Asymmetric excitatory synaptic dynamics underlie interaural time difference processing in the auditory system.

Low-frequency sound localization depends on the neural computation of interaural time differences (ITD) and relies on neurons in the auditory brain stem that integrate synaptic inputs delivered by the ipsi- and contralateral auditory pathways that start at the two ears. The first auditory neurons th...

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Autores principales:	Pablo E Jercog, Gytis Svirskis, Vibhakar C Kotak, Dan H Sanes, John Rinzel
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/7b5758b4213c476fba31abb5cfeb96ed
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spelling	oai:doaj.org-article:7b5758b4213c476fba31abb5cfeb96ed2021-12-02T19:54:47ZAsymmetric excitatory synaptic dynamics underlie interaural time difference processing in the auditory system.1544-91731545-788510.1371/journal.pbio.1000406https://doaj.org/article/7b5758b4213c476fba31abb5cfeb96ed2010-06-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20613857/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Low-frequency sound localization depends on the neural computation of interaural time differences (ITD) and relies on neurons in the auditory brain stem that integrate synaptic inputs delivered by the ipsi- and contralateral auditory pathways that start at the two ears. The first auditory neurons that respond selectively to ITD are found in the medial superior olivary nucleus (MSO). We identified a new mechanism for ITD coding using a brain slice preparation that preserves the binaural inputs to the MSO. There was an internal latency difference for the two excitatory pathways that would, if left uncompensated, position the ITD response function too far outside the physiological range to be useful for estimating ITD. We demonstrate, and support using a biophysically based computational model, that a bilateral asymmetry in excitatory post-synaptic potential (EPSP) slopes provides a robust compensatory delay mechanism due to differential activation of low threshold potassium conductance on these inputs and permits MSO neurons to encode physiological ITDs. We suggest, more generally, that the dependence of spike probability on rate of depolarization, as in these auditory neurons, provides a mechanism for temporal order discrimination between EPSPs.Pablo E JercogGytis SvirskisVibhakar C KotakDan H SanesJohn RinzelPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 8, Iss 6, p e1000406 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Pablo E Jercog Gytis Svirskis Vibhakar C Kotak Dan H Sanes John Rinzel Asymmetric excitatory synaptic dynamics underlie interaural time difference processing in the auditory system.
description	Low-frequency sound localization depends on the neural computation of interaural time differences (ITD) and relies on neurons in the auditory brain stem that integrate synaptic inputs delivered by the ipsi- and contralateral auditory pathways that start at the two ears. The first auditory neurons that respond selectively to ITD are found in the medial superior olivary nucleus (MSO). We identified a new mechanism for ITD coding using a brain slice preparation that preserves the binaural inputs to the MSO. There was an internal latency difference for the two excitatory pathways that would, if left uncompensated, position the ITD response function too far outside the physiological range to be useful for estimating ITD. We demonstrate, and support using a biophysically based computational model, that a bilateral asymmetry in excitatory post-synaptic potential (EPSP) slopes provides a robust compensatory delay mechanism due to differential activation of low threshold potassium conductance on these inputs and permits MSO neurons to encode physiological ITDs. We suggest, more generally, that the dependence of spike probability on rate of depolarization, as in these auditory neurons, provides a mechanism for temporal order discrimination between EPSPs.
format	article
author	Pablo E Jercog Gytis Svirskis Vibhakar C Kotak Dan H Sanes John Rinzel
author_facet	Pablo E Jercog Gytis Svirskis Vibhakar C Kotak Dan H Sanes John Rinzel
author_sort	Pablo E Jercog
title	Asymmetric excitatory synaptic dynamics underlie interaural time difference processing in the auditory system.
title_short	Asymmetric excitatory synaptic dynamics underlie interaural time difference processing in the auditory system.
title_full	Asymmetric excitatory synaptic dynamics underlie interaural time difference processing in the auditory system.
title_fullStr	Asymmetric excitatory synaptic dynamics underlie interaural time difference processing in the auditory system.
title_full_unstemmed	Asymmetric excitatory synaptic dynamics underlie interaural time difference processing in the auditory system.
title_sort	asymmetric excitatory synaptic dynamics underlie interaural time difference processing in the auditory system.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/7b5758b4213c476fba31abb5cfeb96ed
work_keys_str_mv	AT pabloejercog asymmetricexcitatorysynapticdynamicsunderlieinterauraltimedifferenceprocessingintheauditorysystem AT gytissvirskis asymmetricexcitatorysynapticdynamicsunderlieinterauraltimedifferenceprocessingintheauditorysystem AT vibhakarckotak asymmetricexcitatorysynapticdynamicsunderlieinterauraltimedifferenceprocessingintheauditorysystem AT danhsanes asymmetricexcitatorysynapticdynamicsunderlieinterauraltimedifferenceprocessingintheauditorysystem AT johnrinzel asymmetricexcitatorysynapticdynamicsunderlieinterauraltimedifferenceprocessingintheauditorysystem
_version_	1718375848682192896

Asymmetric excitatory synaptic dynamics underlie interaural time difference processing in the auditory system.

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