Differences in immune status and fecal SCFA between Indonesian stunted children and children with normal nutritional status.

We recently showed that the gut microbiota composition of stunted children was different from that of children with normal nutritional status. Here, we compared immune status and fecal microbial metabolite concentrations between stunted and normal children, and we correlated macronutrient intake (in...

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Autores principales:	Ingrid S Surono, Fasli Jalal, Syukrini Bahri, Andreas Romulo, Pratiwi Dyah Kusumo, Erida Manalu, Yusnita, Koen Venema
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7b61902ada3548d784279e2f71c46d80
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spelling	oai:doaj.org-article:7b61902ada3548d784279e2f71c46d802021-12-02T20:09:00ZDifferences in immune status and fecal SCFA between Indonesian stunted children and children with normal nutritional status.1932-620310.1371/journal.pone.0254300https://doaj.org/article/7b61902ada3548d784279e2f71c46d802021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254300https://doaj.org/toc/1932-6203We recently showed that the gut microbiota composition of stunted children was different from that of children with normal nutritional status. Here, we compared immune status and fecal microbial metabolite concentrations between stunted and normal children, and we correlated macronutrient intake (including energy), metabolites and immune status to microbiota composition. The results show that macronutrient intake was lower in stunted children for all components, but after correction for multiple comparison significant only for energy and fat. Only TGF-β was significantly different between stunted children and children of normal nutritional status after correction for multiple comparisons. TNF-alpha, IL-10, lipopolysaccharide binding protein in serum and secretory IgA in feces were not significantly different. Strikingly, all the individual short-chain and branched-chain fatty acids were higher in fecal samples of stunted children (significant for acetate, valerate and total SCFA). These metabolites correlated with a number of different microbial taxa, but due to extensive cross-feeding between microbes, did not show a specific pattern. However, the energy-loss due to higher excretion in stunted children of these metabolites, which can be used as substrate for the host, is striking. Several microbial taxa also correlated to the intake of macronutrients (including dietary fibre) and energy. Eisenbergiella positively correlated with all macronutrients, while an uncharacterized genus within the Succinivibrionaceae family negatively correlated with all macronutrients. These, and the other correlations observed, may provide indication on how to modulate the gut microbiota of stunted children such that their growth lag can be corrected. Trail registered at https://clinicaltrials.gov/ct2/show/NCT04698759.Ingrid S SuronoFasli JalalSyukrini BahriAndreas RomuloPratiwi Dyah KusumoErida ManaluYusnitaKoen VenemaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254300 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ingrid S Surono Fasli Jalal Syukrini Bahri Andreas Romulo Pratiwi Dyah Kusumo Erida Manalu Yusnita Koen Venema Differences in immune status and fecal SCFA between Indonesian stunted children and children with normal nutritional status.
description	We recently showed that the gut microbiota composition of stunted children was different from that of children with normal nutritional status. Here, we compared immune status and fecal microbial metabolite concentrations between stunted and normal children, and we correlated macronutrient intake (including energy), metabolites and immune status to microbiota composition. The results show that macronutrient intake was lower in stunted children for all components, but after correction for multiple comparison significant only for energy and fat. Only TGF-β was significantly different between stunted children and children of normal nutritional status after correction for multiple comparisons. TNF-alpha, IL-10, lipopolysaccharide binding protein in serum and secretory IgA in feces were not significantly different. Strikingly, all the individual short-chain and branched-chain fatty acids were higher in fecal samples of stunted children (significant for acetate, valerate and total SCFA). These metabolites correlated with a number of different microbial taxa, but due to extensive cross-feeding between microbes, did not show a specific pattern. However, the energy-loss due to higher excretion in stunted children of these metabolites, which can be used as substrate for the host, is striking. Several microbial taxa also correlated to the intake of macronutrients (including dietary fibre) and energy. Eisenbergiella positively correlated with all macronutrients, while an uncharacterized genus within the Succinivibrionaceae family negatively correlated with all macronutrients. These, and the other correlations observed, may provide indication on how to modulate the gut microbiota of stunted children such that their growth lag can be corrected. Trail registered at https://clinicaltrials.gov/ct2/show/NCT04698759.
format	article
author	Ingrid S Surono Fasli Jalal Syukrini Bahri Andreas Romulo Pratiwi Dyah Kusumo Erida Manalu Yusnita Koen Venema
author_facet	Ingrid S Surono Fasli Jalal Syukrini Bahri Andreas Romulo Pratiwi Dyah Kusumo Erida Manalu Yusnita Koen Venema
author_sort	Ingrid S Surono
title	Differences in immune status and fecal SCFA between Indonesian stunted children and children with normal nutritional status.
title_short	Differences in immune status and fecal SCFA between Indonesian stunted children and children with normal nutritional status.
title_full	Differences in immune status and fecal SCFA between Indonesian stunted children and children with normal nutritional status.
title_fullStr	Differences in immune status and fecal SCFA between Indonesian stunted children and children with normal nutritional status.
title_full_unstemmed	Differences in immune status and fecal SCFA between Indonesian stunted children and children with normal nutritional status.
title_sort	differences in immune status and fecal scfa between indonesian stunted children and children with normal nutritional status.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/7b61902ada3548d784279e2f71c46d80
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Differences in immune status and fecal SCFA between Indonesian stunted children and children with normal nutritional status.

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