HE DEPENDENCE OF IMMUNOGLOBULIN IGA AND IGE TEAR LEVELS FROM GLUTATHIONES-TRANSFERASE P1 GENE POLYMORPHISMS IN STEELWORKERS WITH OPHTHALMOPATHY
Abstract. Associations between I105V and A114V gene polymorphisms of glutathione-S-transferase P1 and levels of IgE and secretory IgA in tear fluid were studied in steelworkers with or without ocular diseases, as compared with healthy office employees. Genotyping was p...
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2014
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oai:doaj.org-article:7b7853b3942445ad80b249bbf56761f52021-11-18T08:03:42ZHE DEPENDENCE OF IMMUNOGLOBULIN IGA AND IGE TEAR LEVELS FROM GLUTATHIONES-TRANSFERASE P1 GENE POLYMORPHISMS IN STEELWORKERS WITH OPHTHALMOPATHY1563-06252313-741X10.15789/1563-0625-2011-6-609-616https://doaj.org/article/7b7853b3942445ad80b249bbf56761f52014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/606https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Associations between I105V and A114V gene polymorphisms of glutathione-S-transferase P1 and levels of IgE and secretory IgA in tear fluid were studied in steelworkers with or without ocular diseases, as compared with healthy office employees. Genotyping was performed by means of allele-specific polymerase chain reaction, whereas ELISA technique was used for immune testing. We have found that IgE levels in tear fluid was increased in steelworkers with dystrophic eye diseases, pinguecula/pterygium, and healthy steelworkers, in comparison with control group. This increase correlates with pinguecula/pterygium size and with their industrial employment terms. Secretory IgА levels in tears were decreased in these groups of workers, as compared with controls. Concentrations of both immunoglobulins in tear samples depended on I105V and А114V glutathione-S-transferase P1 gene polymorphisms. I105V polymorphism correlated with lower concentrations of tear IgЕ in steelworkers with ocular dystrophic diseases and healthy metallurgists. А114V polymorphism is connected with decreased quantities of tear IgЕ in steelworkers with ocular dystrophic diseases, as well as with the lower amounts of secretory IgА in healthy workers and administrative staff. Hence, polymorphic loci I105V and А114V of glutathione-S-transferase P1 gene may exert a modulatory effect upon biosynthesis of both Ig types. (Med. Immunol., 2011, vol. 13, N 6, pp 609-616)N. V. Mal’tsevaO. F. LykovaM. A. Mel’nichenkoS. V. ArkhipovaA. L. OnishchenkoSPb RAACIarticleigeigaglutathione-s-transferase p1gene polymorphismophthalmic disordersImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 13, Iss 6, Pp 609-616 (2014) |
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ige iga glutathione-s-transferase p1 gene polymorphism ophthalmic disorders Immunologic diseases. Allergy RC581-607 |
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ige iga glutathione-s-transferase p1 gene polymorphism ophthalmic disorders Immunologic diseases. Allergy RC581-607 N. V. Mal’tseva O. F. Lykova M. A. Mel’nichenko S. V. Arkhipova A. L. Onishchenko HE DEPENDENCE OF IMMUNOGLOBULIN IGA AND IGE TEAR LEVELS FROM GLUTATHIONES-TRANSFERASE P1 GENE POLYMORPHISMS IN STEELWORKERS WITH OPHTHALMOPATHY |
description |
Abstract. Associations between I105V and A114V gene polymorphisms of glutathione-S-transferase P1 and levels of IgE and secretory IgA in tear fluid were studied in steelworkers with or without ocular diseases, as compared with healthy office employees. Genotyping was performed by means of allele-specific polymerase chain reaction, whereas ELISA technique was used for immune testing. We have found that IgE levels in tear fluid was increased in steelworkers with dystrophic eye diseases, pinguecula/pterygium, and healthy steelworkers, in comparison with control group. This increase correlates with pinguecula/pterygium size and with their industrial employment terms. Secretory IgА levels in tears were decreased in these groups of workers, as compared with controls. Concentrations of both immunoglobulins in tear samples depended on I105V and А114V glutathione-S-transferase P1 gene polymorphisms. I105V polymorphism correlated with lower concentrations of tear IgЕ in steelworkers with ocular dystrophic diseases and healthy metallurgists. А114V polymorphism is connected with decreased quantities of tear IgЕ in steelworkers with ocular dystrophic diseases, as well as with the lower amounts of secretory IgА in healthy workers and administrative staff. Hence, polymorphic loci I105V and А114V of glutathione-S-transferase P1 gene may exert a modulatory effect upon biosynthesis of both Ig types. (Med. Immunol., 2011, vol. 13, N 6, pp 609-616) |
format |
article |
author |
N. V. Mal’tseva O. F. Lykova M. A. Mel’nichenko S. V. Arkhipova A. L. Onishchenko |
author_facet |
N. V. Mal’tseva O. F. Lykova M. A. Mel’nichenko S. V. Arkhipova A. L. Onishchenko |
author_sort |
N. V. Mal’tseva |
title |
HE DEPENDENCE OF IMMUNOGLOBULIN IGA AND IGE TEAR LEVELS FROM GLUTATHIONES-TRANSFERASE P1 GENE POLYMORPHISMS IN STEELWORKERS WITH OPHTHALMOPATHY |
title_short |
HE DEPENDENCE OF IMMUNOGLOBULIN IGA AND IGE TEAR LEVELS FROM GLUTATHIONES-TRANSFERASE P1 GENE POLYMORPHISMS IN STEELWORKERS WITH OPHTHALMOPATHY |
title_full |
HE DEPENDENCE OF IMMUNOGLOBULIN IGA AND IGE TEAR LEVELS FROM GLUTATHIONES-TRANSFERASE P1 GENE POLYMORPHISMS IN STEELWORKERS WITH OPHTHALMOPATHY |
title_fullStr |
HE DEPENDENCE OF IMMUNOGLOBULIN IGA AND IGE TEAR LEVELS FROM GLUTATHIONES-TRANSFERASE P1 GENE POLYMORPHISMS IN STEELWORKERS WITH OPHTHALMOPATHY |
title_full_unstemmed |
HE DEPENDENCE OF IMMUNOGLOBULIN IGA AND IGE TEAR LEVELS FROM GLUTATHIONES-TRANSFERASE P1 GENE POLYMORPHISMS IN STEELWORKERS WITH OPHTHALMOPATHY |
title_sort |
he dependence of immunoglobulin iga and ige tear levels from glutathiones-transferase p1 gene polymorphisms in steelworkers with ophthalmopathy |
publisher |
SPb RAACI |
publishDate |
2014 |
url |
https://doaj.org/article/7b7853b3942445ad80b249bbf56761f5 |
work_keys_str_mv |
AT nvmaltseva hedependenceofimmunoglobulinigaandigetearlevelsfromglutathionestransferasep1genepolymorphismsinsteelworkerswithophthalmopathy AT oflykova hedependenceofimmunoglobulinigaandigetearlevelsfromglutathionestransferasep1genepolymorphismsinsteelworkerswithophthalmopathy AT mamelnichenko hedependenceofimmunoglobulinigaandigetearlevelsfromglutathionestransferasep1genepolymorphismsinsteelworkerswithophthalmopathy AT svarkhipova hedependenceofimmunoglobulinigaandigetearlevelsfromglutathionestransferasep1genepolymorphismsinsteelworkerswithophthalmopathy AT alonishchenko hedependenceofimmunoglobulinigaandigetearlevelsfromglutathionestransferasep1genepolymorphismsinsteelworkerswithophthalmopathy |
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