The effect of hydroalcoholic extract of Achillea Millefolium on analgesic effect of Morphine in rats

Objective: Achillea millefolium is a plant whose anti-inflammatory effects were proved by inhibition of cyclooxygenase enzyme activities. In this study, the effect of its hydroalcoholic extract on analgesic effect of morphine was investigated to lower the dose of injected morphine as much as possibl...

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Autores principales:	A, Arzi, M Akhavan
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2001
Materias:	achillea millefolium morphine pain rat Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7b5d4d7ec7bb41f2be7202de4e4295e2
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id	oai:doaj.org-article:7b5d4d7ec7bb41f2be7202de4e4295e2
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spelling	oai:doaj.org-article:7b5d4d7ec7bb41f2be7202de4e4295e22021-11-10T09:21:13ZThe effect of hydroalcoholic extract of Achillea Millefolium on analgesic effect of Morphine in rats1561-41072251-7170https://doaj.org/article/7b5d4d7ec7bb41f2be7202de4e4295e22001-10-01T00:00:00Zhttp://jbums.org/article-1-2846-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170Objective: Achillea millefolium is a plant whose anti-inflammatory effects were proved by inhibition of cyclooxygenase enzyme activities. In this study, the effect of its hydroalcoholic extract on analgesic effect of morphine was investigated to lower the dose of injected morphine as much as possible. Methods: This study was performed on rats by tail flick test. At first a suitable dose of morphine that caused analgesia was selected by dose response method. Then analgesic effect of different doses of achillea millefolium extract (25, 50, 75 and 100 mg/kg) and also the effect of these doses on analgesic effect of a suitable dose of morphine (2.5 mg/kg) were investigated. Findings: According to the results and by using analytical variance method, the best dose of extract selected for improving the analgesic effect of morphine was 75 mg/kg (P<0.05). Reflex time in control group to alogenic stimulant was about 2-3 seconds and in rats, which received different doses of hydroalcoholic, extract of achillea millefolium before injection of morphine (2.5 mg/kg) in comparison to those which only received morphine showed a significant increase (P<0.05). Conclusion: All doses of hydroalcoholic extract of achillea millefolium caused an increase of analgesic effect of morphine significantly (P<0.05). Meanwhile, the strongest effect was observed at 45th minute of the trial.A, ArziM AkhavanBabol University of Medical Sciencesarticleachillea millefoliummorphinepainratMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 3, Iss 4, Pp 11-14 (2001)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	achillea millefolium morphine pain rat Medicine R Medicine (General) R5-920
spellingShingle	achillea millefolium morphine pain rat Medicine R Medicine (General) R5-920 A, Arzi M Akhavan The effect of hydroalcoholic extract of Achillea Millefolium on analgesic effect of Morphine in rats
description	Objective: Achillea millefolium is a plant whose anti-inflammatory effects were proved by inhibition of cyclooxygenase enzyme activities. In this study, the effect of its hydroalcoholic extract on analgesic effect of morphine was investigated to lower the dose of injected morphine as much as possible. Methods: This study was performed on rats by tail flick test. At first a suitable dose of morphine that caused analgesia was selected by dose response method. Then analgesic effect of different doses of achillea millefolium extract (25, 50, 75 and 100 mg/kg) and also the effect of these doses on analgesic effect of a suitable dose of morphine (2.5 mg/kg) were investigated. Findings: According to the results and by using analytical variance method, the best dose of extract selected for improving the analgesic effect of morphine was 75 mg/kg (P<0.05). Reflex time in control group to alogenic stimulant was about 2-3 seconds and in rats, which received different doses of hydroalcoholic, extract of achillea millefolium before injection of morphine (2.5 mg/kg) in comparison to those which only received morphine showed a significant increase (P<0.05). Conclusion: All doses of hydroalcoholic extract of achillea millefolium caused an increase of analgesic effect of morphine significantly (P<0.05). Meanwhile, the strongest effect was observed at 45th minute of the trial.
format	article
author	A, Arzi M Akhavan
author_facet	A, Arzi M Akhavan
author_sort	A, Arzi
title	The effect of hydroalcoholic extract of Achillea Millefolium on analgesic effect of Morphine in rats
title_short	The effect of hydroalcoholic extract of Achillea Millefolium on analgesic effect of Morphine in rats
title_full	The effect of hydroalcoholic extract of Achillea Millefolium on analgesic effect of Morphine in rats
title_fullStr	The effect of hydroalcoholic extract of Achillea Millefolium on analgesic effect of Morphine in rats
title_full_unstemmed	The effect of hydroalcoholic extract of Achillea Millefolium on analgesic effect of Morphine in rats
title_sort	effect of hydroalcoholic extract of achillea millefolium on analgesic effect of morphine in rats
publisher	Babol University of Medical Sciences
publishDate	2001
url	https://doaj.org/article/7b5d4d7ec7bb41f2be7202de4e4295e2
work_keys_str_mv	AT aarzi theeffectofhydroalcoholicextractofachilleamillefoliumonanalgesiceffectofmorphineinrats AT makhavan theeffectofhydroalcoholicextractofachilleamillefoliumonanalgesiceffectofmorphineinrats AT aarzi effectofhydroalcoholicextractofachilleamillefoliumonanalgesiceffectofmorphineinrats AT makhavan effectofhydroalcoholicextractofachilleamillefoliumonanalgesiceffectofmorphineinrats
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The effect of hydroalcoholic extract of Achillea Millefolium on analgesic effect of Morphine in rats

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