Preventing acute asthmatic symptoms by targeting a neuronal mechanism involving carotid body lysophosphatidic acid receptors

Acute bronchoconstriction is the leading cause of asthmatic sudden death following allergen exposure. The authors show that the systemic increase of LPA following inhaled allergen or bradykinin challenge activates the carotid bodies through TRPV1 and LPA-specific receptors and that systemic TRPV1 an...

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Autores principales:	Nicholas G. Jendzjowsky, Arijit Roy, Nicole O. Barioni, Margaret M. Kelly, Francis H. Y. Green, Christopher N. Wyatt, Richard L. Pye, Luana Tenorio-Lopes, Richard J. A. Wilson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7b65eae4fc874352ad6f95844a3997d9
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spelling	oai:doaj.org-article:7b65eae4fc874352ad6f95844a3997d92021-12-02T15:34:26ZPreventing acute asthmatic symptoms by targeting a neuronal mechanism involving carotid body lysophosphatidic acid receptors10.1038/s41467-018-06189-y2041-1723https://doaj.org/article/7b65eae4fc874352ad6f95844a3997d92018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06189-yhttps://doaj.org/toc/2041-1723Acute bronchoconstriction is the leading cause of asthmatic sudden death following allergen exposure. The authors show that the systemic increase of LPA following inhaled allergen or bradykinin challenge activates the carotid bodies through TRPV1 and LPA-specific receptors and that systemic TRPV1 and LPA-specific receptor antagonists ameliorate acute bronchoconstriction.Nicholas G. JendzjowskyArijit RoyNicole O. BarioniMargaret M. KellyFrancis H. Y. GreenChristopher N. WyattRichard L. PyeLuana Tenorio-LopesRichard J. A. WilsonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicholas G. Jendzjowsky Arijit Roy Nicole O. Barioni Margaret M. Kelly Francis H. Y. Green Christopher N. Wyatt Richard L. Pye Luana Tenorio-Lopes Richard J. A. Wilson Preventing acute asthmatic symptoms by targeting a neuronal mechanism involving carotid body lysophosphatidic acid receptors
description	Acute bronchoconstriction is the leading cause of asthmatic sudden death following allergen exposure. The authors show that the systemic increase of LPA following inhaled allergen or bradykinin challenge activates the carotid bodies through TRPV1 and LPA-specific receptors and that systemic TRPV1 and LPA-specific receptor antagonists ameliorate acute bronchoconstriction.
format	article
author	Nicholas G. Jendzjowsky Arijit Roy Nicole O. Barioni Margaret M. Kelly Francis H. Y. Green Christopher N. Wyatt Richard L. Pye Luana Tenorio-Lopes Richard J. A. Wilson
author_facet	Nicholas G. Jendzjowsky Arijit Roy Nicole O. Barioni Margaret M. Kelly Francis H. Y. Green Christopher N. Wyatt Richard L. Pye Luana Tenorio-Lopes Richard J. A. Wilson
author_sort	Nicholas G. Jendzjowsky
title	Preventing acute asthmatic symptoms by targeting a neuronal mechanism involving carotid body lysophosphatidic acid receptors
title_short	Preventing acute asthmatic symptoms by targeting a neuronal mechanism involving carotid body lysophosphatidic acid receptors
title_full	Preventing acute asthmatic symptoms by targeting a neuronal mechanism involving carotid body lysophosphatidic acid receptors
title_fullStr	Preventing acute asthmatic symptoms by targeting a neuronal mechanism involving carotid body lysophosphatidic acid receptors
title_full_unstemmed	Preventing acute asthmatic symptoms by targeting a neuronal mechanism involving carotid body lysophosphatidic acid receptors
title_sort	preventing acute asthmatic symptoms by targeting a neuronal mechanism involving carotid body lysophosphatidic acid receptors
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7b65eae4fc874352ad6f95844a3997d9
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Preventing acute asthmatic symptoms by targeting a neuronal mechanism involving carotid body lysophosphatidic acid receptors

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