Functional connectivity and upper limb function in patients after pediatric arterial ischemic stroke with contralateral corticospinal tract wiring

Abstract To develop individualized motor rehabilitation, knowledge of the relationship between neuroplastic reorganization and motor recovery after pediatric arterial ischemic stroke (AIS) is crucial. Thus, we investigated functional connectivity in patients after AIS with good motor outcome and in...

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Autores principales:	Leonie Steiner, Stephanie Homan, Regula Everts, Andrea Federspiel, Sandeep Kamal, Juan Antonio Delgado Rodriguez, Salome Kornfeld, Nedelina Slavova, Roland Wiest, Alain Kaelin-Lang, Maja Steinlin, Sebastian Grunt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7b656ee2de6b4668bca2ac76f71cec08
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spelling	oai:doaj.org-article:7b656ee2de6b4668bca2ac76f71cec082021-12-02T13:19:28ZFunctional connectivity and upper limb function in patients after pediatric arterial ischemic stroke with contralateral corticospinal tract wiring10.1038/s41598-021-84671-22045-2322https://doaj.org/article/7b656ee2de6b4668bca2ac76f71cec082021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84671-2https://doaj.org/toc/2045-2322Abstract To develop individualized motor rehabilitation, knowledge of the relationship between neuroplastic reorganization and motor recovery after pediatric arterial ischemic stroke (AIS) is crucial. Thus, we investigated functional connectivity in patients after AIS with good motor outcome and in patients with hemiparesis compared with typically developing peers. We included 18 patients (n = 9 with hemiparesis, n = 9 with good motor outcome) with pediatric AIS in the chronic phase (≥ 2 years after diagnosis, diagnosed > 16 years) and 18 peers matched by age and gender. Participants underwent a standardized motor assessment, single-pulse transcranial magnetic stimulation to determine the type of corticospinal tract wiring, and resting-state functional magnetic resonance imaging to examine motor network connectivity. Corticospinal tract wiring was contralateral in all participants. Patients with hemiparesis had lower interhemispheric connectivity strength compared with patients with good clinical outcome and peers. Patients with good clinical outcome had higher intrahemispheric connectivity strength compared with peers. Further, higher intrahemispheric connectivity was related to better motor outcome in patients. Our findings suggest that better motor outcome after pediatric AIS is related to higher motor network connectivity strength. Thus, resting-state functional connectivity might be predictive for motor recovery after pediatric AIS.Leonie SteinerStephanie HomanRegula EvertsAndrea FederspielSandeep KamalJuan Antonio Delgado RodriguezSalome KornfeldNedelina SlavovaRoland WiestAlain Kaelin-LangMaja SteinlinSebastian GruntNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Leonie Steiner Stephanie Homan Regula Everts Andrea Federspiel Sandeep Kamal Juan Antonio Delgado Rodriguez Salome Kornfeld Nedelina Slavova Roland Wiest Alain Kaelin-Lang Maja Steinlin Sebastian Grunt Functional connectivity and upper limb function in patients after pediatric arterial ischemic stroke with contralateral corticospinal tract wiring
description	Abstract To develop individualized motor rehabilitation, knowledge of the relationship between neuroplastic reorganization and motor recovery after pediatric arterial ischemic stroke (AIS) is crucial. Thus, we investigated functional connectivity in patients after AIS with good motor outcome and in patients with hemiparesis compared with typically developing peers. We included 18 patients (n = 9 with hemiparesis, n = 9 with good motor outcome) with pediatric AIS in the chronic phase (≥ 2 years after diagnosis, diagnosed > 16 years) and 18 peers matched by age and gender. Participants underwent a standardized motor assessment, single-pulse transcranial magnetic stimulation to determine the type of corticospinal tract wiring, and resting-state functional magnetic resonance imaging to examine motor network connectivity. Corticospinal tract wiring was contralateral in all participants. Patients with hemiparesis had lower interhemispheric connectivity strength compared with patients with good clinical outcome and peers. Patients with good clinical outcome had higher intrahemispheric connectivity strength compared with peers. Further, higher intrahemispheric connectivity was related to better motor outcome in patients. Our findings suggest that better motor outcome after pediatric AIS is related to higher motor network connectivity strength. Thus, resting-state functional connectivity might be predictive for motor recovery after pediatric AIS.
format	article
author	Leonie Steiner Stephanie Homan Regula Everts Andrea Federspiel Sandeep Kamal Juan Antonio Delgado Rodriguez Salome Kornfeld Nedelina Slavova Roland Wiest Alain Kaelin-Lang Maja Steinlin Sebastian Grunt
author_facet	Leonie Steiner Stephanie Homan Regula Everts Andrea Federspiel Sandeep Kamal Juan Antonio Delgado Rodriguez Salome Kornfeld Nedelina Slavova Roland Wiest Alain Kaelin-Lang Maja Steinlin Sebastian Grunt
author_sort	Leonie Steiner
title	Functional connectivity and upper limb function in patients after pediatric arterial ischemic stroke with contralateral corticospinal tract wiring
title_short	Functional connectivity and upper limb function in patients after pediatric arterial ischemic stroke with contralateral corticospinal tract wiring
title_full	Functional connectivity and upper limb function in patients after pediatric arterial ischemic stroke with contralateral corticospinal tract wiring
title_fullStr	Functional connectivity and upper limb function in patients after pediatric arterial ischemic stroke with contralateral corticospinal tract wiring
title_full_unstemmed	Functional connectivity and upper limb function in patients after pediatric arterial ischemic stroke with contralateral corticospinal tract wiring
title_sort	functional connectivity and upper limb function in patients after pediatric arterial ischemic stroke with contralateral corticospinal tract wiring
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7b656ee2de6b4668bca2ac76f71cec08
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Functional connectivity and upper limb function in patients after pediatric arterial ischemic stroke with contralateral corticospinal tract wiring

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