Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF

Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF

Small molecules stabilising a distorted TNF trimer can inhibit TNF signaling, but the underlying mechanism is unclear. Here, the authors characterize the inhibitor-bound TNF-receptor complex structurally and biochemically, showing that the inhibitors alter TNF-receptor binding stoichiometry and clus...

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Autores principales: David McMillan, Carlos Martinez-Fleites, John Porter, David Fox, Rachel Davis, Prashant Mori, Tom Ceska, Bruce Carrington, Alastair Lawson, Tim Bourne, James O’Connell
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/7b680bc50b1f4b8588a84e2e0adb588a
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