HE DEPENDENCE OF IMMUNOGLOBULIN IGA AND IGE TEAR LEVELS FROM GLUTATHIONES-TRANSFERASE P1 GENE POLYMORPHISMS IN STEELWORKERS WITH OPHTHALMOPATHY

Abstract.  Associations  between  I105V  and  A114V gene  polymorphisms  of  glutathione-S-transferase P1  and  levels  of  IgE  and  secretory  IgA  in  tear  fluid were  studied  in  steelworkers  with  or  without  ocular diseases,  as  compared  with  healthy  office  employees. Genotyping was p...

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Autores principales: N. V. Mal’tseva, O. F. Lykova, M. A. Mel’nichenko, S. V. Arkhipova, A. L. Onishchenko
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Lenguaje:RU
Publicado: SPb RAACI 2014
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Acceso en línea:https://doaj.org/article/7b7853b3942445ad80b249bbf56761f5
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spelling oai:doaj.org-article:7b7853b3942445ad80b249bbf56761f52021-11-18T08:03:42ZHE DEPENDENCE OF IMMUNOGLOBULIN IGA AND IGE TEAR LEVELS FROM GLUTATHIONES-TRANSFERASE P1 GENE POLYMORPHISMS IN STEELWORKERS WITH OPHTHALMOPATHY1563-06252313-741X10.15789/1563-0625-2011-6-609-616https://doaj.org/article/7b7853b3942445ad80b249bbf56761f52014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/606https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract.  Associations  between  I105V  and  A114V gene  polymorphisms  of  glutathione-S-transferase P1  and  levels  of  IgE  and  secretory  IgA  in  tear  fluid were  studied  in  steelworkers  with  or  without  ocular diseases,  as  compared  with  healthy  office  employees. Genotyping was performed by means of allele-specific polymerase chain reaction, whereas ELISA technique was used for immune testing. We have found that IgE levels in tear fluid was increased in steelworkers with dystrophic eye diseases, pinguecula/pterygium, and healthy steelworkers, in comparison with control group. This increase correlates with pinguecula/pterygium size and with their industrial employment terms. Secretory IgА levels in tears were decreased in these groups of workers, as compared with controls. Concentrations of both  immunoglobulins  in  tear  samples  depended  on  I105V  and  А114V  glutathione-S-transferase  P1  gene polymorphisms. I105V polymorphism correlated with lower concentrations of tear IgЕ in steelworkers with ocular  dystrophic  diseases  and  healthy  metallurgists.  А114V  polymorphism  is  connected  with  decreased quantities of tear IgЕ in steelworkers with ocular dystrophic diseases, as well as with the lower amounts of secretory  IgА  in  healthy  workers  and  administrative  staff.  Hence,  polymorphic  loci  I105V  and  А114V  of glutathione-S-transferase P1 gene may exert a modulatory effect upon biosynthesis of both Ig types. (Med. Immunol., 2011, vol. 13, N 6, pp 609-616)N. V. Mal’tsevaO. F. LykovaM. A. Mel’nichenkoS. V. ArkhipovaA. L. OnishchenkoSPb RAACIarticleigeigaglutathione-s-transferase p1gene polymorphismophthalmic disordersImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 13, Iss 6, Pp 609-616 (2014)
institution DOAJ
collection DOAJ
language RU
topic ige
iga
glutathione-s-transferase p1
gene polymorphism
ophthalmic disorders
Immunologic diseases. Allergy
RC581-607
spellingShingle ige
iga
glutathione-s-transferase p1
gene polymorphism
ophthalmic disorders
Immunologic diseases. Allergy
RC581-607
N. V. Mal’tseva
O. F. Lykova
M. A. Mel’nichenko
S. V. Arkhipova
A. L. Onishchenko
HE DEPENDENCE OF IMMUNOGLOBULIN IGA AND IGE TEAR LEVELS FROM GLUTATHIONES-TRANSFERASE P1 GENE POLYMORPHISMS IN STEELWORKERS WITH OPHTHALMOPATHY
description Abstract.  Associations  between  I105V  and  A114V gene  polymorphisms  of  glutathione-S-transferase P1  and  levels  of  IgE  and  secretory  IgA  in  tear  fluid were  studied  in  steelworkers  with  or  without  ocular diseases,  as  compared  with  healthy  office  employees. Genotyping was performed by means of allele-specific polymerase chain reaction, whereas ELISA technique was used for immune testing. We have found that IgE levels in tear fluid was increased in steelworkers with dystrophic eye diseases, pinguecula/pterygium, and healthy steelworkers, in comparison with control group. This increase correlates with pinguecula/pterygium size and with their industrial employment terms. Secretory IgА levels in tears were decreased in these groups of workers, as compared with controls. Concentrations of both  immunoglobulins  in  tear  samples  depended  on  I105V  and  А114V  glutathione-S-transferase  P1  gene polymorphisms. I105V polymorphism correlated with lower concentrations of tear IgЕ in steelworkers with ocular  dystrophic  diseases  and  healthy  metallurgists.  А114V  polymorphism  is  connected  with  decreased quantities of tear IgЕ in steelworkers with ocular dystrophic diseases, as well as with the lower amounts of secretory  IgА  in  healthy  workers  and  administrative  staff.  Hence,  polymorphic  loci  I105V  and  А114V  of glutathione-S-transferase P1 gene may exert a modulatory effect upon biosynthesis of both Ig types. (Med. Immunol., 2011, vol. 13, N 6, pp 609-616)
format article
author N. V. Mal’tseva
O. F. Lykova
M. A. Mel’nichenko
S. V. Arkhipova
A. L. Onishchenko
author_facet N. V. Mal’tseva
O. F. Lykova
M. A. Mel’nichenko
S. V. Arkhipova
A. L. Onishchenko
author_sort N. V. Mal’tseva
title HE DEPENDENCE OF IMMUNOGLOBULIN IGA AND IGE TEAR LEVELS FROM GLUTATHIONES-TRANSFERASE P1 GENE POLYMORPHISMS IN STEELWORKERS WITH OPHTHALMOPATHY
title_short HE DEPENDENCE OF IMMUNOGLOBULIN IGA AND IGE TEAR LEVELS FROM GLUTATHIONES-TRANSFERASE P1 GENE POLYMORPHISMS IN STEELWORKERS WITH OPHTHALMOPATHY
title_full HE DEPENDENCE OF IMMUNOGLOBULIN IGA AND IGE TEAR LEVELS FROM GLUTATHIONES-TRANSFERASE P1 GENE POLYMORPHISMS IN STEELWORKERS WITH OPHTHALMOPATHY
title_fullStr HE DEPENDENCE OF IMMUNOGLOBULIN IGA AND IGE TEAR LEVELS FROM GLUTATHIONES-TRANSFERASE P1 GENE POLYMORPHISMS IN STEELWORKERS WITH OPHTHALMOPATHY
title_full_unstemmed HE DEPENDENCE OF IMMUNOGLOBULIN IGA AND IGE TEAR LEVELS FROM GLUTATHIONES-TRANSFERASE P1 GENE POLYMORPHISMS IN STEELWORKERS WITH OPHTHALMOPATHY
title_sort he dependence of immunoglobulin iga and ige tear levels from glutathiones-transferase p1 gene polymorphisms in steelworkers with ophthalmopathy
publisher SPb RAACI
publishDate 2014
url https://doaj.org/article/7b7853b3942445ad80b249bbf56761f5
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AT svarkhipova hedependenceofimmunoglobulinigaandigetearlevelsfromglutathionestransferasep1genepolymorphismsinsteelworkerswithophthalmopathy
AT alonishchenko hedependenceofimmunoglobulinigaandigetearlevelsfromglutathionestransferasep1genepolymorphismsinsteelworkerswithophthalmopathy
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