Elevated serum ferritin level is associated with the incident type 2 diabetes in healthy Korean men: a 4 year longitudinal study.

<h4>Background</h4>Elevated ferritin concentration has been implicated in the etiology of type 2 diabetes. Accumulating evidence, mostly from studies conducted on western populations, has demonstrated a strong association between the elevated ferritin concentrations and incident type 2 d...

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Autores principales: Chang Hee Jung, Min Jung Lee, Jenie Yoonoo Hwang, Jung Eun Jang, Jaechan Leem, Joong-Yeol Park, JungBok Lee, Hong-Kyu Kim, Woo Je Lee
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Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/7b7770d821f549d88e8e630132413bb3
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spelling oai:doaj.org-article:7b7770d821f549d88e8e630132413bb32021-11-18T08:53:09ZElevated serum ferritin level is associated with the incident type 2 diabetes in healthy Korean men: a 4 year longitudinal study.1932-620310.1371/journal.pone.0075250https://doaj.org/article/7b7770d821f549d88e8e630132413bb32013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24098686/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Elevated ferritin concentration has been implicated in the etiology of type 2 diabetes. Accumulating evidence, mostly from studies conducted on western populations, has demonstrated a strong association between the elevated ferritin concentrations and incident type 2 diabetes. In Asian populations, however, the longitudinal studies investigating the association of elevated serum ferritin levels and type 2 diabetes are lacking. In present study, we aimed to determine whether elevated serum ferritin levels are related to the incident type 2 diabetes in healthy Korean men.<h4>Methodology/principal findings</h4>This 4 year longitudinal observational study was conducted at the Asan Medical Center, Seoul, Republic of Korea. The study population consisted of 2,029 men without type 2 diabetes who underwent routine health examination in 2007 (baseline) and 2011 (follow-up). Baseline serum ferritin concentrations were measured by chemiluminescent two-site sandwich immunoassay. In multiple-adjusted model, the relative risk (RR) for incident type 2 diabetes was significantly higher in highest compared with the lowest ferritin quartile category, even after adjusting for confounding variables including homeostasis model assessment of insulin resistance (RR = 2.17, 95% confidence interval 1.27-3.72, P for trend = 0.013).<h4>Conclusions/significance</h4>These results demonstrated that elevated level of serum ferritin at baseline was associated with incident type 2 diabetes in an Asian population.Chang Hee JungMin Jung LeeJenie Yoonoo HwangJung Eun JangJaechan LeemJoong-Yeol ParkJungBok LeeHong-Kyu KimWoo Je LeePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e75250 (2013)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Chang Hee Jung
Min Jung Lee
Jenie Yoonoo Hwang
Jung Eun Jang
Jaechan Leem
Joong-Yeol Park
JungBok Lee
Hong-Kyu Kim
Woo Je Lee
Elevated serum ferritin level is associated with the incident type 2 diabetes in healthy Korean men: a 4 year longitudinal study.
description <h4>Background</h4>Elevated ferritin concentration has been implicated in the etiology of type 2 diabetes. Accumulating evidence, mostly from studies conducted on western populations, has demonstrated a strong association between the elevated ferritin concentrations and incident type 2 diabetes. In Asian populations, however, the longitudinal studies investigating the association of elevated serum ferritin levels and type 2 diabetes are lacking. In present study, we aimed to determine whether elevated serum ferritin levels are related to the incident type 2 diabetes in healthy Korean men.<h4>Methodology/principal findings</h4>This 4 year longitudinal observational study was conducted at the Asan Medical Center, Seoul, Republic of Korea. The study population consisted of 2,029 men without type 2 diabetes who underwent routine health examination in 2007 (baseline) and 2011 (follow-up). Baseline serum ferritin concentrations were measured by chemiluminescent two-site sandwich immunoassay. In multiple-adjusted model, the relative risk (RR) for incident type 2 diabetes was significantly higher in highest compared with the lowest ferritin quartile category, even after adjusting for confounding variables including homeostasis model assessment of insulin resistance (RR = 2.17, 95% confidence interval 1.27-3.72, P for trend = 0.013).<h4>Conclusions/significance</h4>These results demonstrated that elevated level of serum ferritin at baseline was associated with incident type 2 diabetes in an Asian population.
format article
author Chang Hee Jung
Min Jung Lee
Jenie Yoonoo Hwang
Jung Eun Jang
Jaechan Leem
Joong-Yeol Park
JungBok Lee
Hong-Kyu Kim
Woo Je Lee
author_facet Chang Hee Jung
Min Jung Lee
Jenie Yoonoo Hwang
Jung Eun Jang
Jaechan Leem
Joong-Yeol Park
JungBok Lee
Hong-Kyu Kim
Woo Je Lee
author_sort Chang Hee Jung
title Elevated serum ferritin level is associated with the incident type 2 diabetes in healthy Korean men: a 4 year longitudinal study.
title_short Elevated serum ferritin level is associated with the incident type 2 diabetes in healthy Korean men: a 4 year longitudinal study.
title_full Elevated serum ferritin level is associated with the incident type 2 diabetes in healthy Korean men: a 4 year longitudinal study.
title_fullStr Elevated serum ferritin level is associated with the incident type 2 diabetes in healthy Korean men: a 4 year longitudinal study.
title_full_unstemmed Elevated serum ferritin level is associated with the incident type 2 diabetes in healthy Korean men: a 4 year longitudinal study.
title_sort elevated serum ferritin level is associated with the incident type 2 diabetes in healthy korean men: a 4 year longitudinal study.
publisher Public Library of Science (PLoS)
publishDate 2013
url https://doaj.org/article/7b7770d821f549d88e8e630132413bb3
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