Low serum adiponectin level is associated with better physical health-related quality of life in chronic kidney disease

Abstract Hyperadiponectemia is paradoxically associated with renal disease progression and mortality in chronic kidney disease (CKD). Its association with health-related quality of life (HR-QOL) is unknown. This study aimed to verify the association between adiponectin and HR-QOL in Korean pre-dialy...

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Autores principales:	Ji Hye Kim, Ji Min Han, Hyang Kim, Kyu-Beck Lee, Wookyung Chung, Yong-Soo Kim, Sue K. Park, Dong Wan Chae, Curie Ahn, Kook-Hwan Oh, Young Youl Hyun, KNOW-CKD Study Group
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7b755fa98ad5488cb404f7f69c11ff8d
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spelling	oai:doaj.org-article:7b755fa98ad5488cb404f7f69c11ff8d2021-12-02T14:42:01ZLow serum adiponectin level is associated with better physical health-related quality of life in chronic kidney disease10.1038/s41598-021-90339-82045-2322https://doaj.org/article/7b755fa98ad5488cb404f7f69c11ff8d2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90339-8https://doaj.org/toc/2045-2322Abstract Hyperadiponectemia is paradoxically associated with renal disease progression and mortality in chronic kidney disease (CKD). Its association with health-related quality of life (HR-QOL) is unknown. This study aimed to verify the association between adiponectin and HR-QOL in Korean pre-dialysis CKD cohort. This cross-sectional study analyzed 1551 pre-dialysis CKD patients from KNOW-CKD (KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease). Participants were categorized into three tertiles (T1–T3) according to adiponectin levels. HR-QOL was assessed using SF-36. High physical component summary (PCS) and mental component summary (MCS) were defined as highest quartile of each score. Multivariate logistic regression was used to analyze odds ratio (OR) and 95% confidence interval (CI) for high PCS and MCS. Prevalence of high PCS were 33.3%, 27.5%, and 17.0% and that of high MCS were 31.7%, 24.8%, and 21.3% for T1, T2, and T3 (both p for trend < 0.001). The adjusted OR [95% CI] of T1 and T2 in reference to T3 were 1.56 [1.09–2.23] and 1.19 [0.85–1.68] for high PCS and 1.19 [0.85–1.68] and 0.94 [0.68–1.29] for high MCS. Serum adiponectin level was inversely associated with physical HR-QOL in Korean pre-dialysis CKD patients. This relationship was independent of various cardiovascular risk factors.Ji Hye KimJi Min HanHyang KimKyu-Beck LeeWookyung ChungYong-Soo KimSue K. ParkDong Wan ChaeCurie AhnKook-Hwan OhYoung Youl HyunKNOW-CKD Study GroupNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ji Hye Kim Ji Min Han Hyang Kim Kyu-Beck Lee Wookyung Chung Yong-Soo Kim Sue K. Park Dong Wan Chae Curie Ahn Kook-Hwan Oh Young Youl Hyun KNOW-CKD Study Group Low serum adiponectin level is associated with better physical health-related quality of life in chronic kidney disease
description	Abstract Hyperadiponectemia is paradoxically associated with renal disease progression and mortality in chronic kidney disease (CKD). Its association with health-related quality of life (HR-QOL) is unknown. This study aimed to verify the association between adiponectin and HR-QOL in Korean pre-dialysis CKD cohort. This cross-sectional study analyzed 1551 pre-dialysis CKD patients from KNOW-CKD (KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease). Participants were categorized into three tertiles (T1–T3) according to adiponectin levels. HR-QOL was assessed using SF-36. High physical component summary (PCS) and mental component summary (MCS) were defined as highest quartile of each score. Multivariate logistic regression was used to analyze odds ratio (OR) and 95% confidence interval (CI) for high PCS and MCS. Prevalence of high PCS were 33.3%, 27.5%, and 17.0% and that of high MCS were 31.7%, 24.8%, and 21.3% for T1, T2, and T3 (both p for trend < 0.001). The adjusted OR [95% CI] of T1 and T2 in reference to T3 were 1.56 [1.09–2.23] and 1.19 [0.85–1.68] for high PCS and 1.19 [0.85–1.68] and 0.94 [0.68–1.29] for high MCS. Serum adiponectin level was inversely associated with physical HR-QOL in Korean pre-dialysis CKD patients. This relationship was independent of various cardiovascular risk factors.
format	article
author	Ji Hye Kim Ji Min Han Hyang Kim Kyu-Beck Lee Wookyung Chung Yong-Soo Kim Sue K. Park Dong Wan Chae Curie Ahn Kook-Hwan Oh Young Youl Hyun KNOW-CKD Study Group
author_facet	Ji Hye Kim Ji Min Han Hyang Kim Kyu-Beck Lee Wookyung Chung Yong-Soo Kim Sue K. Park Dong Wan Chae Curie Ahn Kook-Hwan Oh Young Youl Hyun KNOW-CKD Study Group
author_sort	Ji Hye Kim
title	Low serum adiponectin level is associated with better physical health-related quality of life in chronic kidney disease
title_short	Low serum adiponectin level is associated with better physical health-related quality of life in chronic kidney disease
title_full	Low serum adiponectin level is associated with better physical health-related quality of life in chronic kidney disease
title_fullStr	Low serum adiponectin level is associated with better physical health-related quality of life in chronic kidney disease
title_full_unstemmed	Low serum adiponectin level is associated with better physical health-related quality of life in chronic kidney disease
title_sort	low serum adiponectin level is associated with better physical health-related quality of life in chronic kidney disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7b755fa98ad5488cb404f7f69c11ff8d
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Low serum adiponectin level is associated with better physical health-related quality of life in chronic kidney disease

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