Non-toxic polymer nanovectors for improved delivery of dexamethasone

Abstract Dexamethasone (Dex) is a highly insoluble front-line drug used in cancer therapy. Data from clinical trials indicates that the pharmacokinetics of Dex vary considerably between patients and prolonging drug exposure rather than increasing absolute dose may improve efficacy. Non-toxic, fully...

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Autores principales:	Benjamin C. Ede, Paraskevi Diamanti, David S. Williams, Allison Blair
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7b565fee84e34ae2a46e1d888530d47a
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spelling	oai:doaj.org-article:7b565fee84e34ae2a46e1d888530d47a2021-12-02T18:53:19ZNon-toxic polymer nanovectors for improved delivery of dexamethasone10.1038/s41598-021-96797-42045-2322https://doaj.org/article/7b565fee84e34ae2a46e1d888530d47a2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96797-4https://doaj.org/toc/2045-2322Abstract Dexamethasone (Dex) is a highly insoluble front-line drug used in cancer therapy. Data from clinical trials indicates that the pharmacokinetics of Dex vary considerably between patients and prolonging drug exposure rather than increasing absolute dose may improve efficacy. Non-toxic, fully biodegradable Dex loaded nanovectors (NV) were formulated, via simple direct hydration within 10 min, as a vehicle to extend exposure and distribution in vivo. Dex-NV were just as effective as the free drug against primary human leukemia cells in vitro and in vivo. Importantly, high levels of DMSO solvent were not required in the NV formulations. Broad distribution of NV was seen rapidly following inoculation into mice. NV accumulated in major organs, including bone marrow and brain, known sanctuary sites for ALL. The study describes a non-toxic, more easily scalable system for improving Dex solubility for use in cancer and can be applied to other medical conditions associated with inflammation.Benjamin C. EdeParaskevi DiamantiDavid S. WilliamsAllison BlairNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Benjamin C. Ede Paraskevi Diamanti David S. Williams Allison Blair Non-toxic polymer nanovectors for improved delivery of dexamethasone
description	Abstract Dexamethasone (Dex) is a highly insoluble front-line drug used in cancer therapy. Data from clinical trials indicates that the pharmacokinetics of Dex vary considerably between patients and prolonging drug exposure rather than increasing absolute dose may improve efficacy. Non-toxic, fully biodegradable Dex loaded nanovectors (NV) were formulated, via simple direct hydration within 10 min, as a vehicle to extend exposure and distribution in vivo. Dex-NV were just as effective as the free drug against primary human leukemia cells in vitro and in vivo. Importantly, high levels of DMSO solvent were not required in the NV formulations. Broad distribution of NV was seen rapidly following inoculation into mice. NV accumulated in major organs, including bone marrow and brain, known sanctuary sites for ALL. The study describes a non-toxic, more easily scalable system for improving Dex solubility for use in cancer and can be applied to other medical conditions associated with inflammation.
format	article
author	Benjamin C. Ede Paraskevi Diamanti David S. Williams Allison Blair
author_facet	Benjamin C. Ede Paraskevi Diamanti David S. Williams Allison Blair
author_sort	Benjamin C. Ede
title	Non-toxic polymer nanovectors for improved delivery of dexamethasone
title_short	Non-toxic polymer nanovectors for improved delivery of dexamethasone
title_full	Non-toxic polymer nanovectors for improved delivery of dexamethasone
title_fullStr	Non-toxic polymer nanovectors for improved delivery of dexamethasone
title_full_unstemmed	Non-toxic polymer nanovectors for improved delivery of dexamethasone
title_sort	non-toxic polymer nanovectors for improved delivery of dexamethasone
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7b565fee84e34ae2a46e1d888530d47a
work_keys_str_mv	AT benjamincede nontoxicpolymernanovectorsforimproveddeliveryofdexamethasone AT paraskevidiamanti nontoxicpolymernanovectorsforimproveddeliveryofdexamethasone AT davidswilliams nontoxicpolymernanovectorsforimproveddeliveryofdexamethasone AT allisonblair nontoxicpolymernanovectorsforimproveddeliveryofdexamethasone
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Non-toxic polymer nanovectors for improved delivery of dexamethasone

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