Single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer

Transposon based screens carried out in mice can identify genes critical for tumourigensis. Here, the authors describe transposon screens in mouse models of breast cancer and highlight a large group of tumour suppressors that could underlie selection for common chromosome arm losses in cancer.

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Autores principales:	Nathan F. Schachter, Jessica R. Adams, Patryk Skowron, Katelyn. J. Kozma, Christian A. Lee, Nandini Raghuram, Joanna Yang, Amanda J. Loch, Wei Wang, Aaron Kucharczuk, Katherine L. Wright, Rita M. Quintana, Yeji An, Daniel Dotzko, Jennifer L. Gorman, Daria Wojtal, Juhi S. Shah, Paul Leon-Gomez, Giovanna Pellecchia, Adam J. Dupuy, Charles M. Perou, Ittai Ben-Porath, Rotem Karni, Eldad Zacksenhaus, Jim R. Woodgett, Susan J. Done, Livia Garzia, A. Sorana Morrissy, Jüri Reimand, Michael D. Taylor, Sean E. Egan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7b80ad2dd67744ecb57557946c051bff
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spelling	oai:doaj.org-article:7b80ad2dd67744ecb57557946c051bff2021-12-02T15:26:52ZSingle allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer10.1038/s41467-021-25467-w2041-1723https://doaj.org/article/7b80ad2dd67744ecb57557946c051bff2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25467-whttps://doaj.org/toc/2041-1723Transposon based screens carried out in mice can identify genes critical for tumourigensis. Here, the authors describe transposon screens in mouse models of breast cancer and highlight a large group of tumour suppressors that could underlie selection for common chromosome arm losses in cancer.Nathan F. SchachterJessica R. AdamsPatryk SkowronKatelyn. J. KozmaChristian A. LeeNandini RaghuramJoanna YangAmanda J. LochWei WangAaron KucharczukKatherine L. WrightRita M. QuintanaYeji AnDaniel DotzkoJennifer L. GormanDaria WojtalJuhi S. ShahPaul Leon-GomezGiovanna PellecchiaAdam J. DupuyCharles M. PerouIttai Ben-PorathRotem KarniEldad ZacksenhausJim R. WoodgettSusan J. DoneLivia GarziaA. Sorana MorrissyJüri ReimandMichael D. TaylorSean E. EganNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nathan F. Schachter Jessica R. Adams Patryk Skowron Katelyn. J. Kozma Christian A. Lee Nandini Raghuram Joanna Yang Amanda J. Loch Wei Wang Aaron Kucharczuk Katherine L. Wright Rita M. Quintana Yeji An Daniel Dotzko Jennifer L. Gorman Daria Wojtal Juhi S. Shah Paul Leon-Gomez Giovanna Pellecchia Adam J. Dupuy Charles M. Perou Ittai Ben-Porath Rotem Karni Eldad Zacksenhaus Jim R. Woodgett Susan J. Done Livia Garzia A. Sorana Morrissy Jüri Reimand Michael D. Taylor Sean E. Egan Single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer
description	Transposon based screens carried out in mice can identify genes critical for tumourigensis. Here, the authors describe transposon screens in mouse models of breast cancer and highlight a large group of tumour suppressors that could underlie selection for common chromosome arm losses in cancer.
format	article
author	Nathan F. Schachter Jessica R. Adams Patryk Skowron Katelyn. J. Kozma Christian A. Lee Nandini Raghuram Joanna Yang Amanda J. Loch Wei Wang Aaron Kucharczuk Katherine L. Wright Rita M. Quintana Yeji An Daniel Dotzko Jennifer L. Gorman Daria Wojtal Juhi S. Shah Paul Leon-Gomez Giovanna Pellecchia Adam J. Dupuy Charles M. Perou Ittai Ben-Porath Rotem Karni Eldad Zacksenhaus Jim R. Woodgett Susan J. Done Livia Garzia A. Sorana Morrissy Jüri Reimand Michael D. Taylor Sean E. Egan
author_facet	Nathan F. Schachter Jessica R. Adams Patryk Skowron Katelyn. J. Kozma Christian A. Lee Nandini Raghuram Joanna Yang Amanda J. Loch Wei Wang Aaron Kucharczuk Katherine L. Wright Rita M. Quintana Yeji An Daniel Dotzko Jennifer L. Gorman Daria Wojtal Juhi S. Shah Paul Leon-Gomez Giovanna Pellecchia Adam J. Dupuy Charles M. Perou Ittai Ben-Porath Rotem Karni Eldad Zacksenhaus Jim R. Woodgett Susan J. Done Livia Garzia A. Sorana Morrissy Jüri Reimand Michael D. Taylor Sean E. Egan
author_sort	Nathan F. Schachter
title	Single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer
title_short	Single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer
title_full	Single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer
title_fullStr	Single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer
title_full_unstemmed	Single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer
title_sort	single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7b80ad2dd67744ecb57557946c051bff
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Single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer

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