The effect of a geometric-shaped tool with blue led light on the activation of human dermal fibroblasts and cancer cells

Light-emitting diode (LED) irradiation has been used as a therapeutic technique for several diseases. It is known that energy levels of light change according to different surfaces, colors and geometric shapes. However, more information is needed regarding the effect of this change on the human body...

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Autores principales:	Ebru Kilicarslan Toruner, Handan Kayhan, Fatih Suheyl Ezgu
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Light Geometrical spiral Neuroblastoma Fibroblast Apoptosis Wound closure Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/7b59a573cba9457bb493bef12a191674
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spelling	oai:doaj.org-article:7b59a573cba9457bb493bef12a1916742021-11-26T04:41:01ZThe effect of a geometric-shaped tool with blue led light on the activation of human dermal fibroblasts and cancer cells2666-469010.1016/j.jpap.2021.100087https://doaj.org/article/7b59a573cba9457bb493bef12a1916742021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2666469021000725https://doaj.org/toc/2666-4690Light-emitting diode (LED) irradiation has been used as a therapeutic technique for several diseases. It is known that energy levels of light change according to different surfaces, colors and geometric shapes. However, more information is needed regarding the effect of this change on the human body. This study was aimed to investigate the effect of blue LED light applied through an optical path with special geometry on the human dermal fibroblast (HDF) and cancer cell proliferation, apoptosis, migration, and cell cycle. The number of cancerous cells was found to be lower and the rate of necrosis was determined to be significantly higher in the geometrical light-treated group than in the direct light and non-light groups. The migration of HDF cells in blue LED light in the geometrical tool group increased more than the other groups after 72 h of light irradiation. In cancer cells, the wound closure rate of the non-light group was higher than light-exposed groups after 72 h. Blue LED light induces a G1 phase peak followed by apoptosis in cancer cells 24 h after light irradiation, especially in the geometrical tool group. These results indicate that blue LED irradiation applied through an optical path with a special geometrical tool inhibits cancer cell proliferation, migration, and induces cell necrosis.Ebru Kilicarslan TorunerHandan KayhanFatih Suheyl EzguElsevierarticleLightGeometrical spiralNeuroblastomaFibroblastApoptosisWound closureChemistryQD1-999ENJournal of Photochemistry and Photobiology, Vol 8, Iss , Pp 100087- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Light Geometrical spiral Neuroblastoma Fibroblast Apoptosis Wound closure Chemistry QD1-999
spellingShingle	Light Geometrical spiral Neuroblastoma Fibroblast Apoptosis Wound closure Chemistry QD1-999 Ebru Kilicarslan Toruner Handan Kayhan Fatih Suheyl Ezgu The effect of a geometric-shaped tool with blue led light on the activation of human dermal fibroblasts and cancer cells
description	Light-emitting diode (LED) irradiation has been used as a therapeutic technique for several diseases. It is known that energy levels of light change according to different surfaces, colors and geometric shapes. However, more information is needed regarding the effect of this change on the human body. This study was aimed to investigate the effect of blue LED light applied through an optical path with special geometry on the human dermal fibroblast (HDF) and cancer cell proliferation, apoptosis, migration, and cell cycle. The number of cancerous cells was found to be lower and the rate of necrosis was determined to be significantly higher in the geometrical light-treated group than in the direct light and non-light groups. The migration of HDF cells in blue LED light in the geometrical tool group increased more than the other groups after 72 h of light irradiation. In cancer cells, the wound closure rate of the non-light group was higher than light-exposed groups after 72 h. Blue LED light induces a G1 phase peak followed by apoptosis in cancer cells 24 h after light irradiation, especially in the geometrical tool group. These results indicate that blue LED irradiation applied through an optical path with a special geometrical tool inhibits cancer cell proliferation, migration, and induces cell necrosis.
format	article
author	Ebru Kilicarslan Toruner Handan Kayhan Fatih Suheyl Ezgu
author_facet	Ebru Kilicarslan Toruner Handan Kayhan Fatih Suheyl Ezgu
author_sort	Ebru Kilicarslan Toruner
title	The effect of a geometric-shaped tool with blue led light on the activation of human dermal fibroblasts and cancer cells
title_short	The effect of a geometric-shaped tool with blue led light on the activation of human dermal fibroblasts and cancer cells
title_full	The effect of a geometric-shaped tool with blue led light on the activation of human dermal fibroblasts and cancer cells
title_fullStr	The effect of a geometric-shaped tool with blue led light on the activation of human dermal fibroblasts and cancer cells
title_full_unstemmed	The effect of a geometric-shaped tool with blue led light on the activation of human dermal fibroblasts and cancer cells
title_sort	effect of a geometric-shaped tool with blue led light on the activation of human dermal fibroblasts and cancer cells
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/7b59a573cba9457bb493bef12a191674
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The effect of a geometric-shaped tool with blue led light on the activation of human dermal fibroblasts and cancer cells

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