Toll-like receptor 4 mediates endothelial cell activation through NF-κB but is not associated with endothelial dysfunction in patients with rheumatoid arthritis.

Toll-like receptor 4 mediates endothelial cell activation through NF-κB but is not associated with endothelial dysfunction in patients with rheumatoid arthritis.

<h4>Objective</h4>To investigate the effects of TLR4 antagonism on human endothelial cells activation and cytokine expression, and whether the Asp299Gly TLR4 polymorphism is associated with better endothelial function in patients with rheumatoid arthritis (RA).<h4>Methods</h4>...

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Main Authors: Rossella Menghini, Umberto Campia, Manfredi Tesauro, Arianna Marino, Valentina Rovella, Giuseppe Rodia, Francesca Schinzari, Barbara Tolusso, Nicola di Daniele, Massimo Federici, Angelo Zoli, Gianfranco Ferraccioli, Carmine Cardillo
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2014
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/7b64eb30c17443a592e3cd20aca7cb05
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