Photoactivable Ruthenium-Based Coordination Polymer Nanoparticles for Light-Induced Chemotherapy

Green light photoactive Ru-based coordination polymer nanoparticles (CPNs), with chemical formula [[Ru(biqbpy)]1.5(bis)](PF6)3 (biqbpy = 6,6′-bis[N-(isoquinolyl)-1-amino]-2,2′-bipyridine; bis = bis(imidazol-1-yl)-hexane), were obta...

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Autores principales:	Junda Zhang, Vadde Ramu, Xue-Quan Zhou, Carolina Frias, Daniel Ruiz-Molina, Sylvestre Bonnet, Claudio Roscini, Fernando Novio
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	coordination polymer nanoparticles nanoparticles photoactivated chemotherapy prodrug drug delivery ruthenium-based drug Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/7b82580cdff3491f9bc9c04150bc3777
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spelling	oai:doaj.org-article:7b82580cdff3491f9bc9c04150bc37772021-11-25T18:32:22ZPhotoactivable Ruthenium-Based Coordination Polymer Nanoparticles for Light-Induced Chemotherapy10.3390/nano111130892079-4991https://doaj.org/article/7b82580cdff3491f9bc9c04150bc37772021-11-01T00:00:00Zhttps://www.mdpi.com/2079-4991/11/11/3089https://doaj.org/toc/2079-4991Green light photoactive Ru-based coordination polymer nanoparticles (CPNs), with chemical formula [[Ru(biqbpy)]<sub>1.5</sub>(bis)](PF<sub>6</sub>)<sub>3</sub> (biqbpy = 6,6′-bis[N-(isoquinolyl)-1-amino]-2,2′-bipyridine; bis = bis(imidazol-1-yl)-hexane), were obtained through polymerization of the trans-[Ru(biqbpy)(dmso)Cl]Cl complex (Complex <b>1</b>) and bis bridging ligands. The as-synthesized CPNs (50 ± 12 nm diameter) showed high colloidal and chemical stability in physiological solutions. The axial bis(imidazole) ligands coordinated to the ruthenium center were photosubstituted by water upon light irradiation in aqueous medium to generate the aqueous substituted and active ruthenium complexes. The UV-Vis spectral variations observed for the suspension upon irradiation corroborated the photoactivation of the CPNs, while High Performance Liquid Chromatography (HPLC) of irradiated particles in physiological media allowed for the first time precisely quantifying the amount of photoreleased complex from the polymeric material. In vitro studies with A431 and A549 cancer cell lines revealed an 11-fold increased uptake for the nanoparticles compared to the monomeric complex [Ru(biqbpy)(N-methylimidazole)<sub>2</sub>](PF<sub>6</sub>)<sub>2</sub> (Complex <b>2</b>). After irradiation (520 nm, 39.3 J/cm<sup>2</sup>), the CPNs yielded up to a two-fold increase in cytotoxicity compared to the same CPNs kept in the dark, indicating a selective effect by light irradiation. Meanwhile, the absence of <sup>1</sup>O<sub>2</sub> production from both nanostructured and monomeric prodrugs concluded that light-induced cell death is not caused by a photodynamic effect but rather by photoactivated chemotherapy.Junda ZhangVadde RamuXue-Quan ZhouCarolina FriasDaniel Ruiz-MolinaSylvestre BonnetClaudio RosciniFernando NovioMDPI AGarticlecoordination polymer nanoparticlesnanoparticlesphotoactivated chemotherapyprodrugdrug deliveryruthenium-based drugChemistryQD1-999ENNanomaterials, Vol 11, Iss 3089, p 3089 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	coordination polymer nanoparticles nanoparticles photoactivated chemotherapy prodrug drug delivery ruthenium-based drug Chemistry QD1-999
spellingShingle	coordination polymer nanoparticles nanoparticles photoactivated chemotherapy prodrug drug delivery ruthenium-based drug Chemistry QD1-999 Junda Zhang Vadde Ramu Xue-Quan Zhou Carolina Frias Daniel Ruiz-Molina Sylvestre Bonnet Claudio Roscini Fernando Novio Photoactivable Ruthenium-Based Coordination Polymer Nanoparticles for Light-Induced Chemotherapy
description	Green light photoactive Ru-based coordination polymer nanoparticles (CPNs), with chemical formula [[Ru(biqbpy)]<sub>1.5</sub>(bis)](PF<sub>6</sub>)<sub>3</sub> (biqbpy = 6,6′-bis[N-(isoquinolyl)-1-amino]-2,2′-bipyridine; bis = bis(imidazol-1-yl)-hexane), were obtained through polymerization of the trans-[Ru(biqbpy)(dmso)Cl]Cl complex (Complex <b>1</b>) and bis bridging ligands. The as-synthesized CPNs (50 ± 12 nm diameter) showed high colloidal and chemical stability in physiological solutions. The axial bis(imidazole) ligands coordinated to the ruthenium center were photosubstituted by water upon light irradiation in aqueous medium to generate the aqueous substituted and active ruthenium complexes. The UV-Vis spectral variations observed for the suspension upon irradiation corroborated the photoactivation of the CPNs, while High Performance Liquid Chromatography (HPLC) of irradiated particles in physiological media allowed for the first time precisely quantifying the amount of photoreleased complex from the polymeric material. In vitro studies with A431 and A549 cancer cell lines revealed an 11-fold increased uptake for the nanoparticles compared to the monomeric complex [Ru(biqbpy)(N-methylimidazole)<sub>2</sub>](PF<sub>6</sub>)<sub>2</sub> (Complex <b>2</b>). After irradiation (520 nm, 39.3 J/cm<sup>2</sup>), the CPNs yielded up to a two-fold increase in cytotoxicity compared to the same CPNs kept in the dark, indicating a selective effect by light irradiation. Meanwhile, the absence of <sup>1</sup>O<sub>2</sub> production from both nanostructured and monomeric prodrugs concluded that light-induced cell death is not caused by a photodynamic effect but rather by photoactivated chemotherapy.
format	article
author	Junda Zhang Vadde Ramu Xue-Quan Zhou Carolina Frias Daniel Ruiz-Molina Sylvestre Bonnet Claudio Roscini Fernando Novio
author_facet	Junda Zhang Vadde Ramu Xue-Quan Zhou Carolina Frias Daniel Ruiz-Molina Sylvestre Bonnet Claudio Roscini Fernando Novio
author_sort	Junda Zhang
title	Photoactivable Ruthenium-Based Coordination Polymer Nanoparticles for Light-Induced Chemotherapy
title_short	Photoactivable Ruthenium-Based Coordination Polymer Nanoparticles for Light-Induced Chemotherapy
title_full	Photoactivable Ruthenium-Based Coordination Polymer Nanoparticles for Light-Induced Chemotherapy
title_fullStr	Photoactivable Ruthenium-Based Coordination Polymer Nanoparticles for Light-Induced Chemotherapy
title_full_unstemmed	Photoactivable Ruthenium-Based Coordination Polymer Nanoparticles for Light-Induced Chemotherapy
title_sort	photoactivable ruthenium-based coordination polymer nanoparticles for light-induced chemotherapy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7b82580cdff3491f9bc9c04150bc3777
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_version_	1718411026458738688

Photoactivable Ruthenium-Based Coordination Polymer Nanoparticles for Light-Induced Chemotherapy

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