Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion

The secretory pathway is used in the production of most biopharmaceuticals, but the associated biosynthetic costs are little understood. Here, the authors integrate the core secretory pathway into genome-scale metabolic models of human, mouse, and CHO cells, enabling in silico analysis.

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Autores principales:	Jahir M. Gutierrez, Amir Feizi, Shangzhong Li, Thomas B. Kallehauge, Hooman Hefzi, Lise M. Grav, Daniel Ley, Deniz Baycin Hizal, Michael J. Betenbaugh, Bjorn Voldborg, Helene Faustrup Kildegaard, Gyun Min Lee, Bernhard O. Palsson, Jens Nielsen, Nathan E. Lewis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7b7b5cdd06f3404dbb201e1d925f5e77
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spelling	oai:doaj.org-article:7b7b5cdd06f3404dbb201e1d925f5e772021-12-02T17:32:42ZGenome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion10.1038/s41467-019-13867-y2041-1723https://doaj.org/article/7b7b5cdd06f3404dbb201e1d925f5e772020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13867-yhttps://doaj.org/toc/2041-1723The secretory pathway is used in the production of most biopharmaceuticals, but the associated biosynthetic costs are little understood. Here, the authors integrate the core secretory pathway into genome-scale metabolic models of human, mouse, and CHO cells, enabling in silico analysis.Jahir M. GutierrezAmir FeiziShangzhong LiThomas B. KallehaugeHooman HefziLise M. GravDaniel LeyDeniz Baycin HizalMichael J. BetenbaughBjorn VoldborgHelene Faustrup KildegaardGyun Min LeeBernhard O. PalssonJens NielsenNathan E. LewisNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jahir M. Gutierrez Amir Feizi Shangzhong Li Thomas B. Kallehauge Hooman Hefzi Lise M. Grav Daniel Ley Deniz Baycin Hizal Michael J. Betenbaugh Bjorn Voldborg Helene Faustrup Kildegaard Gyun Min Lee Bernhard O. Palsson Jens Nielsen Nathan E. Lewis Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion
description	The secretory pathway is used in the production of most biopharmaceuticals, but the associated biosynthetic costs are little understood. Here, the authors integrate the core secretory pathway into genome-scale metabolic models of human, mouse, and CHO cells, enabling in silico analysis.
format	article
author	Jahir M. Gutierrez Amir Feizi Shangzhong Li Thomas B. Kallehauge Hooman Hefzi Lise M. Grav Daniel Ley Deniz Baycin Hizal Michael J. Betenbaugh Bjorn Voldborg Helene Faustrup Kildegaard Gyun Min Lee Bernhard O. Palsson Jens Nielsen Nathan E. Lewis
author_facet	Jahir M. Gutierrez Amir Feizi Shangzhong Li Thomas B. Kallehauge Hooman Hefzi Lise M. Grav Daniel Ley Deniz Baycin Hizal Michael J. Betenbaugh Bjorn Voldborg Helene Faustrup Kildegaard Gyun Min Lee Bernhard O. Palsson Jens Nielsen Nathan E. Lewis
author_sort	Jahir M. Gutierrez
title	Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion
title_short	Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion
title_full	Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion
title_fullStr	Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion
title_full_unstemmed	Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion
title_sort	genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/7b7b5cdd06f3404dbb201e1d925f5e77
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Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion

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