Evaluation of plasma levels of neopterin and soluble CD40 ligand in patients with acute ischemic stroke in upper Egypt: can they surrogate the severity and functional outcome?

Abeer A Tony,1 Effat AE Tony,2 Wafaa Salah Mohammed,3 Emad F Kholef3 1Department of Neuropsychiatry, Faculty of Medicine, Aswan University, Aswan, Egypt; 2Department of Internal Medicine, Nephrology Unit, Faculty of Medicine, Assuit University, Assuit, Egypt; 3Department of Clinical Pathology, Facul...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tony AA, Tony EAE, Mohammed WS, Kholef EF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Acute ischemic stroke Soluble CD40 Ligand neopetrin stroke risk factors and functional outcome SSS: Scandinavian stroke scale mRS: modified Rankin scale. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/7b561b069bac4e54b4bbdde5edbd10a8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7b561b069bac4e54b4bbdde5edbd10a8
record_format	dspace
spelling	oai:doaj.org-article:7b561b069bac4e54b4bbdde5edbd10a82021-12-02T04:16:24ZEvaluation of plasma levels of neopterin and soluble CD40 ligand in patients with acute ischemic stroke in upper Egypt: can they surrogate the severity and functional outcome?1178-2021https://doaj.org/article/7b561b069bac4e54b4bbdde5edbd10a82019-02-01T00:00:00Zhttps://www.dovepress.com/evaluation-of-plasma-levels-of-neopterin-and-soluble-cd40-ligand-in-pa-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Abeer A Tony,1 Effat AE Tony,2 Wafaa Salah Mohammed,3 Emad F Kholef3 1Department of Neuropsychiatry, Faculty of Medicine, Aswan University, Aswan, Egypt; 2Department of Internal Medicine, Nephrology Unit, Faculty of Medicine, Assuit University, Assuit, Egypt; 3Department of Clinical Pathology, Faculty of Medicine, Aswan University, Aswan, Egypt Background: Inflammation constitutes a major component of ischemic stroke pathology. The prognostic value of “neopterin” and soluble CD40 ligand (sCD40L), as a potential biomarker of ischemic stroke, has been less extensively studied.Objectives of the study: This study aims at assessing the serum levels of neopterin and sCD40L in acute ischemic stroke (AIS), to clarify its association with the severity, etiology, and risk factors of stroke, and to evaluate their relationship with the stroke functional outcome in our study sample within 90 days of follow-up.Study sample: This case–control study was conducted on 100 patients with first-ever acute onset ischemic stroke and 25 control subjects.Methods: Participants were subjected to full history taking and detailed clinical and neurological examination. Brain imaging was performed after hospital admission. Blood tests were drawn for assessment of neopterin and sCD40L on the first day of admission.Results: High levels of neopterin and sCD40L was reported. Their levels were significantly higher in relation with survival status. There was a relationship between AIS and sCD40L levels and the severity of the stroke. Within 3 months of follow-up, these biomarkers were associated significantly with poor functional outcome, within a 90-day follow-up period, and mortality. These biomarkers were highly associated in patients with small vessel occlusion as an etiology for AIS.Conclusion: Neopterin and sCD40L levels increased after AIS. Both biomarkers were strong and independent predictors of 90-day unfavorable clinical outcome and death in patients after AIS. Keywords: acute ischemic stroke, soluble CD40 ligand, neopterin, stroke risk factors, functional outcome  Tony AATony EAEMohammed WSKholef EFDove Medical PressarticleAcute ischemic strokeSoluble CD40 Ligandneopetrinstroke risk factors and functional outcomeSSS: Scandinavian stroke scalemRS: modified Rankin scale.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 575-586 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Acute ischemic stroke Soluble CD40 Ligand neopetrin stroke risk factors and functional outcome SSS: Scandinavian stroke scale mRS: modified Rankin scale. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Acute ischemic stroke Soluble CD40 Ligand neopetrin stroke risk factors and functional outcome SSS: Scandinavian stroke scale mRS: modified Rankin scale. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Tony AA Tony EAE Mohammed WS Kholef EF Evaluation of plasma levels of neopterin and soluble CD40 ligand in patients with acute ischemic stroke in upper Egypt: can they surrogate the severity and functional outcome?
description	Abeer A Tony,1 Effat AE Tony,2 Wafaa Salah Mohammed,3 Emad F Kholef3 1Department of Neuropsychiatry, Faculty of Medicine, Aswan University, Aswan, Egypt; 2Department of Internal Medicine, Nephrology Unit, Faculty of Medicine, Assuit University, Assuit, Egypt; 3Department of Clinical Pathology, Faculty of Medicine, Aswan University, Aswan, Egypt Background: Inflammation constitutes a major component of ischemic stroke pathology. The prognostic value of “neopterin” and soluble CD40 ligand (sCD40L), as a potential biomarker of ischemic stroke, has been less extensively studied.Objectives of the study: This study aims at assessing the serum levels of neopterin and sCD40L in acute ischemic stroke (AIS), to clarify its association with the severity, etiology, and risk factors of stroke, and to evaluate their relationship with the stroke functional outcome in our study sample within 90 days of follow-up.Study sample: This case–control study was conducted on 100 patients with first-ever acute onset ischemic stroke and 25 control subjects.Methods: Participants were subjected to full history taking and detailed clinical and neurological examination. Brain imaging was performed after hospital admission. Blood tests were drawn for assessment of neopterin and sCD40L on the first day of admission.Results: High levels of neopterin and sCD40L was reported. Their levels were significantly higher in relation with survival status. There was a relationship between AIS and sCD40L levels and the severity of the stroke. Within 3 months of follow-up, these biomarkers were associated significantly with poor functional outcome, within a 90-day follow-up period, and mortality. These biomarkers were highly associated in patients with small vessel occlusion as an etiology for AIS.Conclusion: Neopterin and sCD40L levels increased after AIS. Both biomarkers were strong and independent predictors of 90-day unfavorable clinical outcome and death in patients after AIS. Keywords: acute ischemic stroke, soluble CD40 ligand, neopterin, stroke risk factors, functional outcome
format	article
author	Tony AA Tony EAE Mohammed WS Kholef EF
author_facet	Tony AA Tony EAE Mohammed WS Kholef EF
author_sort	Tony AA
title	Evaluation of plasma levels of neopterin and soluble CD40 ligand in patients with acute ischemic stroke in upper Egypt: can they surrogate the severity and functional outcome?
title_short	Evaluation of plasma levels of neopterin and soluble CD40 ligand in patients with acute ischemic stroke in upper Egypt: can they surrogate the severity and functional outcome?
title_full	Evaluation of plasma levels of neopterin and soluble CD40 ligand in patients with acute ischemic stroke in upper Egypt: can they surrogate the severity and functional outcome?
title_fullStr	Evaluation of plasma levels of neopterin and soluble CD40 ligand in patients with acute ischemic stroke in upper Egypt: can they surrogate the severity and functional outcome?
title_full_unstemmed	Evaluation of plasma levels of neopterin and soluble CD40 ligand in patients with acute ischemic stroke in upper Egypt: can they surrogate the severity and functional outcome?
title_sort	evaluation of plasma levels of neopterin and soluble cd40 ligand in patients with acute ischemic stroke in upper egypt: can they surrogate the severity and functional outcome?
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/7b561b069bac4e54b4bbdde5edbd10a8
work_keys_str_mv	AT tonyaa evaluationofplasmalevelsofneopterinandsolublecd40ligandinpatientswithacuteischemicstrokeinupperegyptcantheysurrogatetheseverityandfunctionaloutcome AT tonyeae evaluationofplasmalevelsofneopterinandsolublecd40ligandinpatientswithacuteischemicstrokeinupperegyptcantheysurrogatetheseverityandfunctionaloutcome AT mohammedws evaluationofplasmalevelsofneopterinandsolublecd40ligandinpatientswithacuteischemicstrokeinupperegyptcantheysurrogatetheseverityandfunctionaloutcome AT kholefef evaluationofplasmalevelsofneopterinandsolublecd40ligandinpatientswithacuteischemicstrokeinupperegyptcantheysurrogatetheseverityandfunctionaloutcome
_version_	1718401380875501568

Evaluation of plasma levels of neopterin and soluble CD40 ligand in patients with acute ischemic stroke in upper Egypt: can they surrogate the severity and functional outcome?

Ejemplares similares