Elevated serum ferritin level is associated with the incident type 2 diabetes in healthy Korean men: a 4 year longitudinal study.
<h4>Background</h4>Elevated ferritin concentration has been implicated in the etiology of type 2 diabetes. Accumulating evidence, mostly from studies conducted on western populations, has demonstrated a strong association between the elevated ferritin concentrations and incident type 2 d...
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oai:doaj.org-article:7b7770d821f549d88e8e630132413bb32021-11-18T08:53:09ZElevated serum ferritin level is associated with the incident type 2 diabetes in healthy Korean men: a 4 year longitudinal study.1932-620310.1371/journal.pone.0075250https://doaj.org/article/7b7770d821f549d88e8e630132413bb32013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24098686/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Elevated ferritin concentration has been implicated in the etiology of type 2 diabetes. Accumulating evidence, mostly from studies conducted on western populations, has demonstrated a strong association between the elevated ferritin concentrations and incident type 2 diabetes. In Asian populations, however, the longitudinal studies investigating the association of elevated serum ferritin levels and type 2 diabetes are lacking. In present study, we aimed to determine whether elevated serum ferritin levels are related to the incident type 2 diabetes in healthy Korean men.<h4>Methodology/principal findings</h4>This 4 year longitudinal observational study was conducted at the Asan Medical Center, Seoul, Republic of Korea. The study population consisted of 2,029 men without type 2 diabetes who underwent routine health examination in 2007 (baseline) and 2011 (follow-up). Baseline serum ferritin concentrations were measured by chemiluminescent two-site sandwich immunoassay. In multiple-adjusted model, the relative risk (RR) for incident type 2 diabetes was significantly higher in highest compared with the lowest ferritin quartile category, even after adjusting for confounding variables including homeostasis model assessment of insulin resistance (RR = 2.17, 95% confidence interval 1.27-3.72, P for trend = 0.013).<h4>Conclusions/significance</h4>These results demonstrated that elevated level of serum ferritin at baseline was associated with incident type 2 diabetes in an Asian population.Chang Hee JungMin Jung LeeJenie Yoonoo HwangJung Eun JangJaechan LeemJoong-Yeol ParkJungBok LeeHong-Kyu KimWoo Je LeePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e75250 (2013) |
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Medicine R Science Q Chang Hee Jung Min Jung Lee Jenie Yoonoo Hwang Jung Eun Jang Jaechan Leem Joong-Yeol Park JungBok Lee Hong-Kyu Kim Woo Je Lee Elevated serum ferritin level is associated with the incident type 2 diabetes in healthy Korean men: a 4 year longitudinal study. |
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<h4>Background</h4>Elevated ferritin concentration has been implicated in the etiology of type 2 diabetes. Accumulating evidence, mostly from studies conducted on western populations, has demonstrated a strong association between the elevated ferritin concentrations and incident type 2 diabetes. In Asian populations, however, the longitudinal studies investigating the association of elevated serum ferritin levels and type 2 diabetes are lacking. In present study, we aimed to determine whether elevated serum ferritin levels are related to the incident type 2 diabetes in healthy Korean men.<h4>Methodology/principal findings</h4>This 4 year longitudinal observational study was conducted at the Asan Medical Center, Seoul, Republic of Korea. The study population consisted of 2,029 men without type 2 diabetes who underwent routine health examination in 2007 (baseline) and 2011 (follow-up). Baseline serum ferritin concentrations were measured by chemiluminescent two-site sandwich immunoassay. In multiple-adjusted model, the relative risk (RR) for incident type 2 diabetes was significantly higher in highest compared with the lowest ferritin quartile category, even after adjusting for confounding variables including homeostasis model assessment of insulin resistance (RR = 2.17, 95% confidence interval 1.27-3.72, P for trend = 0.013).<h4>Conclusions/significance</h4>These results demonstrated that elevated level of serum ferritin at baseline was associated with incident type 2 diabetes in an Asian population. |
format |
article |
author |
Chang Hee Jung Min Jung Lee Jenie Yoonoo Hwang Jung Eun Jang Jaechan Leem Joong-Yeol Park JungBok Lee Hong-Kyu Kim Woo Je Lee |
author_facet |
Chang Hee Jung Min Jung Lee Jenie Yoonoo Hwang Jung Eun Jang Jaechan Leem Joong-Yeol Park JungBok Lee Hong-Kyu Kim Woo Je Lee |
author_sort |
Chang Hee Jung |
title |
Elevated serum ferritin level is associated with the incident type 2 diabetes in healthy Korean men: a 4 year longitudinal study. |
title_short |
Elevated serum ferritin level is associated with the incident type 2 diabetes in healthy Korean men: a 4 year longitudinal study. |
title_full |
Elevated serum ferritin level is associated with the incident type 2 diabetes in healthy Korean men: a 4 year longitudinal study. |
title_fullStr |
Elevated serum ferritin level is associated with the incident type 2 diabetes in healthy Korean men: a 4 year longitudinal study. |
title_full_unstemmed |
Elevated serum ferritin level is associated with the incident type 2 diabetes in healthy Korean men: a 4 year longitudinal study. |
title_sort |
elevated serum ferritin level is associated with the incident type 2 diabetes in healthy korean men: a 4 year longitudinal study. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2013 |
url |
https://doaj.org/article/7b7770d821f549d88e8e630132413bb3 |
work_keys_str_mv |
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