Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF

Small molecules stabilising a distorted TNF trimer can inhibit TNF signaling, but the underlying mechanism is unclear. Here, the authors characterize the inhibitor-bound TNF-receptor complex structurally and biochemically, showing that the inhibitors alter TNF-receptor binding stoichiometry and clus...

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Autores principales:	David McMillan, Carlos Martinez-Fleites, John Porter, David Fox, Rachel Davis, Prashant Mori, Tom Ceska, Bruce Carrington, Alastair Lawson, Tim Bourne, James O’Connell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7b680bc50b1f4b8588a84e2e0adb588a
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spelling	oai:doaj.org-article:7b680bc50b1f4b8588a84e2e0adb588a2021-12-02T14:16:13ZStructural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF10.1038/s41467-020-20828-32041-1723https://doaj.org/article/7b680bc50b1f4b8588a84e2e0adb588a2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20828-3https://doaj.org/toc/2041-1723Small molecules stabilising a distorted TNF trimer can inhibit TNF signaling, but the underlying mechanism is unclear. Here, the authors characterize the inhibitor-bound TNF-receptor complex structurally and biochemically, showing that the inhibitors alter TNF-receptor binding stoichiometry and cluster formation.David McMillanCarlos Martinez-FleitesJohn PorterDavid FoxRachel DavisPrashant MoriTom CeskaBruce CarringtonAlastair LawsonTim BourneJames O’ConnellNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David McMillan Carlos Martinez-Fleites John Porter David Fox Rachel Davis Prashant Mori Tom Ceska Bruce Carrington Alastair Lawson Tim Bourne James O’Connell Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF
description	Small molecules stabilising a distorted TNF trimer can inhibit TNF signaling, but the underlying mechanism is unclear. Here, the authors characterize the inhibitor-bound TNF-receptor complex structurally and biochemically, showing that the inhibitors alter TNF-receptor binding stoichiometry and cluster formation.
format	article
author	David McMillan Carlos Martinez-Fleites John Porter David Fox Rachel Davis Prashant Mori Tom Ceska Bruce Carrington Alastair Lawson Tim Bourne James O’Connell
author_facet	David McMillan Carlos Martinez-Fleites John Porter David Fox Rachel Davis Prashant Mori Tom Ceska Bruce Carrington Alastair Lawson Tim Bourne James O’Connell
author_sort	David McMillan
title	Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF
title_short	Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF
title_full	Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF
title_fullStr	Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF
title_full_unstemmed	Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF
title_sort	structural insights into the disruption of tnf-tnfr1 signalling by small molecules stabilising a distorted tnf
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7b680bc50b1f4b8588a84e2e0adb588a
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Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF

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