EpCAM promotes endosomal modulation of the cortical RhoA zone for epithelial organization

The organization and force-generating property of actomyosin dictate the plasticity and behaviour of cells but the spatio-temporal regulation of this network is unclear. Here, the authors show that coupling between EpCAM/RhoA co-trafficking and actomyosin rearrangement is pivotal during cell spreadi...

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Autores principales:	Cécile Gaston, Simon De Beco, Bryant Doss, Meng Pan, Estelle Gauquelin, Joseph D’Alessandro, Chwee Teck Lim, Benoit Ladoux, Delphine Delacour
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7b55341483d34cfa93325ca1970195c7
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spelling	oai:doaj.org-article:7b55341483d34cfa93325ca1970195c72021-12-02T18:03:13ZEpCAM promotes endosomal modulation of the cortical RhoA zone for epithelial organization10.1038/s41467-021-22482-92041-1723https://doaj.org/article/7b55341483d34cfa93325ca1970195c72021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22482-9https://doaj.org/toc/2041-1723The organization and force-generating property of actomyosin dictate the plasticity and behaviour of cells but the spatio-temporal regulation of this network is unclear. Here, the authors show that coupling between EpCAM/RhoA co-trafficking and actomyosin rearrangement is pivotal during cell spreading and polarization.Cécile GastonSimon De BecoBryant DossMeng PanEstelle GauquelinJoseph D’AlessandroChwee Teck LimBenoit LadouxDelphine DelacourNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cécile Gaston Simon De Beco Bryant Doss Meng Pan Estelle Gauquelin Joseph D’Alessandro Chwee Teck Lim Benoit Ladoux Delphine Delacour EpCAM promotes endosomal modulation of the cortical RhoA zone for epithelial organization
description	The organization and force-generating property of actomyosin dictate the plasticity and behaviour of cells but the spatio-temporal regulation of this network is unclear. Here, the authors show that coupling between EpCAM/RhoA co-trafficking and actomyosin rearrangement is pivotal during cell spreading and polarization.
format	article
author	Cécile Gaston Simon De Beco Bryant Doss Meng Pan Estelle Gauquelin Joseph D’Alessandro Chwee Teck Lim Benoit Ladoux Delphine Delacour
author_facet	Cécile Gaston Simon De Beco Bryant Doss Meng Pan Estelle Gauquelin Joseph D’Alessandro Chwee Teck Lim Benoit Ladoux Delphine Delacour
author_sort	Cécile Gaston
title	EpCAM promotes endosomal modulation of the cortical RhoA zone for epithelial organization
title_short	EpCAM promotes endosomal modulation of the cortical RhoA zone for epithelial organization
title_full	EpCAM promotes endosomal modulation of the cortical RhoA zone for epithelial organization
title_fullStr	EpCAM promotes endosomal modulation of the cortical RhoA zone for epithelial organization
title_full_unstemmed	EpCAM promotes endosomal modulation of the cortical RhoA zone for epithelial organization
title_sort	epcam promotes endosomal modulation of the cortical rhoa zone for epithelial organization
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7b55341483d34cfa93325ca1970195c7
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EpCAM promotes endosomal modulation of the cortical RhoA zone for epithelial organization

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