patients and 653 (14.2%) GNEC patients. The PSM analysis well-balanced all confounders in GNEC versus IGC (all P > .05). The KM plots showed that GNEC had significantly superior OS to IGC both before and after PSM analysis. Before PSM, the median OS was 52 (33.6-70.4) months in GNEC versus 32 (29.3-34.7) months in IGC ( P = .0015). After PSM, the median OS was 26 (18.3-33.7) months in GNEC versus 21 (17.7-24.3) months in IGC ( P = .0039). Stratified analysis indicated that GNEC had superior survivals to IGC in early stage patients and those who received surgery. In Cox regression analysis, age ≥ 60, tumor size > 50 mm, stage II-IV, T2, and N3 were independent risk factors for the GNEC patients (hazard ratio [HR]>1, P < .05). By contrast, year 2010 to 2015, female, and surgery were independent protective factors for these patients (HR < 1, P < .05). Conclusions: GNEC has unique clinicopathological features quite different from IGC and may have a superior survival to IGC in early stage patients. The prognostic factors identified here may assist the clinicians to more individually treat these patients.Bin Xu MDYuxin Chu MDQinyong Hu MDQibin Song MDSAGE PublishingarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENTechnology in Cancer Research & Treatment, Vol 20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Bin Xu MD Yuxin Chu MD Qinyong Hu MD Qibin Song MD The Clinicopathological Features and Overall Survival of Patients With Gastric Neuroendocrine Carcinoma
description	Objectives: Gastric neuroendocrine carcinoma (GNEC) is a class of rare histological subtypes in gastric cancer (GC). This retrospective case-control study aimed to explore the clinicopathological features and overall survival (OS) of patients with GNEC. Methods: A large population of GNEC and intestinal-type GC (IGC) patients were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. The 1:1 propensity score matching (PSM) analysis was initiated to adjust the confounders between GNEC and IGC cohorts. Kaplan-Meier (KM) plots with log-rank tests were used to compare the survival differences in GNEC versus IGC. Additionally, Cox proportional hazard regression models were adopted to characterize the prognostic factors relevant to OS of the GNEC patients. Results: An entity of 4596 patients were collected, including 3943 (85.8%) IGC patients and 653 (14.2%) GNEC patients. The PSM analysis well-balanced all confounders in GNEC versus IGC (all P > .05). The KM plots showed that GNEC had significantly superior OS to IGC both before and after PSM analysis. Before PSM, the median OS was 52 (33.6-70.4) months in GNEC versus 32 (29.3-34.7) months in IGC ( P = .0015). After PSM, the median OS was 26 (18.3-33.7) months in GNEC versus 21 (17.7-24.3) months in IGC ( P = .0039). Stratified analysis indicated that GNEC had superior survivals to IGC in early stage patients and those who received surgery. In Cox regression analysis, age ≥ 60, tumor size > 50 mm, stage II-IV, T2, and N3 were independent risk factors for the GNEC patients (hazard ratio [HR]>1, P < .05). By contrast, year 2010 to 2015, female, and surgery were independent protective factors for these patients (HR < 1, P < .05). Conclusions: GNEC has unique clinicopathological features quite different from IGC and may have a superior survival to IGC in early stage patients. The prognostic factors identified here may assist the clinicians to more individually treat these patients.
format	article
author	Bin Xu MD Yuxin Chu MD Qinyong Hu MD Qibin Song MD
author_facet	Bin Xu MD Yuxin Chu MD Qinyong Hu MD Qibin Song MD
author_sort	Bin Xu MD
title	The Clinicopathological Features and Overall Survival of Patients With Gastric Neuroendocrine Carcinoma
title_short	The Clinicopathological Features and Overall Survival of Patients With Gastric Neuroendocrine Carcinoma
title_full	The Clinicopathological Features and Overall Survival of Patients With Gastric Neuroendocrine Carcinoma
title_fullStr	The Clinicopathological Features and Overall Survival of Patients With Gastric Neuroendocrine Carcinoma
title_full_unstemmed	The Clinicopathological Features and Overall Survival of Patients With Gastric Neuroendocrine Carcinoma
title_sort	clinicopathological features and overall survival of patients with gastric neuroendocrine carcinoma
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/7b52e8d6ac874ed79d7f8192ab4e28ab
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The Clinicopathological Features and Overall Survival of Patients With Gastric Neuroendocrine Carcinoma

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