Preventing acute asthmatic symptoms by targeting a neuronal mechanism involving carotid body lysophosphatidic acid receptors

Preventing acute asthmatic symptoms by targeting a neuronal mechanism involving carotid body lysophosphatidic acid receptors

Acute bronchoconstriction is the leading cause of asthmatic sudden death following allergen exposure. The authors show that the systemic increase of LPA following inhaled allergen or bradykinin challenge activates the carotid bodies through TRPV1 and LPA-specific receptors and that systemic TRPV1 an...

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Auteurs principaux: Nicholas G. Jendzjowsky, Arijit Roy, Nicole O. Barioni, Margaret M. Kelly, Francis H. Y. Green, Christopher N. Wyatt, Richard L. Pye, Luana Tenorio-Lopes, Richard J. A. Wilson
Format: article
Langue:EN
Publié: Nature Portfolio 2018
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Science
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Accès en ligne:https://doaj.org/article/7b65eae4fc874352ad6f95844a3997d9
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Résumé:Acute bronchoconstriction is the leading cause of asthmatic sudden death following allergen exposure. The authors show that the systemic increase of LPA following inhaled allergen or bradykinin challenge activates the carotid bodies through TRPV1 and LPA-specific receptors and that systemic TRPV1 and LPA-specific receptor antagonists ameliorate acute bronchoconstriction.

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